Psychological stress disturbs bone metabolism via miR-335-3p/Fos signaling in osteoclast
Jiayao Zhang,
Juan Li,
Jiehong Huang
et al.
Abstract:It has been well-validated that chronic psychological stress leads to bone loss, but the underlying mechanism remains unclarified. In this study, we established and analyzed the chronic unpredictable mild stress (CUMS) mice to investigate the miRNA-related pathogenic mechanism involved in psychological stress-induced osteoporosis. Our result found that these CUMS mice exhibited osteoporosis phenotype that mainly attributed to the abnormal activities of osteoclasts. Subsequently, miRNA sequencing and other anal… Show more
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