Psychological issues in breast cancer survivors confronted with motherhood: Literature review and a call to action

Mattei, Valentina Elisabetta Di; Perego, Gaia; Taranto, Paola; Mazzetti, Martina; Ferrari, Federica; Derna, Noemi; Peccatori, Fedro Alessandro; Mangili, Giorgia; Candiani, Massimo

doi:10.3389/fpsyg.2023.1133204

Cited by 9 publications

(11 citation statements)

References 85 publications

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“…Reliable evidence regarding breastfeeding in women with a history of breast cancer is currently unavailable. Guidelines by the Society of Obstetricians and Gynecologists of Canada (SOGC) state that women should be encouraged to breastfeed since there is no evidence that breastfeeding increases the risk of relapse or development of a novel tumor or that it endangers infant health [ 118 ]. According to a study published in The Lancet , the total incidence of breast cancer in developed countries could be reduced by half (2.7 from 6.3 per 100 women up to 70 years old) if women had the mean number of births and duration of breastfeeding common in developing countries [ 119 , 120 ].…”

Section: Malignancies and Breastfeedingmentioning

confidence: 99%

“…According to a study published in The Lancet , the total incidence of breast cancer in developed countries could be reduced by half (2.7 from 6.3 per 100 women up to 70 years old) if women had the mean number of births and duration of breastfeeding common in developing countries [ 119 , 120 ]. Breastfeeding represents almost 2/3 of the estimated decrease in breast cancer prevalence [ 118 ]. The observed protection is related to hormonal changes during lactation, which delay menstruation and reduce exposure to estrogens that are associated with risk of breast cancer [ 121 ].…”

Section: Malignancies and Breastfeedingmentioning

confidence: 99%

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Knowledge Gaps and Current Evidence Regarding Breastfeeding Issues in Mothers with Chronic Diseases

et al. 2023

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The prevalence of chronic maternal disease is rising in the last decades in the developed world. Recent evidence indicated that the incidence of chronic maternal disease ranges from 10 to 30% of pregnancies worldwide. Several epidemiological studies in mothers with chronic diseases have mainly focused on the risk for adverse obstetric outcomes. Evidence from these studies supports a correlation between maternal chronic conditions and adverse perinatal outcomes, including increased risk for preeclampsia, cesarean section, preterm birth, and admission in the Neonatal Intensive Care Unit (NICU). However, there is a knowledge gap pertaining to the management of these women during lactation. This review aimed at summarizing the available research literature regarding breastfeeding in mothers with chronic diseases. Adjusted and evidence-based support may be required to promote breastfeeding in women with chronic diseases; however, our comprehension of breastfeeding in this subpopulation is still unclear. The literature related to breastfeeding extends in various scientific areas and multidisciplinary effort is necessary to compile an overview of current evidence and knowledge regarding breastfeeding issues in mothers with chronic diseases.

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Section: Malignancies and Breastfeedingmentioning

confidence: 99%

Section: Malignancies and Breastfeedingmentioning

confidence: 99%

Knowledge Gaps and Current Evidence Regarding Breastfeeding Issues in Mothers with Chronic Diseases

et al. 2023

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“…[16,17] Breast cancer survivors confront challenges that extend beyond the physical aspects of their illness. [18,19] The preservation of their psychological well-being and QOL becomes paramount, given the toll that breast cancer and its treatments exact on these dimensions of life. Depression is a prevalent concern among breast cancer patients, with rates ranging from 9.3% to as high as 56%.…”

Section: Introductionmentioning

confidence: 99%

Assessing quality of life and depression in non-metastatic breast cancer patients following surgical treatment: A cross-sectional study in Lebanon

Nahle,

Hamdar,

Awada

et al. 2024

Medicine

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Breast cancer is a global health concern that significantly impacts the quality of life (QOL) of individuals. This study aims to comprehensively examine the interplay between QOL and depression among nonmetastatic breast cancer patients in Lebanon, a region with limited research in this context. A cross-sectional study was conducted at Hammoud Hospital-University Medical Center from January 2018 to January 2023. Data was collected through a self-administered questionnaire distributed as Google Forms via WhatsApp. A total of 193 patients had non-metastatic breast cancer. Out of these, 81 valid responses were obtained. The Patient Health Questionnaire and Quality of Life Scale were used to assess depression and QOL, respectively. A total of 81 patients were included with mean age 54.4 years. Results revealed that 77.8% of patients experienced provisional depression, with 35.8% meeting criteria for major depressive disorder. Financial status and chronic diseases were associated with the likelihood of developing major depressive disorder. The mean QOL score was 81.14, lower than the average for healthy individuals. Educational level and presence of chronic diseases were significant factors influencing QOL. Postsurgical depression prevalence is substantial, underscoring the importance of integrating mental health care. Economic status and comorbidities are influential factors, necessitating targeted interventions. Breast cancer’s impact on QOL is profound, falling below that of other chronic conditions. Education empowers coping, while comorbidities impact QOL. Our findings emphasize the multidimensional nature of breast cancer care, advocating for holistic support and addressing emotional well-being.

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“…It is known that cancer in young patients differs from that in older people in the aggressiveness of the clinical course, histological structure, and molecular profile. It is known that young women have a higher risk of recurrence, the development of secondary BCa, as well as lower survival rates [1]. Young BCa patients also have a high frequency of the triple-negative (basal) molecular BCa subtype, which is characterized by an aggressive course and low sensitivity to chemotherapy [2].…”

mentioning

confidence: 99%

Pattern of Mmp2 and Mmp9 Expression Depends on Breast Cancer Patients’ Age

Lukianova,

Mushii,

Borikun

et al. 2023

Exp. oncol.

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Background: Despite the large number of studies devoted to the study of the features of tumor microenvironment in breast cancer (BCa), presently there is no consensus on the features of MMP-2 and MMP-9 expression in the tumor tissue of BCa patients depending on the age. The aim of the study was to investigate the relationship between MMP-2 and -9 expression at the protein and mRNA levels in BCa tissues and the clinical and pathological features of BCapatientsin different age groups. Materials and Methods: The expression level of MMP-2 and -9in the BCa tissue of patients of two age groups (< 45 years and > 45 years) was studied using the bioinformatics method (UALCAN database), immunohistochemical method, and real-time PCR. Results: It was established that a characteristic feature of BCa in young patients is the low level of MMP2 mRNA against the background of increased expression of this gelatinase at the protein level, as well as decreased expression of MMP9 at both the mRNA and protein levels. When analyzing the correlation of the gelatinase expression indices in BCa tissue of young patients, depending on the clinical and pathological features, a significantly lower level of MMP-2 expression was recorded in BCa cases of stage II compared to the indices of stage I cases. High expression of MMP-2 and -9 was recorded in BCa tissue in node-positive cases and the basal molecular BCa subtype. Conclusions: The identified relationship between the expression of the studied gelatinases and such indices of BCa malignancy as its stage, positive regional lymph node status, and the molecular BCa subtype in young patients indicates the need for further research of the features of the tumor microenvironment to predict the cancer aggressiveness.

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Psychological issues in breast cancer survivors confronted with motherhood: Literature review and a call to action

Cited by 9 publications

References 85 publications

Knowledge Gaps and Current Evidence Regarding Breastfeeding Issues in Mothers with Chronic Diseases

Knowledge Gaps and Current Evidence Regarding Breastfeeding Issues in Mothers with Chronic Diseases

Assessing quality of life and depression in non-metastatic breast cancer patients following surgical treatment: A cross-sectional study in Lebanon

Pattern of Mmp2 and Mmp9 Expression Depends on Breast Cancer Patients’ Age

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