Psychiatrie Outcomes in Low-Birth-Weight Children at Age 6 Years: Relation to Neonatal Cranial Ultrasound Abnormalities

Whitaker, Agnes H.; Rossem, Ronan Van; Feldman, Judith F.; Schonfeld, Irvin Sam; Pinto‐Martin, Jennifer; Torre, Carolyn; Shaffer, David; Paneth, Nigel

doi:10.1001/archpsyc.1997.01830210091012

Cited by 265 publications

(144 citation statements)

References 73 publications

Supporting

Mentioning

130

Contrasting

Unclassified

Order By: Relevance

“…Between 5 and 15% of prematurely born children develop cerebral palsy, and 30 to 50% will have impaired academic achievement and/or behavioral disorders requiring additional educational resources (Hack and Fanaroff, 1999;Hack et al, 2002;Saigal et al, 1991;Whitaker et al, 1997;Whitfield et al, 1997). The nature of the cerebral lesion predisposing the prematurely born child to such long-term neurodevelopmental difficulties is not well understood, as the association between abnormalities detected on conventional MRI studies and cognitive neurodevelopmental outcome is relatively weak (Cooke and Abernethy, 1999).…”

Section: Introductionmentioning

confidence: 99%

Diffusion MR imaging characteristics of the developing primate brain

et al. 2005

View full text Add to dashboard Cite

Diffusion-based magnetic resonance imaging holds the potential to noninvasively demonstrate cellular-scale structural properties of brain. This method was applied to fixed baboon brains ranging from 90 to 185 days gestational age to characterize the changes in diffusion properties associated with brain development. Within each image voxel, a probability-theory-based approach was employed to choose, from a group of analytic equations, the one that best expressed water displacements. The resulting expressions contain eight or fewer adjustable parameters, indicating that relatively simple expressions are sufficient to obtain a complete description of the diffusion MRI signal in developing brain. The measured diffusion parameters changed systematically with gestational age, reflecting the rich underlying microstructural changes that take place during this developmental period. These changes closely parallel those of live, developing human brain. The information obtained from this primate model of cerebral microstructure is directly applicable to studies of human development. D 2004 Elsevier Inc. All rights reserved.Keywords: Magnetic resonance imaging; Diffusion anisotropy; Baboon brains; Brain development IntroductionMagnetic resonance imaging (MRI) is increasingly utilized in human and animal studies to provide information relating to cerebral injury and development in the newborn. Diffusion MRI, in particular, is being applied to assess brain development (Huppi et al., 1998;Neil et al., 2002;Partridge et al., 2004;Rutherford et al., 2004). Diffusion MRI provides information about the directional dependence of water displacements due to diffusion. This, in turn, reflects underlying tissue microstructure. In white matter, for example, water moving parallel to myelinated fibers can move within or between myelin layers, without crossing membranes. Water moving orthogonal to fibers, on the other hand, must either cross myelin layers or go around them. As a result, water displacements are smaller when measured orthogonal to myelinated fibers than when measured parallel to them. Thus, water diffusion in myelinated white matter is anisotropic. The regional changes in diffusion anisotropy within the developing white matter of the newborn brain have been well appreciated for some time (Huppi et al., 1998;Neil et al., 1998).Diffusion anisotropy has also been described within cerebral cortical gray matter in the developing human brain. Anisotropy is high early in development, with the preferred displacement direction oriented radially with respect to the cortical surface (Maas et al., 2004;Mori et al., 2001;Neil et al., 1998). This has been attributed to the orientation of radial glial fibers and the apical dendrites of pyramidal cells. As the brain matures, the magnitude of cortical diffusion anisotropy decreases (McKinstry et al., 2002;Mori et al., 2001), reflecting a loss in orientational coherence of cortical structures that restrict diffusion. This may be due to the elaboration of pyramidal cell basal dendrites, additio...

show abstract

Section: Introductionmentioning

confidence: 99%

Diffusion MR imaging characteristics of the developing primate brain

et al. 2005

View full text Add to dashboard Cite

show abstract

“…10 This white matter is situated below the cortex and contains the myelinated axons of nerve processes. 11 These nerve processes can be classified into three groups; association fibres which interconnect cortical sites within one cerebral hemisphere; commissural fibres which connect functionally related structures between the two hemispheres; and projection fibres which pass between the cerebral cortex and subcortical structures such as the thalamus, striatum, brain stem and spinal cord.…”

Section: Low Birth Weight -A Predictor For Psychiatric Problems?mentioning

confidence: 99%

“…Whitaker and colleagues discovered that infants with parenchymal lesions and ventricular enlargement, processes indicative of white matter ischaemic insult, are those who go onto suffer psychiatric sequelae. 10 Following 32 weeks gestation the arterial supply of this region increases and hence it is at less risk from hypoperfusion. Therefore, it is only premature infants who usually suffer these complications with subcortical white matter injury.…”

Section: Low Birth Weight -A Predictor For Psychiatric Problems?mentioning

confidence: 99%

“…10 It is also argued that cortical grey matter may also be affected by white matter injury due to late migration, organisation, and myelination in the development process. 10 Hence, it may not be affected white matter which causes psychiatric disturbances in the child and adolescent, but rather other regions which have been affected by white matter lesions after cranial ultrasonography was performed.…”

Section: Low Birth Weight -A Predictor For Psychiatric Problems?mentioning

confidence: 99%

See 1 more Smart Citation

Low birth weight – a predictor for psychiatric problems?

Harris

2001

Ir. j. psychol. med.

View full text Add to dashboard Cite

“…Prematurity -particularly when combined with a birth-weight below 2000 gs and subsequent periventricular brain lesions -is a strong predictor of later neuropsychiatric disorder (Whitaker et al 1997). Retinopathy of prematurity (ROP) was a common sequel of prematurity up until the early 1990s, often leading to blindness and causing severe impairment in many cases.…”

Section: Prematurity Associated With Retinopathymentioning

confidence: 99%

Ahrnberg‐Symposium

1998

Acta Ophthalmologica Scandinavica

View full text Add to dashboard Cite

Psychiatrie Outcomes in Low-Birth-Weight Children at Age 6 Years: Relation to Neonatal Cranial Ultrasound Abnormalities

Abstract: Neonatal cranial ultrasound abnormalities suggestive of white matter injury significantly increased risk for some psychiatric disorders at age 6 years in low-birth-weight children.

Cited by 265 publications

References 73 publications

Diffusion MR imaging characteristics of the developing primate brain

Diffusion MR imaging characteristics of the developing primate brain

Low birth weight – a predictor for psychiatric problems?

Ahrnberg‐Symposium

Contact Info

Product

Resources

About