Psychiatric symptoms subsequent to COVID-19 and their association with clinical features: A retrospective investigation

Fiabane, Elena; Pain, Debora; Aiello, Edoardo Nicolò; Radici, Alice; Manera, Marina; Grossi, Federica; Ottonello, Marcella; Pistarini, Caterina

doi:10.1016/j.psychres.2022.114757

Cited by 6 publications

(5 citation statements)

References 18 publications

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“…Several studies have provided evidence for the COVID-19 related mental distress among individuals [ 4 , 5 ]. Definitely, posttraumatic stress disorder (PTSD) and depression were two kinds of common mental distress [ 6 ].Relevant studies have shown a high incidence of depression in patients, as well as among frontline health workers [ 7 , 8 ]. Furthermore, in the systematic meta-analysis of 15,538 individuals affected by the public health emergencies (PHEs), the estimated prevalence (17%) of post-traumatic stress syndromes during the last two decades indicated that post-traumatic stress symptoms frequently occur as a result of PHEs.…”

Section: Introductionmentioning

confidence: 99%

The impact of isolation on comorbidity of PTSD symptoms and depression: evidence from PTRP-5-6 in China

Yan,

Shang,

et al. 2024

BMC Public Health

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Background The Omicron pandemic struck Shanghai, China, resulting in impairments of both physical and psychological health on those patients who were confirmed and transferred to the Fangcang shelters. The way of isolation led to high risk of posttraumatic stress symptoms (PTSS) and depressive symptoms among the patients in Fangcang shelters. We aim to estimate the prevalence and comorbidity of PTSS and depressive symptoms in patients from China’s Fangcang shelters during the epidemic. Methods Demographic information questionnaire, the posttraumatic stress disorder checklist for DSM-5 (PCL-5), and Patient Health Questionnaire (PHQ-9) were used in the study. The data were collected online via mobile phones during 10th April to 20th April, 2022, as part of our Psychological Trauma Recover Project-5-6 (PTRP-5-6), a longitudinal study focusing on individuals who have experienced trauma. Results A total of 336 subjects were included in the analysis. The results revealed (1) the prevalence of depressive symptoms, and PTSS were 30.1% (cut-off = 10) and 6% (cut-off = 33); (2) Multiple logistic regression showed that female (OR = 3.04, p < 0.05), suffering from dyspnea (OR = 5.83, p < 0.05) or gastrointestinal symptoms (OR = 6.38, p < 0.05) were risk factors for PTSS; higher education level (OR = 3.27, p < 0.05) and suffering from dizziness or headache (OR = 2.46, p < 0.05) were risk factors for depressive symptoms; (3)Respectively, 85% of the patients who reported PTSS also experienced depressive symptoms, 16.8% of the patients who reported depressive symptoms presented PTSS. Conclusion In the context of COVID-19, the comorbidity rate of PTSS and depressive symptoms among patients in Fangcang shelters increased with the severity of depressive symptoms.

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Section: Introductionmentioning

confidence: 99%

The impact of isolation on comorbidity of PTSD symptoms and depression: evidence from PTRP-5-6 in China

Yan,

Shang,

et al. 2024

BMC Public Health

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“… 25 The neurological sequelae of COVID-19 are associated with increased mental stress and the risks for mental disorders. 14 , 26–29 …”

Section: Introductionmentioning

confidence: 99%

Causal associations and genetic overlap between COVID-19 and intelligence

Cao

Baranova

Song

et al. 2023

QJM: An International Journal of Medicine

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Objective COVID-19 might cause neuroinflammation in the brain, which could decrease neurocognitive function. We aimed to evaluate the causal associations and genetic overlap between COVID-19 and intelligence. Methods We performed Mendelian randomization (MR) analyses to assess potential associations between three COVID-19 outcomes and intelligence (N = 269,867). The COVID phenotypes included SARS-CoV-2 infection (N = 2,501,486), hospitalized COVID-19 (N = 1,965,329), and critical COVID-19 (N = 743,167). Genome-wide risk genes were compared between the genome-wide association study (GWAS) datasets on hospitalized COVID-19 and intelligence. In addition, functional pathways were constructed to explore molecular connections between COVID-19 and intelligence. Results The MR analyses indicated that genetic liabilities to SARS-CoV-2 infection (OR: 0.965, 95% CI: 0.939-0.993) and critical COVID-19 (OR: 0.989, 95% CI: 0.979-0.999) confer causal effects on intelligence. There was suggestive evidence supporting the causal effect of hospitalized COVID-19 on intelligence (OR: 0.988, 95% CI: 0.972-1.003). Hospitalized COVID-19 and intelligence share ten risk genes within two genomic loci, including MAPT and WNT3. Enrichment analysis showed that these genes are functionally connected within distinct subnetworks of 30 phenotypes linked to cognitive decline. The functional pathway revealed that COVID-19-driven pathological changes within the brain and multiple peripheral systems may lead to cognitive impairment. Conclusions Our study suggests that COVID-19 may exert a detrimental effect on intelligence. The tau protein and Wnt signaling may mediate the influence of COVID-19 on intelligence.

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“…These postrecovery symptoms are called 'long COVID-19 syndrome' and commonly include depression, anxiety and cognitive impairment. [9][10][11][12][13][14] These psychopathological sequelae of COVID-19 are both from an improper immune response to the virus and neuroinflammation caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and augmented by diseaserelated psychological stressors. 15 16 Major depressive disorder (MDD) is a common mood disorder that causes persistent sadness and loss of interest.…”

Section: Introductionmentioning

confidence: 99%

“…After the acute phase of COVID-19, some patients develop lingering symptoms, such as pulmonary dysfunction, muscle exertion and mood changes that persist for months. These postrecovery symptoms are called ‘long COVID-19 syndrome’ and commonly include depression, anxiety and cognitive impairment 9–14. These psychopathological sequelae of COVID-19 are both from an improper immune response to the virus and neuroinflammation caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and augmented by disease-related psychological stressors 15 16…”

Section: Introductionmentioning

confidence: 99%

Causal associations between major depressive disorder and COVID-19

et al. 2023

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BackgroundWe aimed to evaluate whether major depressive disorder (MDD) could aggravate the outcomes of coronavirus disease 2019 (COVID-19) or whether the genetic liability to COVID-19 could trigger MDD.AimsWe aimed to assess bidirectional causal associations between MDD and COVID-19.MethodsWe performed genetic correlation and Mendelian randomisation (MR) analyses to assess potential associations between MDD and three COVID-19 outcomes. Literature-based network analysis was conducted to construct molecular pathways connecting MDD and COVID-19.ResultsWe found that MDD has positive genetic correlations with COVID-19 outcomes (rg: 0.10–0.15). Our MR analysis indicated that genetic liability to MDD is associated with increased risks of COVID-19 infection (odds ratio (OR)=1.05, 95% confidence interval (CI): 1.00 to 1.10, p=0.039). However, genetic liability to the three COVID-19 outcomes did not confer any causal effects on MDD. Pathway analysis identified a panel of immunity-related genes that may mediate the links between MDD and COVID-19.ConclusionsOur study suggests that MDD may increase the susceptibility to COVID-19. Our findings emphasise the need to increase social support and improve mental health intervention networks for people with mood disorders during the pandemic.

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Psychiatric symptoms subsequent to COVID-19 and their association with clinical features: A retrospective investigation

Cited by 6 publications

References 18 publications

The impact of isolation on comorbidity of PTSD symptoms and depression: evidence from PTRP-5-6 in China

The impact of isolation on comorbidity of PTSD symptoms and depression: evidence from PTRP-5-6 in China

Causal associations and genetic overlap between COVID-19 and intelligence

Causal associations between major depressive disorder and COVID-19

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