Psychische Komorbidität bei Krebserkrankungen

Weis, Joachim; Boehncke, Anna

doi:10.1007/s00103-010-1184-y

Cited by 16 publications

(5 citation statements)

References 46 publications

(44 reference statements)

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“…Patients in the non-CRC group were more likely to show abnormal scores in any subscale of HADS, compatible with psychological morbidity. This is in agreement with a number of other studies showing that cancer types with poor prognosis such as lung, pancreatic, or head and neck cancers are associated with the highest rates of psychological distress [39,40]. As in several other trials, gender [9-12] as well as previous therapy experience [12] did not influence the anticipated survival thresholds.…”

Section: Discussionsupporting

confidence: 91%

Patients’ perspectives on palliative chemotherapy of colorectal and non - colorectal cancer: a prospective study in a chemotherapy- experienced population

et al. 2013

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BackgroundA better understanding of patients’ views on the benefit and burden obtained from palliative chemotherapy would facilitate shared decision making. We evaluated palliative cancer patients’ reported outcomes (PROs) for toxicity and investigated the survival threshold for which they would repeat chemotherapy (CTx).MethodsPatients who had received a minimum of three months of palliative CTx for advanced colorectal (CRC) or non-colorectal (non-CRC: upper gastrointestinal, lung and head-and-neck) cancer were assessed by questionnaire. Patients were questioned about PROs for toxicity, subjective burden from side effects, and were asked for the survival threshold necessary for them to repeat CTx. Expected survival (sum of indicated survival threshold and median survival time with best supportive care) was compared to the patients’ actual survival.ResultsOne hundred and thirty-four patients (CRC: 58; non-CRC: 76) were surveyed. The most frequent PRO- grade 3/4 toxicities were acne (12.8%), fatigue (9.0%), and diarrhea (8.5%). The symptom causing the highest subjective burden was fatigue and was worse than expected in 29.9% of the patients. The median survival threshold for which patients would repeat CTx was significantly longer in CRC than in non-CRC patients (p=0.01). Median expected survival was significantly longer than actual median survival (CRC: 44.0 months [22.0-65.9] compared with 30.0 months of actual survival [20.9-39.1]; non-CRC: 22.0 months [15.3-28.6] compared with 19.0 months of actual survival [15.1-22.9], p=0.03).ConclusionFatigue deserves more attention when toxicity of treatment and symptoms of disease are explained to patients. Patients’ survival expectations from palliative chemotherapy are higher than previously described, exceed the median survival time known from phase III trials, and are significantly longer than their actual survival.

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Section: Discussionsupporting

confidence: 91%

Patients’ perspectives on palliative chemotherapy of colorectal and non - colorectal cancer: a prospective study in a chemotherapy- experienced population

et al. 2013

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“…Weis et al fassen die sich daraus ableitenden Anforderungen an Screenings wie folgt zusammen: 4 schnell durchführbar, 4 verständlich für den Patienten, 4 praktikable und einfache Durchführung, 4 schnelle und einfache (automatisierte) Auswertung [24].…”

Section: Forschungskontext Und Fragestellungunclassified

“…Strittmacher et al haben bereits 2002 darauf aufmerksam gemacht, dass Screenings langfristige Risikofaktoren ebenso wie protektive Faktoren ermitteln soll-ten, um positive Ressourcen im Rahmen psychoonkologischer Interventionen gezielt zu stärken [22]. Zahlreiche Studien betonen darüber hinaus die Notwendigkeit, den Wunsch nach Unterstützung zu erfragen [2,24]. Dieser Aspekt kommt durch ergänzende Fragen in neueren Studien bereits zur Anwendung [6].…”

Section: Forschungskontext Und Fragestellungunclassified

Validierung des Düsseldorfer Screeningtools: ein traitbasierter Ansatz zur Erfassung der psychischen Belastung von Krebspatienten

Sisolefsky

Rana

et al. 2020

HNO

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Zusammenfassung Hintergrund Screening von psychischen Belastungen während einer Krebserkrankung ist notwendig, um gezielt die Patienten herauszufiltern, die psychologische Unterstützung benötigen. Derzeit geschieht dies überwiegend über die Abfrage akuter Probleme. Stabile interne und externe Risikofaktoren und präventiv wirkende Merkmale bleiben weitestgehend unberücksichtigt. Das neu entwickelte Düsseldorfer Screeningtool (DST) erfasst psychische Belastung mithilfe stabiler Traits, unter Berücksichtigung der sozialen Unterstützung und des Krankheitsverarbeitungsstils. Zielsetzung ist eine Validierung des DST anhand des Distress-Thermometers (DT) sowie der Psychoonkologischen Basisdokumentation (PO-Bado). Methodik Untersucht wurden 126 Patienten mit Plattenepithelkarzinomen im Bereich Hals und Kopf. Zur Festlegung des Cut-Off-Wertes wurden ROC Kurven (Receiver-Operating-Characteristics) berechnet. Als Maß für die Güte werden Area under Curve Werte (AUC) angegeben. Sensitivität und Spezifität wurden für den jeweils als Goldstandard genutzten Fragebogen festgelegt. Ergebnisse Die Diskriminationsfähigkeit des DST ist sowohl im Vergleich mit dem DT als auch mit der PO-Bado mit AUC-Werten von 0,62 bis 0,80 als gut zu bewerten. Bei einem Cut-Off-Wert des DT von 5 kann eine Sensitivität von 84,2 % bei gleichzeitiger Spezifität von 37,0 % angegeben werden. Im Vergleich zur PO-Bado kann ein Sensitivitätswert von 92,9 % bei gleichzeitiger Spezifität von 43,6 % angegeben werden. Schlussfolgerung Die Ergebnisse zeigen, dass auch ein traitbasierter Ansatz zur Erfassung von psychischer Belastung zielführend und sicher die Belastungssituation von Krebspatienten aufzeigen kann, sodass sich hier ein neuer Ansatz des Screenings in der Psychoonkologie herauskristallisiert hat.

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“…Furthermore, different instruments are used and some of them are not even specific for cancer pts. Especially in an outpatient setting, information about psychological distress and need for poi is unsatisfactory [8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Assessment and Evaluation of Psychosocial Distress in Outpatients with Cancer at a University Hospital in Germany

Hohmann¹,

Merx²,

Weingaertner³

et al. 2023

Oncol Res Treat

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Introduction: Cancer patients (pts) suffer from a significant amount of psychosocial distress related to tumor disease itself or straining treatments. Despite recommendations how to screen for and to deal with psychosocial distress in cancer pts, data about implementation of psycho-oncological interventions (poi) in outpatient settings of cancer pts is scarce. Aim of this study was to identify outpatients with cancer in need of poi and to evaluate different assessment instruments. Methods: N=200 outpatients with haemato-/oncological malignancies were interviewed between October 2015 and December 2017 at the University Hospital Mannheim using the Basic Documentation for Psycho-Oncology (PO-Bado) and the Hornheider Screening Instrument (HSI) – both clinician-administered assessment tools – followed by descriptive, univariate and agreement analysis. Results: N=61 cancer pts (31%) were identified to be in need for poi considering the results of both questionnaires. The number of identified patients in need of poi was lower when analyzing the results of the PO-Bado (n=42, 21%) and the HSI (n=39, 20%) separately. The degree of agreement the results of PO-Bado and HSI was low (kappa=0.3655). Several factors like gender, age and diagnosis were identified to have significant impact on the need for poi (p≤0.05). Discussion/Conclusion: Our study underlines, that different screening instruments for psychosocial distress may identify disparate populations of cancer pts. The study data also revealed significant characteristics that might be associated with elevated levels of psychosocial distress and a clear indication for poi. However, further analyses on larger populations of cancer pts are needed to provide information how to transfer positive screening to poi in clinical routine.

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Psychische Komorbidität bei Krebserkrankungen

Cited by 16 publications

References 46 publications

Patients’ perspectives on palliative chemotherapy of colorectal and non - colorectal cancer: a prospective study in a chemotherapy- experienced population

Patients’ perspectives on palliative chemotherapy of colorectal and non - colorectal cancer: a prospective study in a chemotherapy- experienced population

Validierung des Düsseldorfer Screeningtools: ein traitbasierter Ansatz zur Erfassung der psychischen Belastung von Krebspatienten

Assessment and Evaluation of Psychosocial Distress in Outpatients with Cancer at a University Hospital in Germany

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