Psychobiotics: The Next-Generation Probiotics for the Brain

Sharma, Richa; Gupta, Deepak; Mehrotra, Rekha; Mago, Payal

doi:10.1007/s00284-020-02289-5

Cited by 70 publications

(93 citation statements)

References 83 publications

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“…With advancement in molecular techniques for microflora characterization and isolation, new probiotics with additional health-promoting functions can be designed. For instance, psychobiotics as a special class of probiotics can deliver mental health benefits to individuals (Sharma et al , 2021), and this feature can be the subject of future probiotic functional foods. In the current manner, dairy products such as yogurt, cheese, fermented milk and kefir have a high impact on probiotic research related to food science.…”

Section: Resultsmentioning

confidence: 99%

Worldwide research tendencies on probiotics in food science: 1993 to 2021

Albayrak

Duran

2021

BFJ

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PurposeThis study aimed to identify the main and emerging structural patterns in the growth of the literature on probiotic research in food science, analyze current trends and determine gaps and present future projections.Design/methodology/approachA total of 1,301 scientific documents retrieved from Scopus database dated from 1993 to 2021 were analyzed by using bibliometric and scientometric tools.FindingsThe most influencer journals, leading countries and hotspots were identified by scientometric mapping. “Lactic acid bacteria”, “lactobacillus”, “lactobacillus plantarum”, “viability”, “functional foods” and “microencapsulation” were the top keywords that indicate main emerging areas. After a clear understanding of the current situation, future directions can be better projected. Therefore, investigating new probiotic microorganisms with advanced health promoting properties, adapting the new organisms to various food formulations, identifying the probiotic potential of unexplored traditional fermented foods and developing of nondairy probiotic foods can be the studies of the future.Research limitations/implicationsProbiotic concept has been revised during years and valuable knowledge has been accumulated over past decades. The findings demonstrate the development and trends of probiotic related food science researches. This is the first study to address the limitations of prior systematic literature reviews by applying network analysis and guide future works to fill the identified gaps.Originality/valueThe probiotic concept has been revised for years and valuable knowledge has been accumulated. Within the expanding literature, scientometric and bibliometric analysis will provide valuable contribution for identifying the main patterns, analyzing current trends, determining gaps and presenting future projection. This work presents detailed analysis to determine tendencies in probiotic research in food science.

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Section: Resultsmentioning

confidence: 99%

Worldwide research tendencies on probiotics in food science: 1993 to 2021

Albayrak

Duran

2021

BFJ

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“…Although intestinal functionality is regulated to maintain homeostasis, adaptation is possible for environmental conditions such as stress [ 19 ]. The ENS connects to the CNS (including the brain) through the vagus nerve [ 20 ], thus allowing the brain to sense the environment within the gut.…”

Section: Pathways Of Communication Along the Microbiota–gut–brain Axismentioning

confidence: 99%

“…The vagus nerve functions both as a signaling pathway and transfers metabolites and other components to the brain [ 21 ]. The vagus nerve responds to components produced or induced by the gut microbiota, such as short chain fatty acids (SCFA), endotoxins, peptides, and cytokines [ 20 ]. Furthermore, neurotransmitters such as serotonin produced within the gut influence vagal functionality [ 23 ].…”

Section: Pathways Of Communication Along the Microbiota–gut–brain Axismentioning

confidence: 99%

“…Inflammatory responses and impairment of intestinal barrier function often go hand in hand. The induction of proinflammatory cytokines, such as interleukin (IL)-1β, IL-6, IL-18, and tumor necrosis factor (TNF)-α, have all been associated with depression [ 20 , 25 ] and increased peripheral inflammation has been observed in many psychiatric diseases such as depression, anxiety, and even autism spectrum disorder (reviewed in [ 26 ]). Circulating cytokines can access the brain through direct transportation across the blood–brain barrier (BBB).…”

Section: Pathways Of Communication Along the Microbiota–gut–brain Axismentioning

confidence: 99%

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One Giant Leap from Mouse to Man: The Microbiota–Gut–Brain Axis in Mood Disorders and Translational Challenges Moving towards Human Clinical Trials

et al. 2022

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The microbiota–gut–brain axis is a bidirectional communication pathway that enables the gut microbiota to communicate with the brain through direct and indirect signaling pathways to influence brain physiology, function, and even behavior. Research has shown that probiotics can improve several aspects of health by changing the environment within the gut, and several lines of evidence now indicate a beneficial effect of probiotics on mental and brain health. Such evidence has prompted the arrival of a new term to the world of biotics research: psychobiotics, defined as any exogenous influence whose effect on mental health is bacterially mediated. Several taxonomic changes in the gut microbiota have been reported in neurodevelopmental disorders, mood disorders such as anxiety and depression, and neurodegenerative disorders such as Alzheimer’s disease. While clinical evidence supporting the role of the gut microbiota in mental and brain health, and indeed demonstrating the beneficial effects of probiotics is rapidly accumulating, most of the evidence to date has emerged from preclinical studies employing different animal models. The purpose of this review is to focus on the role of probiotics and the microbiota–gut–brain axis in relation to mood disorders and to review the current translational challenges from preclinical to clinical research.

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“…27 Finally, a special class of probiotics, the psychobiotics, has been recently defined based on their ability to produce or stimulate the production of neurotransmitters, enteroendocrine hormones and other molecules, with a large range of applications, including mood and stress alleviation. 39 A beneficial role for probiotics in mitigating anti-depressive effects, both as an adjunct to antidepressant drugs or as a stand-alone intervention, has been recently suggested elsewhere. 40 This is of course an interesting field with huge potentialities; however, the administration of psychobiotics in the general population should be carefully evaluated and supported by more evidence.…”

Section: Introductionmentioning

confidence: 99%

Food supplements to complement brain functioning: the benefits of a combination of magnesium, folic acid, omega-3 fatty acids and vitamin E

Businaro

2022

F1000Res

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Diet and nutrition play a fundamental role not only in human body composition and in physiology, but have also relevant effects on mood, mental well-being and cognitive performance. In particular, the preservation of mental well-being through a healthy lifestyle, including a well-balanced diet and, in case, through the intake of specific food supplements, is of particular relevance in the perspective of global human ageing, as the brain is affected significantly by a persistent presence of stress factors. Due to the increasing burden of mental and neurological disorders and to the universality of food as a modifiable risk factor, even limited improvements in nutritional habits may translate to a considerable rise of well-being and mental health in the global population. Moreover, the use of targeted, well-balanced food supplements aiming to support the mental health and well-being will probably represent a relevant tool in future decades, together with an increased awareness of the importance of nutrition, also considering the COVID-19 pandemic and the related stressful events and limitations we are still experiencing at global level. The aim of this review is to summarize the experimental and clinical data reported in the literature concerning the beneficial effects of a subset of micro- and macronutrients contained both in food and in supplements, namely magnesium, folic acid, docosahexaenoic acid, eicosapentaenoic acid, and alpha-tocopherol, on a series of disorders, including stress, anxiety, low sleep quality, and low cognitive performance.

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Psychobiotics: The Next-Generation Probiotics for the Brain

Cited by 70 publications

References 83 publications

Worldwide research tendencies on probiotics in food science: 1993 to 2021

Worldwide research tendencies on probiotics in food science: 1993 to 2021

One Giant Leap from Mouse to Man: The Microbiota–Gut–Brain Axis in Mood Disorders and Translational Challenges Moving towards Human Clinical Trials

Food supplements to complement brain functioning: the benefits of a combination of magnesium, folic acid, omega-3 fatty acids and vitamin E

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