Psychobiology of Sexual Behavior in the Guinea Pig

Young, William C.

doi:10.1016/s0065-3454(08)60068-6

Cited by 92 publications

(61 citation statements)

References 125 publications

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“…Because co-receptors appear to play an important role in the regulation of these processes in adulthood, we mea sured «i-receptors at 1,7,14,21, and 60 days in guinea pigs. Because puberty occurs at about 45-60 days [22], these ages represent several prepubertal points in development, and one point in early adulthood.…”

Section: Experiments 1: Ontogeny Of Ai-receptor In the Male Guinea Pigmentioning

confidence: 99%

“…One possible mechanism is through an effect of steroids on rxi-receptor number. Direct or indirect effects of steroids on serotonin In this study, we examined the ontogeny of ai-receptors from birth to 60 days of age in several brain regions of intact male guinea pigs in order to correlate these receptor data Received: June 3,1983 Accepted after revision: August 29,1983 with the known profile of androgen secretion [19] and onset of male behavior patterns [22], In addition, we examined the effect of adult and neonatal castration on ai-receptors pres ent in adulthood. …”

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confidence: 99%

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Hypothalamic and Preoptic Area α1-Receptor Concentrations Decrease, and Cerebral Cortical α1-Receptor Concentrations Increase during Postnatal Maturation of Male Guinea Pigs

Johnson¹,

Nock²,

Ryer³

et al. 1984

Neuroendocrinology

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α₁ -Receptors were measured in intact male guinea pigs during the course of postnatal development. Receptor concentrations were significantly higher at day 1 in hypothalamus and at days 1 and 14 in preoptic area than at day 60. Conversely, in cerebral cortex, receptor concentrations were significantly lower in neonatal animals than in 60-day-old animals. There was no change in affinity of the receptor during development. Castration has no apparent effect on α₁-receptor concentration in any brain area.

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Section: Experiments 1: Ontogeny Of Ai-receptor In the Male Guinea Pigmentioning

confidence: 99%

mentioning

confidence: 99%

Hypothalamic and Preoptic Area α1-Receptor Concentrations Decrease, and Cerebral Cortical α1-Receptor Concentrations Increase during Postnatal Maturation of Male Guinea Pigs

Johnson¹,

Nock²,

Ryer³

et al. 1984

Neuroendocrinology

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“…Another inhibitory effect of progesterone is the post-estrous refractoriness that occurs in intact guinea pigs after they have exhibited lordosis under the influence of their own hormonal secretion (Young, 1969).…”

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confidence: 99%

Effects of hysterectomy on sexual receptivity, food intake, running wheel activity, and hypothalamic estrogen and progestin receptors in rats.

Ahdieh¹,

Wade²

1982

Journal of Comparative and Physiological Psychology

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“…In addition, we anticipated mitigation of study variables due to territorial stress which likely had not begun to develop in what is defined as the pre-adolescent age of less than 40 days. 1,15,16 Currently our facility receives and holds male guineapigs for four days prior to release for study activity. The objective of this study was to determine whether the presence of a hut was an impact on physiological stress levels during this quarantine/acclimatization period.…”

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The impact of huts on physiological stress: a refinement in post-transport housing of male guineapigs (Cavia porcellus)

et al. 2012

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The ideal animal model would contribute no confounding variables in experimental science. Variables affect experimental design resulting in increased animal use or repeated studies. We demonstrated a simple refinement which may reduce the number of animals used experimentally while simultaneously improving animal welfare. The objective of this study was to determine if the presence of a hut was an impact on physiological stress levels, as determined by faecal cortisol concentration, during a routine four-day acclimatization period of newly received male Hartley-Outbred guineapigs. We hypothesized that those animals provided with huts would have decreased physiological stress compared with animals not provided with huts. We examined this effect within both paired and single-housed animals. A between-subjects one-way analysis of variance revealed that pair-housed animals with a hut had significantly lower faecal cortisol concentration than pair-housed animals without a hut and the presence and absence of a hut had no significant impact on faecal cortisol concentration in single-housed animals. These findings show that presence of a hut is beneficial in reducing physiological stress when pair housing male guineapigs and does not appear to have an impact when single housing male guineapigs. In addition, we have shown that faecal cortisol, and therefore physiological stress, is still increasing on study day 4 suggesting a longer acclimatization period is necessary. A simple refinement in housing environment and acclimatization time can both reduce the number of animals used experimentally and improve animal welfare. The guineapig has been used as a research model for decades.1 The physiological response of this species makes it an ideal animal model for multiple research applications such as anaphylaxis, delayed hypersensitivity and pharmacology, to name a few. In experimental design we minimize as many of these variables as possible by using, for example, controlled breeding practices, health surveillance and sentinel monitoring programmes. Another method of maintaining uniformity in our animal models is consistency in animal husbandry practices. One of these practices is the quarantine and stabilization 2 period provided to animals upon receipt into research facilities, the objective of which is to provide time for recovery from transport and identify animals which are unwell or less than ideal. Once complete it is commonly accepted, that unless grossly apparent otherwise, these animals are physiologically, behaviourally and nutritionally recovered from transport and therefore in model animal condition. Since we generally only employ observational signs of wellbeing such as water and food consumption, faeces and urine output along with physical appearance (i.e. posture, body condition, behaviour), we may be unaware of other subclinical factors that are still present. These unrecognized, and as such uncorrected, variables may result in profound consequences on research objectives 3 leading to repeated studie...

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Psychobiology of Sexual Behavior in the Guinea Pig

Cited by 92 publications

References 125 publications

Hypothalamic and Preoptic Area α<sub>1</sub>-Receptor Concentrations Decrease, and Cerebral Cortical α<sub>1</sub>-Receptor Concentrations Increase during Postnatal Maturation of Male Guinea Pigs

Hypothalamic and Preoptic Area α<sub>1</sub>-Receptor Concentrations Decrease, and Cerebral Cortical α<sub>1</sub>-Receptor Concentrations Increase during Postnatal Maturation of Male Guinea Pigs

Effects of hysterectomy on sexual receptivity, food intake, running wheel activity, and hypothalamic estrogen and progestin receptors in rats.

The impact of huts on physiological stress: a refinement in post-transport housing of male guineapigs (Cavia porcellus)

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