Psychiatric symptoms after temporal epilepsy surgery. A one-year follow-up study

Iranzo-Tatay, Carmen; Rubio-Granero, Teresa; Gutiérrez, Antonio; Garcés, Mercedes; Conde, Rebeca; Gómez‐Ibáñez, Asier; Arques-Egea, Sergio; Sancho-Miñana, Lucia; Hervás, David; Villanueva, Vicente

doi:10.1016/j.yebeh.2017.02.029

Cited by 17 publications

(6 citation statements)

References 47 publications

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“…Majority of the previous studies report either an improvement or no change in the rates of anxiety post-surgery in keeping with our findings (Hamid et al 2014; Iranzo-Tatay et al 2017; Ramos-Perdigués et al 2018). However, worse rates have been reported with the indication that anxiety may be more prevalent within the first few days following surgery and resolve within the first 3 months (Desai et al 2014).…”

Section: Discussionsupporting

confidence: 92%

“…If the patients with psychosis due to GMC were excluded, the results still showed a reduction in the rate of psychotic disorder from 2.4% pre-operatively to 1.2% post-operatively. A few recent studies have examined the impact of surgery on psychosis and reported positive outcomes in keeping with our results (D’Alessio et al 2014; Iranzo-Tatay et al 2017). Buranee et al (2016) reported a significant reduction in epilepsy-related psychoses at 24 months post-surgery.…”

Section: Discussionsupporting

confidence: 90%

“…Several previous studies have attempted to identify predictive risk factors for psychiatric outcomes following epilepsy surgery. Some studies have found post-operative seizure control to be related to an improvement in measures of depression and anxiety (Devinsky et al 2005; Hamid et al 2011) although others have not been able to replicate these findings (Iranzo-Tatay et al 2017). A recent study by Iranzo-Tatay et al (2017) found that a history of mental illness was a risk factor for the presence of psychopathology after surgery.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have found post-operative seizure control to be related to an improvement in measures of depression and anxiety (Devinsky et al 2005; Hamid et al 2011) although others have not been able to replicate these findings (Iranzo-Tatay et al 2017). A recent study by Iranzo-Tatay et al (2017) found that a history of mental illness was a risk factor for the presence of psychopathology after surgery. A systematic review by Macrodimitris et al (2011) found that the two main predictors of psychiatric outcomes were seizure freedom and pre-surgical psychiatric history.…”

Section: Discussionmentioning

confidence: 99%

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Psychiatric and psychosocial morbidity 1 year after epilepsy surgery

Patel

Clancy

Barry

et al. 2020

Ir. j. psychol. Med.

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Objectives: There is a high rate of psychiatric comorbidity in patients with epilepsy. However, the impact of surgical treatment of refractory epilepsy on psychopathology remains under investigation. We aimed to examine the impact of epilepsy surgery on psychopathology and quality of life at 1-year post-surgery in a population of patients with epilepsy refractory to medication. Methods: This study initially assessed 48 patients with refractory epilepsy using the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), the Hospital Anxiety and Depression Scale (HADS) and the Quality of Life in Epilepsy Inventory 89 (QOLIE-89) on admission to an Epilepsy Monitoring Unit (EMU) as part of their pre-surgical assessment. These patients were again assessed using the SCID-I, QOLIE-89 and HADS at 1-year follow-up post-surgery. Results: There was a significant reduction in psychopathology, particularly psychosis, following surgery at 1-year follow-up (p < 0.021). There were no new cases of de novo psychosis and surgery was also associated with a significant improvement in the quality of life scores (p < 0.001). Conclusions: This study demonstrates the impact of epilepsy surgery on psychopathology and quality of life in a patient population with refractory surgery. The presence of a psychiatric illness should not be a barrier to access surgical treatment.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Psychiatric and psychosocial morbidity 1 year after epilepsy surgery

Patel

Clancy

Barry

et al. 2020

Ir. j. psychol. Med.

View full text Add to dashboard Cite

show abstract

“…31 However, there are reported cases of de novo psychosis after successful epilepsy surgery and, in these cases, the forced normalization phenomenon has been hypothesized. 32 While pre-existing psychiatric conditions, including psychotic disorders, could be a risk factor for psychiatric disorders after epilepsy surgery, 33 they should not represent a contraindication for epilepsy surgery per se . In fact, epilepsy surgery can result in improvement in other epilepsy-related symptoms such as peri-ictal psychoses and sometimes interictal psychoses.…”

Section: Psychotic Symptoms In Epilepsy: Phenomenology and Clinical Pmentioning

confidence: 99%

Treatment of psychoses in patients with epilepsy: an update

Agrawal

Mula

2019

Therapeutic Advances in Psychopharmacology

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Psychotic disorders represent a relatively rare but serious comorbidity in epilepsy. Current epidemiological studies are showing a point prevalence of 5.6% in unselected samples of people with epilepsy going up to 7% in patients with temporal lobe epilepsy, with a pooled odds ratio of 7.8 as compared with the general population. This is a narrative review of the most recent updates in the management of psychotic disorders in epilepsy, taking into account the clinical scenarios where psychotic symptoms occur in epilepsy, interactions with antiepileptic drugs (AEDs) and the risk of seizures with antipsychotics. Psychotic symptoms in epilepsy can arise in a number of different clinical scenarios from peri-ictal symptoms, to chronic interictal psychoses, comorbid schizophrenia and related disorders to the so-called forced normalization phenomenon. Data on the treatment of psychotic disorders in epilepsy are still limited and the management of these problems is still based on individual clinical experience. For this reason, guidelines of treatment outside epilepsy should be adopted taking into account epilepsy-related issues including interactions with AEDs and seizure risk. Second-generation antipsychotics, especially risperidone, can represent a reasonable first-line option because of the low propensity for drug–drug interactions and the low risk of seizures. Quetiapine is burdened by a clinically significant pharmacokinetic interaction with enzyme-inducing drugs leading to undetectable levels of the antipsychotic, even for dosages up to 700 mg per day.

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Can We Anticipate and Prevent the Occurrence of Iatrogenic Psychiatric Events Caused by Anti-seizure Medications and Epilepsy Surgery?

Filho

2021

Current Topics in Behavioral Neurosciences

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Psychiatric symptoms after temporal epilepsy surgery. A one-year follow-up study

Cited by 17 publications

References 47 publications

Psychiatric and psychosocial morbidity 1 year after epilepsy surgery

Psychiatric and psychosocial morbidity 1 year after epilepsy surgery

Treatment of psychoses in patients with epilepsy: an update

Can We Anticipate and Prevent the Occurrence of Iatrogenic Psychiatric Events Caused by Anti-seizure Medications and Epilepsy Surgery?

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