Psychological therapies versus antidepressant medication, alone and in combination for depression in children and adolescents

Abstract

Analysis 4.3. Comparison 4 Combination therapy versus psychological therapy plus placebo, Outcome 3 Remission by cutoff (post-intervention).

The development of an RDoC-based treatment program for adolescent depression: “Training for Awareness, Resilience, and Action” (TARA)

“…Follow-up studies of both pharmacotherapy and psychotherapy randomized controlled trials (RCTs) show that 25–50% of the depressed adolescents relapse within 6 months to 2 years post-treatment (March and Vitiello, 2009). A recent Cochrane meta-analysis concluded that there is very limited evidence demonstrating the relative effectiveness of antidepressant medication, psychological interventions, and a combination of these interventions in depressed youth (Cox et al, 2012). However, despite the fact that pharmacological treatments of mild to moderate adolescent MDD have not shown significant treatment effects and may introduce both short- and potential long-term negative side effects (Hetrick et al, 2007; Adegbite-Adeniyi et al, 2012), 14.1% of adolescents with primary mood disorders are treated with antidepressant medication in the U.S. (Merikangas et al, 2013).…”