Psychological correlates of gastric and duodenal ulcer disease

Tennant, Chris; Goulston, Kerry; Langeluddecke, Pauline

doi:10.1017/s0033291700009193

Cited by 27 publications

(15 citation statements)

References 17 publications

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“…Psychological factors, particularly personality traits, anxiety, depression and stressful life events, were associated with PU in some studies (19,20). but not in others (18).…”

Section: Discussionmentioning

confidence: 91%

Peptic Ulcer and Non-ulcer Dyspepsia—a Disease and a Disorder

Johnsen

Straume

Førde

1988

Scandinavian Journal of Primary Health Care

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In a cross-sectional survey for coronary risk factors, 14,390 middle-aged men and women answered a questionnaire concerning life-style, diet and disease, including peptic ulcer (PU) and dyspeptic symptoms. The overall lifetime prevalence of reported PU was 5.3% in men and 2.1% in women. The prevalence of reported dyspeptic symptoms, consistent with non-ulcer dyspepsia (NUD), was 22.6% in men and 18.1% in women. Reporting of both PU and NUD was significantly associated with sex and age, NUD less marked than PU. PU and NUD differed substantially with respect to associations with psychologic, social, life-style, and dietary variables. PU was strongly associated with age, a family history of peptic ulcer, body mass index, and smoking. NUD, on the other hand, showed closest association to psychological factors and social conditions. This difference between PU and NUD might be of aetiological and therefore clinical significance, and calls for therapeutic trials in NUD patients with interventions different from the traditional peptic ulcer treatments.

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“…Psychological factors, particularly personality traits, anxiety, depression and stressful life events, were associated with PU in some studies (19,20). but not in others (18).…”

Section: Discussionmentioning

confidence: 91%

Peptic Ulcer and Non-ulcer Dyspepsia—a Disease and a Disorder

Johnsen

Straume

Førde

1988

Scandinavian Journal of Primary Health Care

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“…Tromso 1979-87. Table 4 The relative risks (RR) (95% confidence intervals (CI) ) for variables significantly contributing to predicting peptic ulcer in a proportional hazard general linear model in 6907 women, censored for annual death and (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16) 11-2 (4-49, 28-0) 3 some degree. The main differences were a stronger association with age and a positive family history for gastric ulcer.…”

Section: Resultsmentioning

confidence: 99%

“…"-1'2 Even the assertion that the risk in men and women is different is questioned. [1][2][3][4][5][6][7][8][9][10][11][12][13][14] Divergent views persist on whether duodenal and gastric ulcer are the same disease with different localisation or separate disease entities. '5116 Helicobacter pylori has recently been introduced as the aetiologic agent in peptic ulcer disease,'7 but several studies have shown that it is also present in 30 to 50% of people without dyspepsia,'7-'9 indicating that its role may not be so important.…”

mentioning

confidence: 99%

Aetiology of peptic ulcer: a prospective population study in Norway.

Johnsen

Førde

Straume

et al. 1994

Journal of Epidemiology & Community Health

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Study objective -To analyse simultaneously the effect of several risk factors for peptic ulcer. Design -Cohort study where all patients with new or incident peptic ulcers in a well defined population were registered for a seven year period. The follow up started with a comprehensive health survey including a questionnaire on diet, lifestyle, psychological and social conditions, and health. Relative risks, both sex specific and separate, for gastric and duodenal ulcers were estimated from proportional hazard regression analysis. Setting -A population based survey conducted in the municipality of Troms0, northern Norway. Participants -In 1980, a total of 21 440 men and women, aged 20 to 54 years and 20 to 49 years respectively, were invited to participate. A total of 14 667 people attended and returned the questionnaire. Main results -A total of 328 people had their first peptic ulcer in the follow up period. Age, cigarette smoking, first degree relatives with peptic ulcer, and low educational level were shared risk factors for peptic ulcer in both men and women. In men, frequent upper respiratory infections increased the risk of gastric ulcer and drinking a great deal of milk increased the risk of duodenal ulcer. None of the other dietary variables, including coffee and alcohol consumption, contributed significantly to the risk. Use of analgesics was not a risk factor, and none of the psychological indicators analysed carried any significant risk.Conclusions -Age, inheritance, and cigarette smoking are all important risk factors for peptic ulcer. The increased risk associated with low educational background indicate that social strains, comprising lifestyle and diet habits, are part of the multifactorial aetiology of

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“…11,12,29,30 Persons with Type-A personality or persons undergoing stressful events may have increased endogenous stress hormone including cortisol and catecholamine, 31,32 which have also been noted to be elevated in patients with CSR. 11,12,29,30 Persons with Type-A personality or persons undergoing stressful events may have increased endogenous stress hormone including cortisol and catecholamine, 31,32 which have also been noted to be elevated in patients with CSR.…”

Section: Discussionmentioning

confidence: 99%