Abstract:BACKGROUND OF PROBLEMIn recent years the literature of gerontology has abounded with the pros and cons of therapy involving the major sex steroids. Yet neither unanimity of experimental evidence nor concurrence of clinical opinion has characterized the field. The relatively early involution of the gonads in comparison to the other organs of the endocrine system impresses one as suggesting more than a casual correlation between their reduced functioning and the many other structural and functional changes by me… Show more
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