Psychiatric symptoms in ankylosing spondylitis: their relationship with disease activity, functional capacity, pain and fatigue

Durmuş, Dilek; Sarısoy, Gökhan; Alaylı, Gamze; Kesmen, Hakan; Çetin, Eda; Bilgici, Ayhan; Kuru, Ömer; Ünal, Mustafa

doi:10.1016/j.comppsych.2015.07.016

Cited by 35 publications

(22 citation statements)

References 32 publications

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“…These relationships to disease activity measures and a prevalence of FMS as high as 30% were largely confirmed by other studies [47][48][49] The relatively high prevalence of FMS is not surprising, given the high prevalence of psychiatric problems in the SpA's estimated to be 40-50% [50]. When present, they similarly obfuscate measures of severity [50,51].…”

Section: The Spondyloarthropathies (Spa)supporting

confidence: 72%

Recognize Comorbid Fibromyalgia Syndrome in Order to Better Evaluate Selected Rheumatic Diseases

Wilke¹

2018

Discussions of Unusual Topics in Fibromyalgia

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The prevalence of comorbid fibromyalgia syndrome in autoimmune rheumatic diseases is clinically significantly higher than is fibromyalgia syndrome in the general population. By increasing pain sensitivity and fatigue, it disproportionately inflates subjective signs and symptoms, thereby obfuscating composite indices used to measure biological disease activity, the degree of disability, and the quality of life. By modifying primary disease phenotype, it also interferes with diagnostic precision. This review documents its effects on rheumatoid arthritis, the spondyloarthropathies, and systemic lupus erythematosus; and offers a general remedial strategy.

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Section: The Spondyloarthropathies (Spa)supporting

confidence: 72%

Recognize Comorbid Fibromyalgia Syndrome in Order to Better Evaluate Selected Rheumatic Diseases

Wilke¹

2018

Discussions of Unusual Topics in Fibromyalgia

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“…We and others have previously found that reports of anxiety and depression are common in patients with SpA (12)(13)(14)(15)(16)(17)(18)35). It is also well known that patients with SpA often report high levels of fatigue, low general health, poor QoL, impaired function, and decreased self-efficacy, which all are known factors of importance for reports of anxiety and depression (12-15, 17, 36).…”

Section: Discussionmentioning

confidence: 89%

“…Among other factors, disease severity, physical disability, experiencing helplessness, and educational level may be associated with anxiety and depression in patients with rheumatic diseases (10,11). Studies that focus on diagnostic SpA subtypes point in the same direction for AS (12)(13)(14)(15) and PsA (16)(17)(18), while studies regarding USpA and mental health are rare. A recent population-based cohort study showed a 60% increase in the risk of developing a depressive disorder among AS patients compared to the general population (19).…”

mentioning

confidence: 99%

Prognostic factors for change in self-reported anxiety and depression in spondyloarthritis patients: data from the population-based SpAScania cohort from southern Sweden

Meesters

Bergman

Haglund

et al. 2017

Scandinavian Journal of Rheumatology

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“…Fatigue is a common symptom in AS, with two studies reporting a correlation with depression severity ( r ⩽ 0.55). 74 , 75 Considering these two studies were based on relatively small samples (80 and 65 cases of AS), the correlation estimates are relatively large and may indicate a significant role of fatigue in depression in patients with AS. Similarly, sleep quality appears to be related to depressive symptoms.…”

Section: Potential Mechanisms Of Depression In As or Psa Patientsmentioning

confidence: 99%

Depression in patients with spondyloarthritis: prevalence, incidence, risk factors, mechanisms and management

Parkinson

Foley

Jadon

et al. 2020

Therapeutic Advances in Musculoskeletal

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Depression is a major neuropsychiatric disorder common in patients with rheumatological conditions including spondyloarthritis (SpA). It is associated with higher disease activity, functional impairment, poor treatment response and quality of life in patients with musculoskeletal disorders. Using ankylosing spondylitis (AS) and psoriatic arthritis (PsA) as examples, we have reviewed the evidence regarding the burden, risk factors, potential mechanisms and clinical management of depression in spondyloarthritis. The prevalence of depression is higher in patients with AS and PsA compared with the general population, with evidence of moderate/severe depression in about 15% of patients with AS or PsA. Mild depression is even more common and estimated to be present in about 40% of patients with AS. In addition to conventional risk factors such as stressful life events and socioeconomic deprivation, increased risk of depression in SpA may be associated with disease-related factors, such as disease activity, poor quality of life, fatigue, and sleep disturbances. Emerging evidence implicates inflammation in the aetiology of depression, which could also be a shared mechanism for depression and chronic inflammatory conditions such as AS and PsA. It is imperative for clinicians to actively assess and treat depression in SpA, as this could improve treatment adherence, quality of life, and overall long-term clinical and occupational outcomes. The use of validated tools can aid recognition and management of depression in rheumatology clinics. Management of depression in SpA, especially when to refer to specialist mental health services, are discussed.

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Psychiatric symptoms in ankylosing spondylitis: their relationship with disease activity, functional capacity, pain and fatigue

Cited by 35 publications

References 32 publications

Recognize Comorbid Fibromyalgia Syndrome in Order to Better Evaluate Selected Rheumatic Diseases

Recognize Comorbid Fibromyalgia Syndrome in Order to Better Evaluate Selected Rheumatic Diseases

Prognostic factors for change in self-reported anxiety and depression in spondyloarthritis patients: data from the population-based SpAScania cohort from southern Sweden

Depression in patients with spondyloarthritis: prevalence, incidence, risk factors, mechanisms and management

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