Psychological stress increases dopamine turnover selectively in mesoprefrontal dopamine neurons of rats: reversal by diazepam

Kaneyuki, Hiroshi; Yokoo, Hideyasu; Tsuda, Atsushi; Yoshida, Masami; Mizuki, Yasushi; Yamada, Masakazu; Tanaka, Masatoshi

doi:10.1016/0006-8993(91)90129-j

Cited by 131 publications

(48 citation statements)

References 31 publications

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“…Importantly, however, a role for DA has not been ruled out. For example, acute stress rapidly activates DA neurons in the VTA [144] and increases DA release in the NAc [143,260,289] and mPFC [277,312]. Stress-induced elevation of NAc DA correlates temporally with reinstatement of heroin seeking [259].…”

Section: Summary Of Effects Of Sb-277011-a On Addictive Drug Actionmentioning

confidence: 99%

The role of central dopamine D3 receptors in drug addiction: a review of pharmacological evidence

Heidbreder

Gardner

et al. 2005

Brain Research Reviews

303

249

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The cDNA for the dopamine D 3 receptor was isolated and characterized in 1990. Subsequent studies have indicated that D 3 receptors, as well as D 3 receptor mRNA, are primarily localized in limbic regions in mammals. This finding led to the postulate that D 3 receptors may be involved in drug dependence and addiction. However, this hypothesis has been difficult to test due to the lack of compounds with high selectivity for central D 3 receptors. The interpretation of results from studies using mixed D 2 /D 3 agonists and/or antagonists is problematic because these agents have low selectivity for D 3 over D 2 receptors and it is likely that their actions are primarily related to D 2 receptor antagonism and possibly interaction with other neurotransmitter receptors. Currently, with the synthesis and characterization of new highly selective D 3 receptor antagonists such as SB-277011-A this difficulty has been surmounted. The purpose of the present article is to review, for the first time, the effects of various putative D 3 receptor selective compounds in animal models of drug dependence and addiction. The results obtained with highly selective D 3 receptor antagonists such as SB-277011-A, SB-414796, and NGB-2904 indicate that central D 3 receptors may play an important role in drug-induced reward, drug-taking, and cue-, drug-, and stressinduced reinstatement of drug-seeking behavior. Provided these results can be extrapolated to human drug addicts, they suggest that selective DA D 3 receptor antagonists may prove effective as potential pharmacotherapeutic agents to manage drug dependence and addiction.

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Section: Summary Of Effects Of Sb-277011-a On Addictive Drug Actionmentioning

confidence: 99%

The role of central dopamine D3 receptors in drug addiction: a review of pharmacological evidence

Heidbreder

Gardner

et al. 2005

Brain Research Reviews

303

249

View full text Add to dashboard Cite

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“…42 The response of the dopaminergic system to stress is neither homogenous nor generalized, and numerous results suggest that mesoprefrontal cortex dopaminergic projections are selectively activated by sudden changes in environmental conditions, whether expected or not. 43 The fine tuning of dopamine extracellular concentration in the medial prefrontal cortex seems to be essential for the decision-taking protocols of the medial prefrontal cortex in the rat and the monkey. 44 This supports the idea of a critical range of dopamine turnover for optimal prefrontal cortical cognitive functioning, with reduced or excessive dopamine turnover leading to cognitive impairment.…”

Section: Stressmentioning

confidence: 99%

Is there an evolutionary mismatch between the normal physiology of the human dopaminergic system and current environmental conditions in industrialized countries?

Pani

2000

Mol Psychiatry

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A large body of evidence has recently defined a field theory known as 'evolutionary mismatch', which derives its attributes largely from the fact that current environmental conditions are completely different from those in which the human central nervous system evolved. Current views on the evolutionary mismatch theory lack, however, any attempts to define which brain areas or neuronal circuits should be mostly involved in coding such misevolved traits and to what extent our neurobiological knowledge can be applied to the topographical localization of a specific psychopathology. In this respect the mesocorticolimbic dopaminergic circuits have long been misconceptualized as simple reward or reinforcement systems. Instead, they motivate and coordinate the functions of the higher brain areas that mediate planning and foresight and direct finalized movement in both animals and humans. These systems make animals intensely interested in exploring the world around them, but by the same means they also make them susceptible to the environmental stimuli that have been sought and consumed. It is has been speculated that the cortical dopamine targets that developed most recently in phylogeny are of particular functional value, and that the mesocorticolimbic dopaminergic system is involved in more complex integrative functions than previously assumed. In the present paper I will argue that some mental disorders may have their deep roots in the evolutionary mismatch between the normal physiology of the mesocorticolimbic dopaminergic system and the current environmental conditions in affluent societies. Molecular Psychiatry (2000) 5, 467-475.

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“…[5][6][7] In this, the response of the dopaminergic system is neither homogenous nor generalized, and numerous results suggest that mesoprefrontal cortex (MFC) DA neurons are selectively activated by sudden changes in environmental conditions whether expected or not, and that the activation of the A10 cell body site precedes that of the terminal fields. 8 Interestingly, the nucleus accumbens (NAc) DA reaction to internal or external perturbations is dampened by the concurrent activation of MFC DA neurons; an action mediated, at least in part, by D1 receptors in the MFC. 9 When 6-OHDA lesions are produced in the prefrontal cortex, mild footshock results in a significant increase in the concentration of DOPAC in the NAc.…”

Section: Introductionmentioning

confidence: 99%

The role of stress in the pathophysiology of the dopaminergic system

2000

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In this review, we will examine the most recent preclinical evidence in support of the fact that both acute and chronic stress may have a detrimental impact on the normal function of the dopaminergic system. In recent decades, the term stress has changed its meaning from that of a 'non-specific body response' to a 'monitoring system of internal and external cues'; that is a modality of reaction of the mammalian central nervous system (CNS) which is critical to the adaptation of the organism to its environment. Compelling results have demonstrated that the dopaminergic system is important not only for hedonic impact or reward learning but also, in a broader sense, for reactivity to perturbation in environmental conditions, for selective information processing, and for general emotional responses, which are essential functions in the ability (or failure) to cope with the external world. In this, stress directly influences several basic behaviors which are mediated by the dopaminergic system such as locomotor activity, sexual activity, appetite, and cross sensitization with drugs of abuse. Studies using rat lines which are genetically different in dopamine (DA) physiology, have shown that even small alterations in the birth procedure or early life stress events may contribute to the pathophysiology of psychiatric disorders-in particular those involving central DA dysfunctionand may cause depression or psychotic derangement in the offspring. Finally, the fact that the dopaminergic system after stress responds, preferentially, in the medial prefrontal cortex (MFC), is thought to serve, in humans, as a protection against positive psychotic symptoms, since the increased DA activity in the MFC suppresses limbic DA transmission. However, excessive MFC dopaminergic activity has a negative impact on the cognitive functions of primates, making them unable to select and process significant environmental stimuli. Thus it appears that a critical range of DA turnover is necessary for optimal cognitive functioning after stress, in the response of the CNS to ever-changing environmental demands. Molecular Psychiatry (2000) 5, 14-21.

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Psychological stress increases dopamine turnover selectively in mesoprefrontal dopamine neurons of rats: reversal by diazepam

Cited by 131 publications

References 31 publications

The role of central dopamine D3 receptors in drug addiction: a review of pharmacological evidence

The role of central dopamine D3 receptors in drug addiction: a review of pharmacological evidence

Is there an evolutionary mismatch between the normal physiology of the human dopaminergic system and current environmental conditions in industrialized countries?

The role of stress in the pathophysiology of the dopaminergic system

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