Psychological distress in patients with moderate to severe chronic graft-versus-host disease (cGVHD).

Waldman, Lauren; Traeger, Lara; Fishman, Sarah; Markovitz, Netana H.; Vanderklish, Julie; Chen, Yi-Bin Albert; Spitzer, Thomas R.; Temel, Jennifer S.; El‐Jawahri, Areej

doi:10.1200/jco.2018.36.15_suppl.e22137

Cited by 2 publications

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“…Several studies have previously reported psychological distress among patients with chronic GVHD, 16 , 23 , 26 , 27 and the physical symptoms of chronic GVHD may be substantial contributors to mental health issues. In a prospective observational cohort study from the Chronic GVHD Consortium, patients with self‐reported depression and anxiety symptoms (per the LSS psychological subscale) had higher overall chronic GVHD symptom burden and worse QoL compared with patients without depression or anxiety symptoms.…”

Section: Discussionmentioning

confidence: 99%

Patient‐reported symptom burden and impact on daily activities in chronic graft‐versus‐host disease

Hamilton

Turnbull

et al. 2022

Cancer Medicine

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Background Chronic graft‐versus‐host disease (GVHD) is a potentially life‐threatening complication of allogeneic hematopoietic stem cell transplantation (HSCT) treatment for hematologic malignancies. There are limited patient‐reported data concerning symptom burden and effects on activities of daily living (ADL). Methods The cross‐sectional Living With Chronic GVHD Patient Survey was administered online in the United States (May–August 2020) to participants aged ≥18 years who underwent allogeneic HSCT, were diagnosed with chronic GVHD by a healthcare provider, and self‐reported active chronic GVHD (within past 5 years). Information on patient demographics, disease characteristics, symptom burden, and ability to perform ADL was collected. Symptom burden was assessed using the validated Lee Symptom Scale (range from 0–100 with higher scores indicating greater burden). All data were summarized using descriptive statistics; no formal statistical comparisons were conducted. Results Out of 580 participants who entered the survey screener, 165 participants (28.4%) across 33 states fulfilled all study eligibility criteria, completed the entire survey, and were included (age: mean [SD], 53.7 (13.8) years; median [range], 57.0 [18–78] years; female, n = 105 [63.6%]; White, n = 137 [83.0%]). Respondents described their chronic GVHD severity primarily as moderate ( n = 54 [32.7%]) or severe ( n = 102 [61.8%]) at the time when symptoms were at their worst. One‐third of respondents (33.9%) indicated that their chronic GVHD symptoms were at their worst for ≥1 year in duration. Mean (SD; range) Lee Symptom Scale score was 44.8 (19.4; 2–100); 44% of respondents considered “dry eye” the most burdensome symptom. Almost half of respondents ( n = 73 [44.2%]) rated their overall quality of life (QoL) as poor. Participants reported a detrimental impact of symptoms on ADL, including basic activities (eg, eating, personal hygiene, dressing). Conclusions Survey respondents self‐reported high chronic GVHD symptom burden and felt that their symptoms severely interfered with physical function and ADL. Effective strategies to mitigate chronic GVHD symptoms are needed to improve QoL among HSCT survivors.

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Section: Discussionmentioning

confidence: 99%

Patient‐reported symptom burden and impact on daily activities in chronic graft‐versus‐host disease

Hamilton

Turnbull

et al. 2022

Cancer Medicine

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“…Multiorgan involvement after hematopoietic stem cell transplantation (HSCT) in patients with graft-versus-host disease (GVHD) is not a new phenomenon, and it has been reported in literature for several decades [ 1 ]. Physical disabilities [ 2 , 3 ], poor quality of life [ 4 ], psychological impact [ 5 ], and increased mortality associated with GVHD are well documented and acknowledged by transplant clinicians worldwide [ 6 ]. Due to such diverse organ involvement, several organizations, including the Haemato‐oncology subgroup of the British Committee for Standards in Haematology and the British Society for Bone Marrow Transplantation, put forward recommendations on the importance of a multidisciplinary approach and involvement of organ-specific specialists for managing post-HSCT complications [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Recommendations on service delivery to help reduce suffering and anxiety in patients and caregivers post-hematopoietic cell transplantation: a case report

Mohammed

Bakhsh

Craig³

et al. 2021

J Med Case Reports

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Background The aim of this study is to highlight the importance of having a central case managing team and to make some strong recommendations that can have a positive impact on the lives of hematopoietic stem cell transplantation survivors. Case presentation A 2-year-old white child who was diagnosed with acute myeloid leukemia and underwent hematopoietic stem cell transplantation in May 2014 relapsed in March 2017, and underwent a second hematopoietic stem cell transplantation in July 2017, at which point he suffered from graft-versus-host disease. This case report presents his journey and that of his caregivers, and the challenges they faced as patient and parents in pursuit of optimal quality of life during the survivorship period. The case study emphasizes not only the challenges faced by patients but also identified gaps in post-hematopoietic cell transplantation care service delivery. Furthermore, the case study also highlights the importance of involving caregivers in post-transplant care and having a better communication process and service facilitation process throughout the journey of the patient and their carer. Conclusions Transplant centers have a duty of care, and a proactive approach with a well-defined pathway is needed for managing post-transplant complications and reducing stress and anxiety for patients and their caregivers.

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Psychological distress in patients with moderate to severe chronic graft-versus-host disease (cGVHD).

Cited by 2 publications

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Patient‐reported symptom burden and impact on daily activities in chronic graft‐versus‐host disease

Patient‐reported symptom burden and impact on daily activities in chronic graft‐versus‐host disease

Recommendations on service delivery to help reduce suffering and anxiety in patients and caregivers post-hematopoietic cell transplantation: a case report

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