Psychobiotics: The Potential Therapeutic Promise of Microbes in Psychiatry

Sayar, Assoc. Prof. Gokben Hizli; Çetin, Mesut

doi:10.5455/bcp.20160531111208

Cited by 5 publications

(2 citation statements)

References 72 publications

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“…Of the remaining 10 articles in the corpus, all of which were review articles, four describe alterations in plasma levels of lipopolysaccharide (LPS), a molecule found in gram-negative bacteria exterior cell walls, and/or β-methylamino- l -alanine (BMAA), a neurotoxic nonessential amino acid metabolite of cyanobacteria, in ALS (Bengmark, 2013; Catanzaro et al, 2015; Fröhlich-Nowoisky et al, 2016; Sayar & Cetin, 2016). These papers suggest that translocation of gram-negative bacteria, in particular cyanobacteria, across the gut epithelial cell barrier plays a role in ALS pathophysiology.…”

Section: Resultsmentioning

confidence: 99%

Potential Role of the Gut Microbiome in ALS: A Systematic Review

Wright

Fournier

Houser

et al. 2018

Biological Research For Nursing

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Amyotrophic lateral sclerosis (ALS) etiology and pathophysiology are not well understood. Recent data suggest that dysbiosis of gut microbiota may contribute to ALS etiology and progression. This review aims to explore evidence of associations between gut microbiota and ALS etiology and pathophysiology. Databases were searched for publications relevant to the gut microbiome in ALS. Three publications provided primary evidence of changes in microbiome profiles in ALS. An ALS mouse model revealed damaged tight junction structure and increased permeability in the intestine versus controls along with a shifted microbiome profile, including decreased levels of butyrate-producing bacteria. In a subsequent publication, again using an ALS mouse model, researchers showed that dietary supplementation with butyrate relieved symptoms and lengthened both time to onset of weight loss and survival time. In a small study of ALS patients and healthy controls, investigators also found decreased levels of butyrate-producing bacteria. Essential for maintaining gut barrier integrity, butyrate is the preferred energy source of intestinal epithelial cells. Ten other articles were reviews and commentaries providing indirect support for a role of gut microbiota in ALS pathophysiology. Thus, these studies provide a modicum of evidence implicating gut microbiota in ALS disease, although more research is needed to confirm the connection and determine pathophysiologic mechanisms. Nurses caring for these patients need to understand the gut microbiome and its potential role in ALS in order to effectively counsel patients and their families about emerging therapies (e.g., prebiotics, probiotics, and fecal microbial transplant) and their off-label uses.

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Section: Resultsmentioning

confidence: 99%

Potential Role of the Gut Microbiome in ALS: A Systematic Review

Wright

Fournier

Houser

et al. 2018

Biological Research For Nursing

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“…It was expanded to include prebiotics as growth enhancers for beneficial gut bacteria [26]. It can also be expanded to include postbiotics, which are the metabolic by-products of probiotics and have beneficial biological activity in the host [27]. Finally, it was agreed that the concept should include any exogenous influence whose effect on the brain is bacterially mediated [26].…”

Section: Psychobioticsmentioning

confidence: 99%

Bifidobacteria and Psychobiotic Therapy: Current Evidence and Future Prospects

Altaib

Badr

Suzuki

2021

RAS

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Mounting evidence elucidates the impact of gut microbiota on the maintenance of host's physical and psychological conditions. The gut microbiota can produce its effects through neural, endocrine, and immune pathways. Specific gut members, such as lactobacilli and bifidobacteria, have shown unique abilities to affect the host's mental health, and hence, they are called psychobiotics. Several studies, on both rodents and humans, have confirmed the role of Bifidobacterium in the regulation of anxiety, mood, cognition, and pain. Here, we summarize the currently available evidence that suggests the roles of bifidobacteria in gut microbiota-brain communication and highlight the prospects of this research field. The action of Bifidobacterium has been found to be strain specific. We discuss here the currently reported mechanisms of action of different Bifidobacterium strains. However, more strategic investigations are needed to fully understand the detailed mechanisms of action of Bifidobacterium as psychobiotic bacteria.

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Potential Role of Probiotics on Gut Microbiota in Neurological Disease

Jose

Aliya²

2022

Nutritional Neurosciences

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Psychobiotics: The Potential Therapeutic Promise of Microbes in Psychiatry

Cited by 5 publications

References 72 publications

Potential Role of the Gut Microbiome in ALS: A Systematic Review

Potential Role of the Gut Microbiome in ALS: A Systematic Review

Bifidobacteria and Psychobiotic Therapy: Current Evidence and Future Prospects

Potential Role of Probiotics on Gut Microbiota in Neurological Disease

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