Psychological factors in prurigo nodularis in comparison with psoriasis vulgaris: results of a case-control study

Abstract

The hypotheses formulated in the literature on the specific aetiology of PN could not be proven for the majority of patients with PN in our study. Concerning their psychopathology, patients with PN were comparable with those with psoriasis. Therefore the clinical management of PN should include psychosomatic assessment.

Health-Related Quality of Life in Chronic Pruritus: An Analysis Related to Disease Etiology, Clinical Skin Conditions and Itch Intensity

“…However, no significant correlation of HRQoL was observed, neither related to the type of clinical skin lesion (group I or II) nor the type of underlying disease category (dermatological, mixed or unknown causes). This is in line with previous analyses that demonstrated no difference in burden between prurigo and dermatoses such as eczema (related to single quality of life items in a pruritus questionnaire) [20] or psoriasis (related to psychopathological profile) [26]. Also, no previous study investigated DLQI in a large number of PN patients except in single trials.…”

Serotonin and interleukin-6: Association with pruritus severity, sleep quality and depression severity in Prurigo Nodularis

“…The percentage of depressed was higher in PN group. Depression rates and severity may be higher in PN when compared to healthy controls but may not be different from that seen associated with other chronic skin conditions like psoriasis (Schneider et al, 2006;Dazzi et al, 2011). As we had taken healthy controls, our study cannot be compared with the latter part.…”

Dr. Roubille, et al reply

“…We agree that, unfortunately, research on depression screening and management is lacking. Our article was a comprehensive literature review identifying multiple studies that demonstrated that the prevalence of depression in patients with psoriatic disease and RA was higher compared with control groups 9,10,11,12,13,14,15,16,17 . A published metaanalysis that helped corroborate our finding reported an overall depression prevalence of 28% in PsO and that patients with PsO were more likely to have depression than those without PsO (OR 1.57, 95% CI 1.40-1.76) 18 .…”