Psychological Sequelae and Alopecia Among Women with Cancer

McGarvey, Elizabeth L.; Baum, Lora D.; Pinkerton, Relana C.; Rogers, Laura M.

doi:10.1046/j.1523-5394.2001.96007.x

Cited by 181 publications

(109 citation statements)

References 41 publications

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“…Cancer can become visible as the disease progresses or treatment side effects become obvious (MacDonald and Anderson, 1984; Peters-Golden, 1982). Cancer survivors indicate a poor quality of life due to their appearance, particularly hair loss (McGarvey et al, 2001; Rosman, 2004), and individuals described as having a visible cancer in a context where stigmatization could be perceived as subtle were found to be least likely to receive help (Knapp-Oliver and Moyer, 2009). …”

Section: Disease/treatment Characteristicsmentioning

confidence: 99%

Identity threat and stigma in cancer patients

Knapp

Marziliano

Moyer

2014

Health Psychology Open

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Cancer stigma has undergone an important transformation in recent decades. In general, this disease no longer fits squarely into Goffman’s classic taxonomy of stigmatized conditions. This review will demonstrate that, with important adaptations, an identity-threat model of stigma can be used to organize cancer stigma research post-Goffman. This adapted model postulates that one’s personal attributions, responses to situational threat, and disease/treatment characteristics can be used to predict identity threat and well-being of individuals with cancer. Implications for further research and clinical practice are discussed.

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Section: Disease/treatment Characteristicsmentioning

confidence: 99%

Identity threat and stigma in cancer patients

Knapp

Marziliano

Moyer

2014

Health Psychology Open

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“…Hair loss is a common side effect (7–9). It brings psychosocial stress, compromises patients’ sense of personal identity and even jeopardizes the willingness for treatment (8,10). Prevention of such hair loss is still an unmet clinical need (7,8).…”

Section: Introductionmentioning

confidence: 99%

Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy

et al. 2017

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Genotoxicity-induced hair loss from chemotherapy and radiotherapy is often encountered in cancer treatment, and there is a lack of effective treatment. In growing hair follicles (HF), quiescent stem cells (SC) are maintained in the bulge region and hair bulbs at the base contain rapidly dividing, yet genotoxicity-sensitive transit-amplifying cells (TAC) that maintain hair growth. How genotoxicity-induced HF injury is repaired remains unclear. We report here that HF mobilize ectopic progenitors from distinct TAC compartments for regeneration in adaptation to the severity of dystrophy induced by ionizing radiation (IR). Specifically, after low-dose IR, keratin5+ basal hair bulb progenitors, rather than bulge SC, were quickly activated to replenish matrix cells and regenerated all concentric layers of HF, demonstrating their plasticity. After high-dose IR, when both matrix and hair bulb cells were depleted, the surviving outer root sheath cells rapidly acquired a SC-like state and fueled HF regeneration. Their progeny then homed back to SC niche and supported new cycles of HF growth. We also revealed that IR induced HF dystrophy and hair loss and suppressed WNT signaling in a p53- and dose-dependent manner. Augmenting WNT signaling attenuated the suppressive effect of p53 and enhanced ectopic progenitor proliferation after genotoxic injury, thereby preventing both IR- and cyclophosphamide-induced alopecia. Hence, targeted activation of TAC-derived progenitor cells, rather than quiescent bulge SC, for anagen HF repair can be a potential approach to prevent hair loss from chemotherapy and radiotherapy.

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“…Patients perceive hair loss as one of the most distressing side-effects of cancer treatment,[1234] and often report that they were insufficiently prepared for it. [5] CIA may have a negative impact on body image and quality of life.…”

Section: Introductionmentioning

confidence: 99%

Familiarity, opinions, experiences and knowledge about scalp cooling: a Dutch survey among breast cancer patients and oncological professionals

Peerbooms

Hurk

Breed

2015

Asia-Pacific Journal of Oncology Nursing

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Objective:Scalp cooling (SC) is applied to reduce chemotherapy-induced alopecia (CIA). The aim of this study was to investigate patients’ familiarity and opinions and oncological professionals’ attitude and knowledge about SC in the Netherlands.Methods:Ex breast cancer patients, nurses and medical oncologists (MDs) from SC and non-SC hospitals filled out questionnaires.Results:The majority of MDs and nurses were satisfied with the results of SC, as were SC patients. Over 33% of MDs and nurses perceived their knowledge level insufficient to inform patients about effectiveness, which was over 43% for information about safety. MDs main reason to not apply SC was doubt about effectiveness and safety. Nurses generally offered SC to a minority of eligible patients. Patients were frequently unfamiliar with SC before diagnosis. Seventy percent of SC patients with insufficient results (20/52) reported to mind it very much. With expected success rates of 35% and 50%, respectively, 36% and 54% of patients would use SC again.Conclusion:Room for improvement has been shown for both patients’ familiarity and oncological professionals’ knowledge about SC. Sharing knowledge about results, safety and patients’ experiences will improve patient counseling and SC availability. The results of this survey led to the development of a national standard on CIA and SC.

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Psychological Sequelae and Alopecia Among Women with Cancer

Cited by 181 publications

References 41 publications

Identity threat and stigma in cancer patients

Identity threat and stigma in cancer patients

Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy

Familiarity, opinions, experiences and knowledge about scalp cooling: a Dutch survey among breast cancer patients and oncological professionals

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