Psychological Symptoms in Primary Immunodeficiencies: a Common Comorbidity?

Manusama, Olivia; Beveren, Nico J.M. van; Hagen, P. Martin van; Drexhage, Hemmo A.; Dalm, Virgil A. S. H.

doi:10.1007/s10875-022-01207-7

Cited by 7 publications

(2 citation statements)

References 5 publications

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“…However, despite the evident improvement in the overall survival rate of the IEI population due to these treatment modalities and interventions, most patients with IEI still face challenges such as recurrent infections and frequent hospitalizations attributed to the chronic characteristics of IEI, treatment side effects, and the complexity of care management. This limits their normal physical and social activities ( 16 , 17 ), making them more prone to anxiety ( 18 ), fatigue ( 19 ), depression ( 20 ), and increases their risk of cardiovascular diseases (CVD), malignancies, sleep disorders, and psychiatric conditions ( 21 – 23 ), severely impacting their physical and psychological health, and reducing their QoL and well-being. Therefore, it is imperative to extend the current clinical survival rate/disease parameter assessments to evaluate the overall health status of patients with IEI, aiding researchers, clinicians, and caregivers in better understanding the patient’s health condition.…”

Section: Introductionmentioning

confidence: 99%

Health-related quality of life in patients with inborn errors of immunity: a bibliometric analysis

Xiao,

Huang,

Zang

et al. 2024

Front. Immunol.

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BackgroundInborn Errors of Immunity (IEI) are characterized by a heightened susceptibility to infections, allergies, and various other health complications. Health-Related Quality of Life (HRQOL) in patients with IEI is a critical area of research that demands attention due to the impact of IEI on patients’ lives. This study utilized bibliometric methods, aiming to comprehensively explore the research content and hotspots in the field of HRQOL in patients with IEI.MethodsThis bibliometric analysis utilized data from the Science Citation Index Expanded (SCIE) and Social Sciences Citation Index (SSCI) within the Web of Science core datasets up to January 1, 2024. The study focused on literature that addressed HRQOL in IEI patients, involving a total of 1,807 authors and 309 articles published across 112 journals. The analysis included publication volume and growth trends, country and institutional contributions, authorship, and journal analysis.ResultsThe research found that despite the importance of HRQOL in IEI, the volume of publications in this field remains consistently low, with no significant increase in trend. The USA leads in publication and citation volumes, reflecting a geographical imbalance in research contributions. Key journals in this field include the Journal of Clinical Immunology, Frontiers in Immunology, and the Journal of Allergy and Clinical Immunology. The study highlights that while treatments like hematopoietic stem cell transplants and gene therapy have improved patient IEI survival rates, they still often come with significant side effects impacting HRQOL. The analysis underlines the need for comprehensive HRQOL assessments in IEI, considering the physical and psychological impacts of treatments.ConclusionsThis study represents a bibliometric analysis focusing on HRQOL in patients with. It underscores the need for more extensive and systematic research in this area, emphasizing the importance of a multidisciplinary approach. Despite advancements in medical treatments for IEI, there is a crucial need to focus on HRQOL to enhance patient satisfaction and overall well-being. The findings advocate for more personalized treatment plans and a better understanding of the psychosocial needs of patients with IEI to improve their quality of life.

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Section: Introductionmentioning

confidence: 99%

Health-related quality of life in patients with inborn errors of immunity: a bibliometric analysis

Xiao,

Huang,

Zang

et al. 2024

Front. Immunol.

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“…Previously, patients with IEI were mainly assessed for the prevalence of depression. However, some studies revealed that anxiety is potentially more prevalent than depression among patients with IEI ( 20 ), and it is often overlooked in clinical practice. In our previous study ( 3 ), which included a part of the current study (n=92), anxiety symptoms were frequent.…”

Section: Introductionmentioning

confidence: 99%

Anxiety in Polish adult patients with inborn errors of immunity: a cross-sectional study

Grochowalska,

Ziętkiewicz,

Nowicka-Sauer

et al. 2024

Front. Psychiatry

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BackgroundPatients with inborn errors of immunity (IEI) experience recurrent infections, autoimmunity, and malignancies. Owing to repeated medical procedures, the need for constant treatment and surveillance, and the unpredictable course of the disease, patients with IEI are prone to develop mental health disorders, including anxiety. In this study, we aimed to assess the prevalence and level of anxiety symptoms in adult Polish patients with IEI and explore the determinants of anxiety in this group of patients.MethodsData from 105 Polish patients with IEI were collected via the hospital anxiety and depression scale (HADS), brief illness perception questionnaire (B-IPQ), illness cognition questionnaire (ICQ), Pittsburgh sleep quality index (PSQI), and a questionnaire on general health and demographic data. For statistical analyses of data, the normality of distribution of quantitative data was assessed, and internal consistency of tests was investigated using Cronbach’s alpha coefficient; moreover, we performed the analysis of correlations and between-group differences, and path analysis to explore causal relationships. Significance was considered at p < 0.050.ResultsThirty-eight (36.2%) patients had anxiety symptoms (HADS-A ≥ 8); 14 (13.3%) patients had severe anxiety (score ≥ 11), and 24 (22.9%) had moderate anxiety (score of 8–10). Patients with poor sleep quality, higher pain frequency, younger age, and no fixed income had higher anxiety scores than others. Emotional and cognitive representations of illness were positively correlated with anxiety levels. Intense anxiety was related to more negative illness perception, higher helplessness, lower illness acceptance, and lower perceived benefits.DiscussionAnxiety is common in patients with IEI. However, results indicate that it is not related to a more severe course of IEI or several comorbidities, whereas, pain frequency and poor sleep quality were identified to be important clinical factors for anxiety. Because anxiety was related to negative illness perception, psychological therapy may apply to this group of patients.

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Impact of COVID-19 Pandemic on Clinical Care of Patients and Psychosocial Health of Affected Families with Chronic Granulomatous Disease: an Observational Study from North India

et al. 2023

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Day-to-day clinical management of patients with inborn errors of immunity, including chronic granulomatous disease (CGD), has been affected by the coronavirus disease-2019 (COVID-19) pandemic. There is a dearth of information on impact of this pandemic on clinical care of children with CGD and psychological profile of the caretakers. Among the 101 patients with CGD followed up in our center, 5 children developed infection/complications associated with COVID-19. Four of these children had a mild clinical course, while 1 child developed features of multisystem inflammatory syndrome in children (MISC) requiring intravenous glucocorticoids. Parents and caretakers of CGD patients ( n = 21) and 21 healthy adults with similar ages and genders were also evaluated on the following scales and questionnaires: COVID-19 Fear Scale (FCV 19S), Impact of Event Scale (IES-R), Depression, Anxiety, and Stress Scale (DASS 21), Preventive COVID-19 Behavior Scale (PCV 19BS), and a “COVID-19 Psychological wellbeing questionnaire.” Median age of the parents/caregivers was 41.76 years (range: 28–60 years). Male:female ratio was 2:1. In the study group, 71.4% had higher IES scores compared to 14.3% in controls. The caregivers had a high prevalence of stress, anxiety, avoidance behavior, and depression compared to controls ( p < 0.001). Children with CGD have had predominantly mild infection with COVID-19; however, caregivers/parents of these children were at risk of developing psychological distress. The COVID-19 pandemic has brought to light the importance of patients’ and caretakers’ mental health which needs periodic assessment and appropriate interventions. Supplementary Information The online version contains supplementary material available at 10.1007/s10875-023-01524-5.

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Psychological Symptoms in Primary Immunodeficiencies: a Common Comorbidity?

Cited by 7 publications

References 5 publications

Health-related quality of life in patients with inborn errors of immunity: a bibliometric analysis

Health-related quality of life in patients with inborn errors of immunity: a bibliometric analysis

Anxiety in Polish adult patients with inborn errors of immunity: a cross-sectional study

Impact of COVID-19 Pandemic on Clinical Care of Patients and Psychosocial Health of Affected Families with Chronic Granulomatous Disease: an Observational Study from North India

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