Psychic Disturbances in Adult Coeliac Disease

Hallert, Claes; Derefeldt, T.

doi:10.3109/00365528209181037

Cited by 100 publications

(29 citation statements)

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“…In this context, another finding of our study is the evidence of a degree of depressive and anxiety symptoms in CD patients, adding further support to the relationship between psychiatric disorders and CD [45], [46]. Major depression has been widely studied by TMS, which has confirmed the key role of the GABAergic dysfunction in the neurochemical pattern of depressed mood, as indexed by a reduction of both CSP and ICI [11], [47]-[50].…”

Section: Discussionsupporting

confidence: 77%

Excitability of the Motor Cortex in De Novo Patients with Celiac Disease

et al. 2014

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IntroductionCeliac disease (CD) may initially present as a neurological disorder or may be complicated by neurological changes. To date, neurophysiological studies aiming to an objective evaluation of the potential central nervous system involvement in CD are lacking.ObjectiveTo assess the profile of cortical excitability to Transcranial Magnetic Stimulation (TMS) in a group of de novo CD patients.Materials and methodsTwenty CD patients underwent a screening for cognitive and neuropsychiatric symptoms by means of the Mini Mental State Examination and the Structured Clinical Interview for DSM-IV Axis I Disorders, respectively. Instrumental exams, including electroencephalography and brain computed tomography, were also performed. Cortico-spinal excitability was assessed by means of single and paired-pulse TMS using the first dorsal interosseus muscle of the dominant hand. TMS measures consisted of resting motor threshold, motor evoked potentials, cortical silent period (CSP), intracortical inhibition (ICI) and facilitation (ICF). None of the CD was on gluten-free diet. A group of 20 age-matched healthy controls was used for comparisons.ResultsCD showed a significantly shorter CSP (78.0 vs 125.0 ms, p<0.025), a reduced ICI (0.3 vs 0.2, p<0.045) and an enhanced ICF (1.1 vs 0.7, p<0.042) compared to controls. A dysthymic disorder was identified in five patients. The effect size between dysthymic and non-dysthymic CD patients indicated a low probability of interference with the CSP (Cohen's d -0.414), ICI (-0.278) and ICF (-0.292) measurements.ConclusionA pattern of cortical excitability characterized by “disinhibition” and “hyperfacilitation” was found in CD patients. Immune system dysregulation might play a central role in triggering changes of the motor cortex excitability.

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Section: Discussionsupporting

confidence: 77%

Excitability of the Motor Cortex in De Novo Patients with Celiac Disease

et al. 2014

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“…State anxiety was present in a higher percentage of CD patients with respect to controls, while trait anxiety was not significantly different between CD patients and healthy controls, indicating that anxiety could be related to the disabling symptoms present at the time of the clinical and psychometric observation and to a sense of being different with respect to healthy subjects [10] . In addition, CD patients compared to controls showed higher scores of depression scale, supporting the previous findings [6][7][8][9] .…”

supporting

confidence: 80%

Affective and Psychiatric Disorders in Celiac Disease

Addolorato

Leggio

D’Angelo

et al. 2008

Dig Dis

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Several extraintestinal clinical manifestations have been reported in celiac disease (CD). Among them, growing evidence suggests the association between CD and affective and psychiatric disorders. In this review the most frequent affective and psychiatric disorders associated with CD and the possible mechanisms involved in these associations were analyzed. The available data suggest that screening for CD in patients with affective and/or psychiatric symptoms may be useful since these disorders could be the expression of an organic disease rather than primary psychiatric illnesses.

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“…Hans Asperger reported that children with celiac disease also often exhibit psychological problems (Asperger 1961). Anxiety, depression, epilepsy, severe progressive neuropathy, gait ataxia, and limb ataxia are also seen in adult patients with celiac disease (Hallert and Derefeldt 1982, Hadjivassiliou et al 2002, Bushara 2005, Fasano and Catassi 2005, Genuis and Bouchard 2010). In individuals with diseases/syndromes such as irritable bowel syndrome (IBS), ulcerative colitis and Crohn’s disease, psychiatric symptoms have also been reported (Ringel and Drossman 2001, Ringel and Drossman 2002).…”

Section: Introductionmentioning

confidence: 99%