Psychiatric syndromes in Parkinson's disease

Starkstein, Sergio E.; Brockman, Simone; Hayhow, Brad

doi:10.1097/yco.0b013e3283577ed1

Cited by 59 publications

(39 citation statements)

References 29 publications

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“…Stemming from a progressive loss of dopaminergic neurons in the substantia nigra, motor symptoms mainly encompass bradykinesia, rigidity, and tremor (Damier, Hirsch, Agid, & Graybiel, 1999). Frequent additional nonmotor symptoms include depression, anxiety, apathy, (hypo‐)mania, dementia, psychosis, and impulse control disorder (Callesen, Weintraub, Damholdt, & Moller, 2014; van der Hoek et al., 2011; Maier et al., 2014; Reijnders, Ehrt, Weber, Aarsland, & Leentjens, 2008; Richard, 2007; Riedel et al., 2008; Sagna, Gallo, & Pontone, 2014; Starkstein, Brockman, & Hayhow, 2012). Together with motor symptoms (Appleman, Stavitsky, & Cronin‐Golomb, 2011; Hechtner et al., 2014; Weintraub et al., 2010), nonmotor symptoms can severely affect patients′ health‐related quality of life (Montel, Bonnet, & Bungener, 2009; Shearer, Green, Counsell, & Zajicek, 2012; for reviews see Den Oudsten, Van Heck, & De Vries, 2007; van Uem et al., 2016).…”

Section: Introductionmentioning

confidence: 99%

Relationships between activity and well‐being in people with parkinson's disease

et al. 2018

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ObjectivesThe complex symptomatology of Parkinson’ disease (PD) usually goes along with reduced physical activity. Previous studies have indicated positive effects of activating therapies on patients’ well‐being. This study, therefore, examined how activity in daily life is related to patients’ subjective condition.Materials and MethodsTwenty‐one PD patients rated their condition every two hours during two routine days and documented the duration and type of their activities (based on the PRISCUS‐Physical Activity Questionnaire) during the respective time intervals. They were furthermore assessed regarding motor and nonmotor symptoms, personality factors, and coping strategies.ResultsPatients spent on average 8.59 ± 2.93 hr per day at physical rest and 5.47 ± 2.93 hr physically active. We found highly significant associations between positive condition ratings (such as happiness, motivation, and concentration) and the duration of subsequent physical activities (adj.r 2 = .689) as well as between the duration of these activities and a subsequent improvement in the subjective condition (adj.r 2 = .545). This was strongest in patients using active coping strategies and showing agreeable and conscientious personality traits (adj.r 2 = .380). Nonmotor symptom severity was weakly inversely related to the daily amount of activities (adj.r 2 = .273), whereas no significant association with motor symptom severity was found.ConclusionsThe results suggest a feedback process between a positive subjective condition and physical activities in PD patients. This appears to depend on the use of active coping strategies and nonmotor symptoms rather than on motor symptom severity. The results should encourage physicians to address the importance of everyday physical activities and to provide patients with behavioral advice.

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Section: Introductionmentioning

confidence: 99%

Relationships between activity and well‐being in people with parkinson's disease

et al. 2018

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“…Literatürde PH'na eşlik eden depresif bozukluk tedavisinde trisiklik antidepresanlar, selektif serotonin geri alım inhibitörleri ve psikoterapinin etkin olduğu belirtilmektedir 8 .…”

Section: Introductionunclassified

Depresyon ve Parkinson Hastalığı Birlikteliği olan Bir Hastada Elektrokonvülsif Tedavi

Topbaş¹,

Eroğlu²,

Zabun³

et al. 2014

Cukurova Medical Journal

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ÖZETParkinson Hastalığı temel olarak bir hareket bozukluğu olmakla birlikte, sıklıkla affektif, bilişsel ve psikotik bozuklukların eşlik etmesi nedeniyle bir nöropsikiyatrik hastalık olarak tanımlanmaktadır. Depresyonun da Parkinson hastalığında en sık görülen psikiyatrik rahatsızlık olduğu bilinmektedir. Parkinson hastalığındaki depresyonun tedavisine yönelik farklı yaklaşımlar bulunmaktadır. Antidepresanlar ve bilişsel davranışçı terapi kullanılmakla birlikte, yaşlı hasta grubunda özkıyım riski, fiziksel durumun bozulması, psikomotor retardasyon ve ilaca yetersiz yanıt alındığında elektrokonvülsif tedavi tercih edilebilir. Bu yazıda yaşlı bir hastada Parkinson hastalığı sırasında ortaya çıkan bir depresyon atağının elektrokonvülsif tedavisi sunulmuştur. Anahtar Kelimeler: Depresyon, parkinson hastalığı, elektrokonvülsif tedavi, yaşlı. ABSTRACTParkinson's disease can be defined as a neuropsychiatric disease which is basicly a dismotilite disease, often with affective cognitive and psychotic disorder. Depression is the most frequent psychiatric disorder in patients with Parkinson's disease.There are several possible approaches for the treatment of depression in Parkinson disease. We can use antidepresants and conitive behavioral therapy, and can be prefer to use electroconvulsive therapy in the condition that, the suicidal risk of elder patient groups, disorder of the phsical condition, psychomotor retardation and insufficient response to the medicine.ın this article, an electroconvulsive therapy treatment is reported, which is about a depression attact in an elderly patient who has Parkinson's disease.

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“…Several studies have also shown that individuals with depression are 2.2 to 3.2 times more likely to develop PD compared to healthy controls 43 . Although the available data regarding this correlation are less conclusive than for hyposmia and RBD, the onset of depressive symptoms may precede the motor signs, with a peak around 3-6 years before the diagnosis of PD.…”

Section: Behavioral Disordersmentioning

confidence: 99%

“…Non-motor signs: prevalence, respective level of functional disability and potential role as premotor signs of Parkinson's disease 15,16,17,18,19,35,43,44,45,47,48,49,51,52,53,60 . healthy elderly individuals, those with proven olfactory deficit had a higher risk of developing symptomatic PD clinical and when they remained asymptomatic, these individuals presented LB in the SNc on post-mortem examination.…”

Section: Olfactory Deficitmentioning

confidence: 99%

Non-motor signs in Parkinson’s disease: a review

Munhoz

Moro

Silveira‐Moriyama

et al. 2015

Arq. Neuro-Psiquiatr.

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The traditional pathological description of PD as a pre-synaptic degenerative process affecting dopaminergic neurons in the substantia nigra pars compacta (SNc) of the midbrain with formation of Lewy bodies (LB) has changed dramatically in the last decade since functional and neuropathological studies showed the occurrence of extensive extranigral involvement 1 . Among these investigations, the seminal study of Braak et al. 2 suggested that the degenerative process in the PD starts in the caudal regions of the brainstem and the olfactory bulb, progressing in the caudal-rostral direction. The involvement of the SNc occurs, according to this hypothesis, on the third of a six-stage process that begins in the dorsal motor nuclei of the glossopharyngeal and vagus nerves and the olfactory bulb. Although it demonstrates the occurrence of this peculiar pathological distribution, the study fails to make the clinical correlation between any of these changes and motor or non-motor manifestations. On the other hand, even considering this caveat, it was one of the studies that formed the basis and motivated the dissemination of the concept of the existence of non-motor signs (NMS), especially dysautonomia, olfaction and sleep disorders, as part of the disease, sometimes even preceding the classic motor symptoms of PD.The motor aspects of PD typically have a slow progression and direct correlation with the presence of neuronal degeneration in the SNc, but they do not represent the actual beginning of the degenerative process. This process is, in fact, in full progression, despite been apparently silent when one seeks only for motor signs 3 . EXTRANIGRAL DEGENERATIONThe notion of PD as a multisystemic disease, not restricted to the nigrostriatal tract is not new, however the cited ABSTRACTDuring the past decade the view of Parkinson's disease (PD) as a motor disorder has changed significantly and currently it is recognized as a multisystem process with diverse non-motor signs (NMS). In addition to been extremely common, these NMS play a major role in undermining functionality and quality of life. On the other hand, NMS are under recognized by physicians and neglected by patients. Here, we review the most common NMS in PD, including cognitive, psychiatric, sleep, metabolic, and sensory disturbances, discuss the current knowledge from biological, epidemiological, clinical, and prognostic standpoints, highlighting the need for early recognition and management.Keywords: Parkinson's disease, non-motor signs, dementia, hyposmia, psychosis. RESUMONo decorrer da última década, a visão da doença de Parkinson (DP) como um distúrbio de movimento puro mudou significativamente, sendo atualmente reconhecida como um processo multisistêmico com diversos sinais não motores (SNM). Além de serem extremamente comuns, estes SNM têm um impacto muito significativo na limitacão funcional e da qualidade de vida na DP. Por outro lado, os SNM são mal reconhecidos pelos clínicos e negligenciados pelos pacientes. Nessa revisão os SNM mais comuns na DP fo...

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Psychiatric syndromes in Parkinson's disease

Cited by 59 publications

References 29 publications

Relationships between activity and well‐being in people with parkinson's disease

Relationships between activity and well‐being in people with parkinson's disease

Depresyon ve Parkinson Hastalığı Birlikteliği olan Bir Hastada Elektrokonvülsif Tedavi

Non-motor signs in Parkinson’s disease: a review

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