Psychiatric Problems of Living Kidney Transplantation in Child and Adolescent Recipients

Sato, Kiichiro; Akahoshi, Keiko; Suzuki, Yasuyo; Fukuyama, Yoshitsuna; Isomoto, Akihiko; Miura, S.

doi:10.1007/978-4-431-68525-8_17

Recent Progress in Child and Adolescent Psychiatry 1996

DOI: 10.1007/978-4-431-68525-8_17

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Psychiatric Problems of Living Kidney Transplantation in Child and Adolescent Recipients

Kiichiro Sato

Keiko Akahoshi

Yasuyo Suzuki

et al.

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2003

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“…Psychiatric disorders are more common in chronic dialysis patients than in the general population (3) and have been shown to adversely impact survival in hemodialysis patients (4). However, psychosis occurring after renal transplantation has been infrequently described (5)(6)(7)(8)(9). There are several potential reasons why renal transplantation may predispose patients to an increased risk of psychosis: use of high-dose corticosteroids, a known risk factor for psychosis (8); chronic illness-associated affective disorders; metabolic factors associated with renal transplantation; and other immunosuppressive medications used in transplantation, such as calcineurin inhibitors, which have known neuropsychologic side effects (10).…”

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Hospitalized Psychoses after Renal Transplantation in the United States

Abbott¹,

Agodoa

O’Malley

2003

Journal of the American Society of Nephrology

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ABSTRACT. Although it is recommended that renal transplant (RT) candidates routinely undergo screening for mental health–related conditions, national statistics for psychoses after RT have not been reported. This is a historical cohort study of 39,628 renal transplant recipients in the United States Renal Data System between July 1, 1994, and June 30, 1998, and followed until December 31, 1999. Adjusted hazard ratios (AHR) for time to hospitalization for both a primary and secondary discharge diagnosis of psychoses (ICD-9 codes 290.x-299.x) after RT and mortality/graft loss after psychosis were assessed by Cox Regression. In addition, rates of psychosis were compared with 178,986 patients with Medicare as their primary payer who started chronic dialysis from April 1, 1995, to June 29, 1999. The incidence of psychoses was 7.5/1000 person-years (PY) after RT compared with 7.2/1000 PY for all patients on chronic dialysis and 9.6/1000 PY for dialysis patients aged 65 yr or younger. Among RT recipients, graft loss (AHR, 2.97; 95% CI, 2.19 to 4.02), allograft rejection, and cadaveric donation were independently associated with psychosis, which was associated with an increased risk of both death (AHR, 2.09; 95% CI, 1.71 to 2.56; P < 0.001) and graft loss (AHR, 1.79; 95% CI, 1.15 to 2.78; P = 0.01). Graft loss due to noncompliance was significantly more common after psychosis (9.0% versus 3.7% in patients not hospitalized for psychosis; P < 0.001). The incidence of hospitalized psychosis was not substantially higher after RT compared with chronic dialysis patients. Psychoses were independently associated with increased risk of death and graft loss after renal transplantation, possibly mediated through medical non-adherence. E-mail: kevin.abbott@na.amedd.army.mil

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confidence: 99%

Hospitalized Psychoses after Renal Transplantation in the United States

Abbott¹,

Agodoa

O’Malley

2003

Journal of the American Society of Nephrology

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Psychiatric Problems of Living Kidney Transplantation in Child and Adolescent Recipients

Cited by 1 publication

References 15 publications

Hospitalized Psychoses after Renal Transplantation in the United States

Hospitalized Psychoses after Renal Transplantation in the United States

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