Psychological predictors of the antihypertensive effects of music-guided slow breathing

Background. Tai Chi is effective in preventing heart disease (CHD) risk, but the molecular mechanism remains unclear. Mitogen-activated protein kinase (MAPK) signaling plays a critical role in the pathogenesis of CHD and can be activated by miR-126. Tai Chi may exert its protective function through the miR-126-modulated MAPK pathway. Methods. The CHD patients after PCI were randomized into the CG group (CG) (n = 19, normal care) and Tai Chi group (TG) (Tai Chi intervention, n = 17). Epicardial adipose tissue volume (EATV) (one main adverse cardiovascular event of CHD), HR (heart rate), QoL (quality of life) scores, and balance performance were measured in the two groups. The body fat content, abdominal subcutaneous fat, and visceral fat were measured to reflect the improvement of adipose tissue dysfunction. The levels of miR-126 and MAPK-associated molecules were measured in peripheral blood leukocytes. Meanwhile, the effects of miR-126 silence and mimic on MAPK-associated molecules were also explored in cardiac cell H9C2. Results. After the 3-month intervention, Tai Chi reduced EATV and HR and increased QoL scores and balance performance, respectively (P<0.05). The fat percentage, body fat mass, and BMI were also significantly reduced after Tai Chi intervention (P<0.05). The levels of miR-126, MAPK, JNK, and ERK in the TG group were lower than those in the CG group (P<0.05). The miR-126 levels had a strong relationship with the values of EATV, HR, and QoL scores (P<0.05). miR-126 silence or mimic inactivated or activated MAPK-associated molecules in the cardiac cell lines. Conclusions. Tai Chi improved CHD risk by inactivating the MAPK/ERK pathway via serum miR-126.

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“…e results of this study showed that SBP and DBP decreased in the TG group, which is consistent with the results of Modesti [50].…”

Section: Discussionsupporting

confidence: 91%

Tai Chi Improves Coronary Heart Disease Risk by Inactivating MAPK/ERK Pathway through Serum miR‐126

Zhang

Wang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…The effects detected are similar in magnitude to those observed with other methods capable of inducing a relaxation response, such as music-guided slow breathing [Grossman 2001;Modesti 2010].…”

Section: Discussionsupporting

confidence: 74%

Multidisciplinary Psychosomatic Assessment for UX Design Evaluation

Bonacchi

Ferrari²,

Camilleri³

et al. 2018

SDH

Self Cite

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“In the mirror of the Wonder of Luca Giordano” was a multi-sensorial experience created in the gallery frescoed by Luca Giordano in Palazzo Medici Riccardi, in Florence; the project involved different disciplines and researchers. The entire experience was subjected to an impact analysis, combining principally psycho-physiological, qualitative psychological and neuro-physiological aspects. In most of the visitors who participated in the study the experience evoked a sense of pleasure, enjoyment, relaxation, lightness, space-time suspension, involvement and immersiveness. In many of the visitors, the devices detected changes in heartbeat with a stastically significant decrease in blood pressure and heart rate, demontrating that the impact of artwork in a multi-sensorial experience and in an augmented perception environment is a psycho-somatic impact. Our experience suggests that projects such as "In the mirror of the Wonder of Luca Giordano" could be a very useful tool for cultivating emotional intelligence and could be developed in museums alongside the more classical paths of fruition.

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“…Slow breathing exercises have been reported to improve vagal tone and decrease sympathetic tone [30, 31], especially in prehypertensives [32]. Moreover, prior studies by Parati et al have demonstrated antihypertensive effects of music-guided slow breathing exercises [33, 34]. Therefore, it is proposed that the offspring of hypertensive parents should regularly practice these breathing exercise programs and maintain their sympathovagal homeostasis to prevent the development of prehypertension.…”

Section: Discussionmentioning

confidence: 99%

Sympathovagal Imbalance in Prehypertensive Offspring of Two Parents versus One Parent Hypertensive

Pal

Nanda

et al. 2011

International Journal of Hypertension

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Objective. Though prehypertension has strong familial predisposition, difference in pathophysiological mechanisms in its genesis in offspring of both parents and single parent hypertensive have not been elucidated. Methods. Body mass index (BMI), waist-hip ratio (WHR), basal heart rate (BHR), blood pressure (BP), HR and BP response to standing, deep breathing difference, BP response to handgrip and spectral indices of heart rate variability (HRV) were analyzed in normotensive offspring of two parents hypertensive (Group I), normotensive offspring of one parent hypertensive (Group II), prehypertensive offspring of two parents hypertensive (Group III) and prehypertensive offspring of one parent hypertensive (Group IV). Results. Sympathovagal imbalance (SVI) in prehypertensive offspring was observed due to increased sympathetic and decreased vagal activity. In group III, SVI was more prominent with greater contribution by vagal withdrawal. LF-HF ratio, the marker of SVI was correlated more with diastolic pressure, 30 : 15 ratio and E : I ratio in prehypertensives and the degree of correlation was more in group III prehypertensives. Conclusion. Vagal withdrawal plays a critical role in development of SVI in prehypertensive offspring of hypertensive parents. The intensity of SVI was more in offspring of two parents hypertensive compared to single parent hypertensive.

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Psychological predictors of the antihypertensive effects of music-guided slow breathing

Cited by 32 publications

References 37 publications

Tai Chi Improves Coronary Heart Disease Risk by Inactivating MAPK/ERK Pathway through Serum miR‐126

Tai Chi Improves Coronary Heart Disease Risk by Inactivating MAPK/ERK Pathway through Serum miR‐126

Multidisciplinary Psychosomatic Assessment for UX Design Evaluation

Sympathovagal Imbalance in Prehypertensive Offspring of Two Parents versus One Parent Hypertensive

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