Psychoactive medications in chronic obstructive pulmonary disease patients: From prevalence to effects on motor command and strength

Cabibel, Vincent; Alexandre, François; Oliver, Nicolás; Varray, Alain; Héraud, Nelly

doi:10.1016/j.rmed.2019.105805

Cited by 4 publications

(3 citation statements)

References 64 publications

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“…Sleep disturbances are very common in COPD and, although it is not recommended in severe COPD, z-hypnotics are prescribed to COPD patients. 19 , 22 – 24 …”

Section: Discussionmentioning

confidence: 99%

“…However, when comparing results with benzodiazepine use -a regularly investigated drug group in COPD -multiple publications indicate a higher incidence of use, ranging from 20.9% to 69%. [8][9][10][19][20][21] This could partly be explained by the fact that in our study, only chronic users were selected to have a strong indication for the identification of depression and/or anxiety cases. In contrast, in other publications, the current use of ATDs and/or ANXs by patients using COPD medication was evaluated without accounting for the duration and frequency.…”

Section: Discussionmentioning

confidence: 99%

“…Sleep disturbances are very common in COPD and, although it is not recommended in severe COPD, z-hypnotics are prescribed to COPD patients. 19,[22][23][24] The relatively high rate of chronic ATD and/or ANX use in the patients suffering from dermatological problems, such as psoriasis and eczema, can be explained by the relationship between both skin and mental problems. 25 Women with depression had an increased risk of developing psoriasis.…”

Section: Discussionmentioning

confidence: 99%

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Higher prescription of antidepressants and/or anxiolytics among chronic obstructive pulmonary disease patients

Pelgrim

Heuvel

Folkerts

et al. 2021

Ther Adv Respir Dis

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Background: Chronic obstructive pulmonary disease (COPD) is often accompanied by psychiatric problems, such as depression and anxiety, affecting both treatment outcomes and mortality. Evidence for the number of COPD patients using medication for these disorders is sparse. In this study, chronic antidepressant (ATD) and anxiolytic (ANX) drug use – to identify depression and anxiety – among COPD patients was compared with subjects with or without other chronic diseases. Methods: The NControl database containing prescription data of 800 pharmacies including 7 million individuals in The Netherlands was used. Patients of age 55+ years who received frequent prescriptions – at least two/year in 5 out of 6 years – for COPD medication, dermatological drugs, disease-modifying antirheumatic drugs (DMARDs), statins and oral glucose-lowering medication were analyzed for concomitant chronic use of ATDs and ANXs between 1 January 2013 and 1 January 2019. All other subjects aged 55+ years were included as a control group (control group 1). This group was further stratified into a group of subjects that received frequent prescriptions of any kind (control group 2). Results: 15.2% of the patients that receive COPD treatment ( n = 96,319), 15.3% of subjects that are treated for dermatological problems ( n = 62,865), 13.2% of subjects that receive DMARDs ( n = 7900), 11.6% of statins users ( n = 422,376) and 11.4% of oral glucose-lowering medication users ( n = 165,975) are also chronically treated for depression or anxiety, compared with 2.6% (control group 1; n = 3,290,608) and 11.4% (control group 2; n = 757,947). In general, female and 75+ years aged subjects showed a higher risk for using ATDs and ANXs chronically. In the COPD and the dermatological patient group the risk was the highest compared with the other patient groups. Conclusions: The rates of chronic ATD and ANX use and the risk of having depression and/or anxiety are especially high in COPD patients, indicating that psychiatric problems are more common in COPD than in most other chronic diseases. In general, age and gender strongly influence the risk of chronically using ATDs and ANXs. The reviews of this paper are available via the supplemental material section.

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“…Sleep disturbances are very common in COPD and, although it is not recommended in severe COPD, z-hypnotics are prescribed to COPD patients. 19 , 22 – 24 …”

Section: Discussionmentioning

confidence: 99%