Psycho-Endocrine-Immune Response to Mindfulness-Based Stress Reduction in Individuals Infected with the Human Immunodeficiency Virus: A Quasiexperimental Study

Robinson, Fredie; Mathews, Herbert L.; Witek-Janusek, Linda

doi:10.1089/107555303322524535

Cited by 144 publications

(105 citation statements)

References 46 publications

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“…other MBSR studies (39,80). Attendance rates dropped during the first 4 sessions and then stabilized, consistent with other MBSR studies in which dropouts occurred early (81).…”

Section: Sephton Et Alsupporting

confidence: 87%

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Mindfulness meditation alleviates depressive symptoms in women with fibromyalgia: Results of a randomized clinical trial

Sephton¹,

Salmon²,

Weissbecker³

et al. 2007

Arthritis & Rheumatism

332

189

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Objective. Depressive symptoms are common among patients with fibromyalgia, and behavioral intervention has been recommended as a major treatment component for this illness. The objective of this study was to test the effects of the Mindfulness-Based Stress Reduction (MBSR) intervention on depressive symptoms in patients with fibromyalgia. Methods. This randomized controlled trial examined effects of the 8-week MBSR intervention on depressive symptoms in 91 women with fibromyalgia who were randomly assigned to treatment (n ‫؍‬ 51) or a waiting-list control group (n ‫؍‬ 40). Eligible patients were at least 18 years old, willing to participate in a weekly group, and able to provide physician verification of a fibromyalgia diagnosis. Of 166 eligible participants who responded to local television news publicizing, 49 did not appear for a scheduled intake, 24 enrolled but did not provide baseline data, and 2 were excluded due to severe mental illness, leaving 91 participants. The sample averaged 48 years of age and had 14.7 years of education. The typical participant was white, married, and employed. Patients randomly assigned to treatment received MBSR. Eight weekly 2.5-hour sessions were led by a licensed clinical psychologist with mindfulness training. Somatic and cognitive symptoms of depression were assessed using the Beck Depression Inventory administered at baseline, immediately postprogram, and at followup 2 months after the conclusion of the intervention. Results. Change in depressive symptoms was assessed using slopes analyses of intervention effects over time. Depressive symptoms improved significantly in treatment versus control participants over the 3 assessments. Conclusion. This meditation-based intervention alleviated depressive symptoms among patients with fibromyalgia.

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“…other MBSR studies (39,80). Attendance rates dropped during the first 4 sessions and then stabilized, consistent with other MBSR studies in which dropouts occurred early (81).…”

Section: Sephton Et Alsupporting

confidence: 87%

“…Analyses controlling for the effects of pain and sleep difficulties in the relationship between MBSR and depres- 80 …”

Section: Resultsmentioning

confidence: 99%

Mindfulness meditation alleviates depressive symptoms in women with fibromyalgia: Results of a randomized clinical trial

Sephton¹,

Salmon²,

Weissbecker³

et al. 2007

Arthritis & Rheumatism

332

189

View full text Add to dashboard Cite

show abstract

“…We also conducted a study in HIV+ men to evaluate the immune effects of MBSR. We found that MBSR normalized aspects of immune function that were dysregulated in these men (Robinson, et al, 2003). Others have also reported evidence of immune benefits of MBSR.…”

Section: Introductionsupporting

confidence: 67%

Effect of mindfulness based stress reduction on immune function, quality of life and coping in women newly diagnosed with early stage breast cancer

Witek-Janusek

Albuquerque

Chroniak

et al. 2008

Brain, Behavior, and Immunity

Self Cite

394

324

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This investigation used a non-randomized controlled design to evaluate the effect and feasibility of a mindfulness based stress reduction (MBSR) program on immune function, quality of life (QOL), and coping in women recently diagnosed with breast cancer. Early stage breast cancer patients, who did not receive chemotherapy, self-selected into an 8-week MBSR program or into an assessment only, control group. Outcomes were evaluated over time. The first assessment was at least 10 days after surgery and prior to adjuvant therapy, as well as before the MBSR start-up. Further assessments were mid-MBSR, at completion of MBSR, and at 4-weeks post MBSR completion. Women with breast cancer enrolled in the control group (Non-MBSR) were assessed at similar times. At the first assessment (i.e., before MBSR start), reductions in peripheral blood mononuclear cell NK cell activity (NKCA) and IFN gamma production with increases in IL-4, IL-6, and IL-10 production and plasma cortisol levels were observed for both the MBSR and Non-MBSR groups of breast cancer patients. Over time women in the MBSR group re-established their NKCA and cytokine production levels. In contrast, breast cancer patients in the Non-MBSR group exhibited continued reductions in NKCA and IFN gamma production with increased IL-4, IL-6, and IL-10 production. Moreover, women enrolled in the MBSR program had reduced cortisol levels, improved QOL, and increased coping effectiveness compared to the Non-MBSR group. In summary, MBSR is a program that is feasible for women recently diagnosed with early stage breast cancer and the results provide preliminary evidence of beneficial effects of MBSR on immune function, QOL, and coping effectiveness.

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“…In patients with breast cancer, MBSR increases activity in peripheral mononuclear cells, suggesting potential beneficial effects of MBSR on cell longevity in this setting. 8 In addition, use of MBSR has been associated with increased natural killer cell activity in patients with human immunodeficiency virus (although no significant clinical differences), 9 lower inflammatory responses, 9 increase in antibody titers to an influenza vaccine 10 and improvements in immune system function after strenuous physical stress.…”

Section: Physiologymentioning

confidence: 99%

Mindfulness-Based Stress Reduction and Transcendental Meditation: Current State of Research

Holt¹

2015

Journal of Patient-Centered Research and Reviews

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Psycho-Endocrine-Immune Response to Mindfulness-Based Stress Reduction in Individuals Infected with the Human Immunodeficiency Virus: A Quasiexperimental Study

Abstract: These results provide tentative evidence that MBSR may assist in improving immunity in individuals infected with HIV.

Cited by 144 publications

References 46 publications

Mindfulness meditation alleviates depressive symptoms in women with fibromyalgia: Results of a randomized clinical trial

Mindfulness meditation alleviates depressive symptoms in women with fibromyalgia: Results of a randomized clinical trial

Effect of mindfulness based stress reduction on immune function, quality of life and coping in women newly diagnosed with early stage breast cancer

Mindfulness-Based Stress Reduction and Transcendental Meditation: Current State of Research

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