Psychiatric symptoms in ruptured anterior communicating aneurysms: social prognosis

Okawa, Masako; Maeda, Shoichi; Nukui, Hideaki; Kawafuchi, Jun‐ichi

doi:10.1111/j.1600-0447.1980.tb00583.x

Cited by 37 publications

(9 citation statements)

References 5 publications

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“…Treatment options to improve the cognitive impairments following aneurysm rupture are strongly needed. In patients with the so‐called ACoA syndrome, cognitive or psychiatric residuals are frequently found, often with a pervasive negative impact on the patient's life (Okawa et al. , 1980; Stenhouse et al.…”

Section: Discussionmentioning

confidence: 99%

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Cholinergic treatment of amnesia following basal forebrain lesion due to aneurysm rupture – an open‐label pilot study

Benke¹,

Köylü²,

Delazer³

et al. 2005

Euro J of Neurology

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Impairments of memory are often found after rupture and repair of aneurysms leading to a basal forebrain lesion. This open study investigated whether cholinergic substitution therapy may be a treatment option. The effect of donepezil, a cholinesterase inhibitor on memory functions was tested in an open-label, exploratory study in 11 patients with a chronic amnestic syndrome from a ruptured and repaired aneurysm of the anterior communicating artery (seven patients), the anterior cerebral (two) or the pericallosal artery (two). Mean time since onset was 75.4 months. Memory was evaluated at baseline and consecutively after 4 weeks of 5 mg donepezil daily, 8 weeks of 10 mg donepezil, and 4 weeks after drug discontinuation. Memory functions were assessed using the California Verbal Learning Test and compared with a matched group of normal, untreated controls. Tests of attention and of executive functions were also administered. Donepezil was well tolerated. Strong group effects were found at baseline and at all follow-up measurements showing profound impairments of memory functions in the patient group. Within patient statistics showed significant improvements of short and long delay free recall scores during the treatment period, both with 5 and 10 mg donepezil daily, whereas attentional and executive functions improved only non-significantly. Memory functions decreased after drug discontinuation. Repeated test administration in the control group also showed an increase of memory scores which was minor when compared with the performance change in the patient group. Donepezil may improve episodic memory functions in patients suffering from a chronic amnestic syndrome caused by rupture and repair of aneurysms of the anterior communicating, the anterior cerebral or the pericallosal artery. Future doubled-blind, placebo-controlled trials are warranted to confirm these findings.

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Section: Discussionmentioning

confidence: 99%

“…, 2002). Depending on the patient characteristics and the neuropsychological tests and criteria used, 40–70% of this patient group is estimated to retain severe cognitive deficits (Okawa et al. , 1980; Stenhouse et al.…”

Section: Introductionmentioning

confidence: 99%

Cholinergic treatment of amnesia following basal forebrain lesion due to aneurysm rupture – an open‐label pilot study

Benke¹,

Köylü²,

Delazer³

et al. 2005

Euro J of Neurology

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“…On the contrary, other studies could not find any relationship between side of aneurysm and postoperative performance (De Santis et al 1989, Maurice-Williams et al 1991, Tidswell et al 1995. Anterior communicating artery (AcoA) aneurysmal SAH has been found, in several studies, to be associated with changes in personality, intellectual function, memory and conceptual learning, and with poor social adjustment (Sengupta et al 1975, Okawa et al 1980, Stenhouse et al 1991. In contrast to these findings, Hü tter et al (1995) found no statistically significant differences between AcoA patients and patients with other aneurysm locations.…”

Section: Outcomementioning

confidence: 97%

“…Anterior communicating artery (AcoA) aneurysmal SAH has been found, in several studies, to be associated with changes in personality, intellectual function, memory and conceptual learning, and with poor social adjustment (Sengupta et al. 1975, Okawa et al. 1980, Stenhouse et al.…”

Section: Outcomementioning

confidence: 99%

Patient information after ruptured intracranial aneurysm

Vogelsang

Wengström²,

Forsberg³

2004

Journal of Advanced Nursing

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“…Some studies reported little or no persisting significant neuropsychological deficits in uncomplicated SAH 2-4 while others indicated that deficits do occur and are caused by global [5][6][7][8][9][10][11][12][13][14] or focal brain damage. 10,[15][16][17] These varieties in the study results may be caused by differences in the clinical state of the patients immediately following the ictus, i.e., the strength of the bleeding besides the possibility of aneurysm site playing a role in the outcome of SAH. The effect of aneurysm location on outcome is not fully explored.…”

Section: Introductionmentioning

confidence: 88%

Cognitive functioning and health related quality of life after rupture of an aneurysm on the anterior communicating artery versus middle cerebral artery

Haug

Sorteberg

et al. 2009

British Journal of Neurosurgery

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The neuropsychological outcome and Health Related Quality of Life (HRQOL) after SAH have been largely believed to be unrelated to the location of the ruptured aneurysm. This notion needs verification due to the contemporary availability of more sensitive neuropsychological test batteries and more recent clinical observations of deviant behaviour after SAH. To this end, we compared patients with ruptured aneurysms on respectively the anterior communicating artery (ACoA) (n = 24) or middle cerebral artery (MCA) (n = 22). All patients underwent an extensive neuropsychological examination, clinical interview and answered questionnaires 12 months after SAH. We found mild to moderate discrepancies from population norm in test scores on a number of areas of cognitive functioning in both patient groups, with a consistent, but statistically non-significant trend towards better functioning in MCA patients despite of the fact that patients with ruptured MCA aneurysms were initially in a poorer clinical condition and more often had intracranial haematomas. We observed slight reductions in executive functions, on the first conditions on the Delis-Kaplan Executive Functioning System (D-KEFS) tests, and some measures of memory functions in the ACoA patients. ACoA patients seemed to have problems with initiation of problem solving behaviour. None of the patient groups scored for apathy and depression. Some measures of HRQOL were equally reduced as compared to the population norm in both groups. ACoA patients remained longer on sick-leave compared to MCA patients.

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Psychiatric symptoms in ruptured anterior communicating aneurysms: social prognosis

Cited by 37 publications

References 5 publications

Cholinergic treatment of amnesia following basal forebrain lesion due to aneurysm rupture – an open‐label pilot study

Cholinergic treatment of amnesia following basal forebrain lesion due to aneurysm rupture – an open‐label pilot study

Patient information after ruptured intracranial aneurysm

Cognitive functioning and health related quality of life after rupture of an aneurysm on the anterior communicating artery versus middle cerebral artery

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