Psychological test performance and sedation thresholds of elderly dements, depressives and depressives with incipient brain change

Davies, Gareth T.; Hamilton, S.H.; Hendrickson, D. E.; Levy, Raymond; Post, Felix

doi:10.1017/s003329170000667x

Cited by 22 publications

(16 citation statements)

References 8 publications

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“…Alternatively, it could be a reflection of some as yet undefined ageing process within the nervous system which renders those with a constitutional predisposition to affective disorder more liable to manifest it clinically. The latter explanation has been advanced previously from this centre to explain abnormalities in barbiturate threshold (Davies et al, 1978), auditory evoked response (Hendrickson et al, 1979), and CT abnormalities (Jacoby and Levy, 1980;Jacoby et al, 1981) in depressed patients.…”

Section: Ctscansmentioning

confidence: 78%

Mania in old age: A First Prospective Study

Broadhead

Jacoby

1990

Int J Geriat Psychiatry

131

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SUMMARYIn a first prospective study of manic illness in old age, 35 manic patients over the age of 60 were compared with 35 patients below the age of 40 on clinical and cognitive measures. CT scan comparisons were made between the elderly patients and age-matched healthy controls. Contrary to previously accepted teaching, the elderly were effectively clinically indistinguishable from the younger patients, except that the latter experienced more severe illnesses. CT and cognitive results, however, in the elderly group showed evidence of changes which support the view that cerebral organic factors play an important role in the genesis of affective disorder in old age.

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Section: Ctscansmentioning

confidence: 78%

Mania in old age: A First Prospective Study

Broadhead

Jacoby

1990

Int J Geriat Psychiatry

131

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“…Hemsi et al (1968) found alterations in the barbiturate threshold of elderly depressed patients, although the findings were not entirely confirmed in a later study (Davies et al, 1978). Hendrickson et al (1979) demonstrated a delay in the auditory evoked response (AER) in a similar group of patients.…”

mentioning

confidence: 96%

Quantitative Computed Tomography in Elderly Depressed Patients

et al. 1983

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SummaryAn index of brain tissue density was obtained from the CT scans of 37 elderly depressed patients by measuring Hounsfield Units (HU) in 12 predefined brain areas. Comparisons were made with 23 patients suffering from senile dementia and 36 healthy controls. As a group the depressed patients resembled the dements more than the controls, although analysis of variance indicated differences between all three groups, controls showing the highest HU values and dements the lowest. In the depressed patients ventricular dilatation, which had already been shown to predict increased mortality, was also associated with lower HU levels. The significance of these and other findings is discussed.

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“…O grupo estudado é semelhante aos encontrados na literatura, o que sugere que embora pacientes idosos com depressão apresentem perfis clínicos essencialmente semelhantes aos dos pacientes jovens 17 , eles parecem ter mudanças psicomotoras mais severas e falhas cognitivas demonstráveis 1,18 . Quanto aos hipersinais subcorticais, não foram encontradas diferenças estatisticamente significativas entre os idosos deprimidos e os idosos sadios em região periventricular (HPV), na substância branca profunda (HSBP) e nos núcleos profundos de substância cinzenta (HNPSC) (Tabela 2).…”

Section: Métodounclassified

Hipersinais subcorticais no exame de ressonância magnética: comparação entre idosos deprimidos e idosos normais

Novaretti

Marcolin

Meira

et al. 2001

Arq. Neuro-Psiquiatr.

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RESUMO É relatado em alguns estudos que idosos deprimidos apresentam maior frequência de hipersinais ao exame de ressonância magnética do que controles normais. No entanto os indivíduos estudados tinham fatores de risco para doenças cerebrovasculares. Este estudo analisou pacientes com história de depressão maior e indivíduos controles compatíveis, excluindo-se fatores de risco cerebrovasculares, com o objetivo de determinar se indivíduos deprimidos apresentam maior frequência de hipersinais em substância branca e outras lesões. Avaliamos a prevalência e a severidade dos hipersinais à ressonância magnética de encéfalo em 30 pacientes idosos deprimidos e 20 controles pareados para a idade. Hipersinais de substância branca profunda, hipersinais periventriculares e hipersinais em substância cinzenta subcortical foram classificados em escala padrão 0-3, por dois radiologistas que desconheciam o diagnóstico clínico. Não foram encontradas diferenças significativas entre os grupos para hipersinais subcorticais. Estes achados sugerem que os fatores de risco cerebrovasculares provavelmente medeiam a relação entre depressão e hipersinais, encontrada em estudos anteriores.PALAVRAS-CHAVE: demência vascular, ressonância magnética nuclear, depressão, idoso. Subcortical hyperintensities on magnetic resonance imaging: a comparison of normal and depressed elderly subjectsABSTRACT -Previous studies reported that depressed subjects had more signal hyperintensities on magnetic resonance imaging scans than control subjects, but the subjects had cerebrovascular disease risk factors. This study used subjects with a history of major depression and matched comparison subjects, screened to exclude cerebrovascular risk factors, to determine whether depressed subjects had more white matter hyperintensities and other lesions. We evaluated the prevalence and severity of MRI signal hyperintensities in 30 elderly depressed patients and 20 controls matched for age. Deep matter hyperintensities, periventricular hyperintensities and subcortical gray hyperintensities were rated on a standard 0-3 scale by two radiologists blind to clinical diagnosis. No significant differences were found between groups for the presence of subcortical gray matter, deep white matter and periventricular hyperintensities. These findings suggest that cerebrovascular disease risk factors most likely mediated the relationship between depression and hyperintensities in previous studies.KEY WORDS: vascular dementia, magnetic resonance imaging, depression, elderly. Existem poucas características clínicas que distinguem os idosos que apresentam depressão iniciada precocemente daqueles com depressão de início tardio 1-4 indicando que, se houver fatores de risco associados à idade, eles não podem ser identificados apenas por estas características. O risco familiar para depressão declina com o envelhecimento e os transtornos de início tardio podem, mais frequentemente, ser consequência de doenças cuja incidência aumenta com a idade como as doenças vasculares e neurodegenerativas...

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Psychological test performance and sedation thresholds of elderly dements, depressives and depressives with incipient brain change

Cited by 22 publications

References 8 publications

Mania in old age: A First Prospective Study

Mania in old age: A First Prospective Study

Quantitative Computed Tomography in Elderly Depressed Patients

Hipersinais subcorticais no exame de ressonância magnética: comparação entre idosos deprimidos e idosos normais

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