Psychological distress, depressive symptoms, and cellular immunity among healthy individuals: A 1-year prospective study

Nakata, Akinori; Irie, Masahiro; Takahashi, Masaya

doi:10.1016/j.ijpsycho.2011.06.009

Cited by 12 publications

(16 citation statements)

References 42 publications

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“…These studies found that workers who maintained low job satisfaction levels had worse immune status than those who had not, as evidenced by higher levels of proinflammatory markers and lower NK cell immunity. The result of this study is also in line with past researches which reported that exposure to high job stress is associated with reduction of NK cells and NKCC 19,[24][25][26][27][28] as well as increased proinflammatory markers such as CRP, IL-6, total leukocytes, and B cells among variety of occupations 20,[29][30][31] . As a result of exposure to chronic job stress, employees may become more dissatisfied with their work manifesting immune disruption.…”

Section: Discussionsupporting

confidence: 91%

“…Immunofluorescence staining analysis was conducted within 24 h of blood collection. We determined counts of total leukocytes and total lymphocytes by an automated cell counter (Coulter Counter SP-VI, Coulter Electronics, Hialeah, Florida, USA), lymphocyte subpopulations by flow cytometry analysis (EPICS XL, Beckman Coulter Inc, California, U.S.A.), and plasma IgG concentration by Turbidimetric Immunoassay (Hitachi automatic analyzer 7150, Tokyo, Japan), as described in detail elsewhere 7,[17][18][19][20] .…”

Section: Preparation Of Blood Samplesmentioning

confidence: 99%

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A Single-item Global Job Satisfaction Measure Is Associated with Quantitative Blood Immune Indices in White-collar Employees

2013

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Although a single-item job satisfaction measure has been shown to be reliable and inclusive as multiple-item scales in relation to health, studies including immunological data are few. The purpose of this study was to evaluate the validity of single-item job and family life satisfaction based on its association with immune indices. A total of 189 white-collar employees (70% men) underwent a blood draw for the measurement of natural killer (NK), total T, and B cell counts as well as plasma immunoglobulin (Ig) G concentrations and completed single-item job and family life satisfaction measures, respectively. The response options for satisfaction measures were 'dissatisfied' (coded 1) to 'satisfied' (coded 4). Spearman's partial correlations controlling for cofactors revealed that increased job satisfaction was positively associated with NK cells (rsp=0.201, p=0.007) and IgG (rsp=0.178, p=0.018), while family life satisfaction was unrelated to immune indices. Those who reported a combination of low job/low family life satisfaction had significantly lower NK and higher B cell counts than those with a high job/high family life satisfaction. Our study suggests that the single-item summary measure of job satisfaction, but not family life satisfaction, may be a valid tool to evaluate immune status in healthy white-collar employees.

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Section: Discussionsupporting

confidence: 91%

Section: Preparation Of Blood Samplesmentioning

confidence: 99%

A Single-item Global Job Satisfaction Measure Is Associated with Quantitative Blood Immune Indices in White-collar Employees

2013

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“…To date, a minimal clinical important difference for the CES-D remains unknown, which makes it difficult to interpret these findings. However, a French population study showed mean CES-D changes between À0.4 and þ2.5 points over three years [26], while another study among healthy individuals found a decrease of 1.2 points after one year [27]. Moreover, previous authors studying an intervention in primary care patients with a newly diagnosed depression defined a change of 3.6 points over 6 months as a relevant change [28].…”

Section: Discussionmentioning

confidence: 99%

Persistent systemic inflammation and symptoms of depression among patients with COPD in the ECLIPSE cohort

Janssen

Müllerová

Agustí

et al. 2014

Respiratory Medicine

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“…For example, neighborhood problems such as vandalism, illegal drug use, noise, and litter are sources of psychological stress for residents, 23---25 and psychological stress is known to influence immune function. 26,27 Neighborhood-associated psychological stress could therefore place individuals at increased risk of severe influenza illness. Indeed, Cohen et al demonstrated that among individuals experimentally infected with influenza, those reporting high psychological stress before inoculation experienced more severe illness than did individuals with low stress.…”

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confidence: 99%

The Social Determinants of Health and Pandemic H1N1 2009 Influenza Severity

et al. 2012

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Objectives. We explored the effects of social determinants of health on pandemic H1N1 2009 influenza severity and the role of clinical risk factors in mediating such associations. Methods. We used multivariate logistic regression with generalized estimating equations to examine the associations between individual- and ecological-level social determinants of health and hospitalization for pandemic H1N1 2009 illness in a case-control study in Ontario, Canada. Results. During the first pandemic phase (April 23–July 20, 2009), hospitalization was associated with having a high school education or less and living in a neighborhood with high material or total deprivation. We also observed the association with education in the second phase (August 1–November 6, 2009). Clinical risk factors for severe pandemic H1N1 2009 illness mediated approximately 39% of the observed association. Conclusions. The main clinical risk factors for severe pandemic H1N1 2009 illness explain only a portion of the associations observed between social determinants of health and hospitalization, suggesting that the means by which the social determinants of health affect pandemic H1N1 2009 outcomes extend beyond clinically recognized risk factors.

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Psychological distress, depressive symptoms, and cellular immunity among healthy individuals: A 1-year prospective study

Cited by 12 publications

References 42 publications

A Single-item Global Job Satisfaction Measure Is Associated with Quantitative Blood Immune Indices in White-collar Employees

A Single-item Global Job Satisfaction Measure Is Associated with Quantitative Blood Immune Indices in White-collar Employees

Persistent systemic inflammation and symptoms of depression among patients with COPD in the ECLIPSE cohort

The Social Determinants of Health and Pandemic H1N1 2009 Influenza Severity

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