Psychological outcomes of the COVID-19 pandemic in patients with Parkinson’s disease: A systematic review

Nabizadeh, Fardin; Seyedalhosseini, Zahrasadat; Balabandian, Mohammad; Rostami, Mohammad Reza

doi:10.1016/j.jocn.2022.06.017

Cited by 9 publications

(6 citation statements)

References 42 publications

(153 reference statements)

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“…The reported change in perceived walking ability was also smaller when compared with a previous study reporting 3-year changes in PwPD 45. A recent systematic review reported that the severity or the prevalence of psychiatric disturbance (eg, depressive symptoms) increased due to the COVID-19 pandemic in PwPD 46. Balance impairments and depressive symptoms have previously also been found to be independent predictors of reduction in PA during the pandemic in older adults in Sweden 26…”

Section: Discussionmentioning

confidence: 67%

“…45 A recent systematic review reported that the severity or the prevalence of psychiatric disturbance (eg, depressive symptoms) increased due to the COVID-19 pandemic in PwPD. 46 Balance impairments and depressive symptoms have previously also been found to be independent predictors of reduction in PA during the pandemic in older adults in Sweden. 26 Age (<70 years), higher perceived walking ability, and level of education were identified as independent predictors of sustained PA during the pandemic in PwPD.…”

Section: Discussionmentioning

confidence: 97%

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Predictors of Sustained Physical Activity During the COVID-19 Pandemic in People With Parkinson Disease in Sweden

Conradsson

Leavy

Hagströmer

et al. 2023

Journal of Neurologic Physical Therapy

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Background and Purpose: During the first wave of the COVID-19 pandemic, people with Parkinson disease (PwPD) reported deterioration in health and physical activity. The aim of this study was to describe 1-year changes in physical activity and perceived health in PwPD during the COVID-19 pandemic and to identify predictors of sustained physical activity. Methods: This study compared perceived health and sensor-derived physical activity (Actigraph GT3x) in PwPD between the first (June to July 2020) and third waves (June to July 2021) of the pandemic. Multiple logistic regression analyses were used to predict sustained physical activity across the study period using personal factors, disease severity, and functioning as independent variables. Results: Sixty-three PwPD (mean age 71.0 years, 41% females) completed both baseline and 1-year follow-up (26 lost to follow-up). PwPD showed a decrease in average number of steps per day (Δ415 steps, P = 0.048), moderate-to-vigorous-physical activity (Δ7 minutes, P = 0.007) and increase in sedentary time (Δ36 minutes, P <.001) between baseline and 1-year follow-up. While self-perceived walking impairments and depressive symptoms increased significantly, balance confidence decreased between baseline and 1-year follow-up, no significant changes occurred for self-rated health, quality of life, or anxiety. Significant predictors of sustained physical activity levels were 15 years or more of education (odds ratio [OR] = 7.38, P = 0.013) and higher perceived walking ability (OR = 0.18, P = 0.041). Discussion and Conclusion: Among PwPD with mild to moderate disease severity living in Sweden, factors associated with reduced physical activity levels during the COVID-19 pandemic included older age, lower education levels, and greater perceived walking difficulties. Video Abstract available for more insights from the authors (see the Video, the Supplemental Digital Content, available at: http://links.lww.com/JNPT/A451).

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Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 97%

Predictors of Sustained Physical Activity During the COVID-19 Pandemic in People With Parkinson Disease in Sweden

Conradsson

Leavy

Hagströmer

et al. 2023

Journal of Neurologic Physical Therapy

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“…COVID-19 is a mild to moderate and self-limited illness in most cases and it is caused by severe acute respiratory syndrome coronavirus-2 (SARS-COV-2), a novel coronavirus (1,2). Currently, more than 755 million confirmed cases are reported by WHO worldwide (3). However, most of the studies have focused on respiratory symptoms and neurological manifestations have been increasingly reported (4,5).…”

Section: Introductionmentioning

confidence: 99%

Neuroimaging findings of COVID-19: a systematic review on longitudinal studies

Nabizadeh,

Fallahi,

Zafari

et al. 2024

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Background: There is high number of evidence regarding the involvement of the central nervous system (CNS) in patients with severe acute respiratory syndrome coronavirus-2 (SARS-COV-2). The aim of our systematic review study is to evaluate the current state of knowledge regarding neuroimaging findings after COVID-19 by focusing on longitudinal studies. By limiting our review to this type of study design, we aimed to provide a more comprehensive and detailed picture of the long-term effects of COVID-19 on the brain. Methods: Three electronic databases (PubMed, Scopus, and Web of Science) were searched for relevant studies. We included studies that investigated longitudinal brain changes in patients with COVID-19 with available neuroimaging findings at least two different times. Results: After a two-step review, 10 studies were included in our qualitative synthesis. Brain MRI was the only imaging modality in seven studies, whereas one used only FDG-PET, one used CT/MRI, and one used CT/MRI/FDG-PET. Our results demonstrated consistent evidence of lesions, white matter microstructural, grey matter, metabolism, and blood flow alterations in comparison with healthy controls. Conclusion: Our systematic review provides evidence of widespread microstructural, grey matter, metabolism, and blood flow alterations in patients afflicted with COVID-19. The longitudinal nature of the included studies highlights the importance of ongoing monitoring and follow-up imaging in patients after COVID-19 infection.

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“…Un doubt edly, pa tients with COVID-19 may ex pe rience psy chi at ric symp toms, in clud ing psy cho sis [1][2][3], but to date there is a lack of spe cific ev i dence from clin i cal trials. Chaudhary AMD et al re cently pub lished a sys tem atic re view to eval u ate the oc cur rence of new-on set psy cho sis or ex ac er ba tion of clin i cally sta ble psy cho sis dur ing COVID-19; as the au thors could not find any spe cific clin ical tri als, they in cluded 57 unique case re ports and case series [3].…”

mentioning

confidence: 99%

“…Pa tients with neurodegenerative dis or ders such as Parkin son's dis ease (PD) ap pear to be more vul ner a ble to men tal health dis or ders such as stress, de pres sion, anx i ety, or wors en ing qual ity of life dur ing COVID-19 lockdown. Nabizadeh F et al pub lished a sys tem atic re view of 21 studies with a to tal of 5236 PD cases on psy cho log i cal out comes of COVID-19 [2]: most of the stud ies dem onstrated the in crease of the se ver ity or the prev a lence of psychi at ric dis tur bance due to the COVID-19 pan demic in PD pa tients (the prev a lence of anx i ety was 14.0-66.5%, depres sion 0-50%, ap a thy 0-50%, im pulse con trol dis or ders 44%, sleep prob lems 35.4-68.9%), but they did not cover psy chotic events. There is still a lack of stud ies on the preva lence of psy chotic events in PD pa tients with COVID-19.…”

mentioning

confidence: 99%

Psychosis as an Isolated Manifestation of COVID-19 in Non-Demented Patients with Parkinson's Disease: Clinical Cases and Literature Review

Lokominaitė,

Kaladytė Lokominienė

2023

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Psychotic disorders in patients with Parkinson's disease are usually associated with poor cognitive performance, comorbidities, and changes in treatment regime. Despite the recognition of cognitive deficit as a major risk factor for psychosis in Parkinson's disease, psychotic events have been reported in patients without dementia. SARS-CoV-2 is now recognized as a harmful invader of the nervous system, and defining its consequences still requires multidirectional research. Patients with Parkinson's disease may develop psychosis during COVID-19 infection. According to our observation, psychotic disorder seems to be an isolated manifestation of SARS-CoV-2 infection in Parkinson's disease. In this article, we present two clinical cases of non-demented patients with Parkinson's disease who underwent full vaccination against SARS-CoV-2. The patients were on stable antiparkinsonian medication, had no previous psychiatric disturbances, and developed psychosis as a consequence of COVID-19 without any other clinical signs of infection; no recurrent psychotic disorders were registered during the one-year follow-up. The discussion on diagnostic difficulties and treatment options includes a review of the literature. We recommend to perform reverse transcription polymerase chain reaction (RT-PCR) swab testing for SARS-CoV-2 in patients with Parkinson's disease who develop acute psychosis.

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Psychological outcomes of the COVID-19 pandemic in patients with Parkinson’s disease: A systematic review

Cited by 9 publications

References 42 publications

Predictors of Sustained Physical Activity During the COVID-19 Pandemic in People With Parkinson Disease in Sweden

Predictors of Sustained Physical Activity During the COVID-19 Pandemic in People With Parkinson Disease in Sweden

Neuroimaging findings of COVID-19: a systematic review on longitudinal studies

Psychosis as an Isolated Manifestation of COVID-19 in Non-Demented Patients with Parkinson's Disease: Clinical Cases and Literature Review

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