Psychiatric outcome studies (POS): Does treatment help the patients? A Popperian approach to research in clinical psychiatry

Bech, Per; Lunde, Marianne; Bech-Andersen, G.; Lindberg, Lone; Martiny, Klaus

doi:10.1080/08039480601151238

Cited by 39 publications

(31 citation statements)

References 181 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Results indicated that each of the six scale items contributed significantly to the measurement (both for patients and clinicians) and that HAM-D 6 responses indeed measure a single depression construct. These findings are in accord with previously reported findings [13-15,25,26,33]. …”

Section: Discussionsupporting

confidence: 94%

“…As previously mentioned, Bech et al [33] suggest that a HAM-D 6 score of 7+ is suggestive of clinically significant depressive symptoms (i.e., warranting thorough clinical assessment). Comparing patient and clinician ratings, agreement as calculated using the kappa coefficient was in fair range (k = .26; [34]).…”

Section: Resultsmentioning

confidence: 99%

“…Items are provided along 5-point scales, with the exception of the somatic symptoms item (where responses were provided on a 3-point scale). As a screening measure, scores of 7+ suggest clinically significant depressive symptomatology [33]. Whereas the self-report HAM-D 6 is based solely on patient responses, the clinician-administered version integrates patients’ responses and clinical observation.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Psychometric properties of responses by clinicians and older adults to a 6-item Hebrew version of the Hamilton Depression Rating Scale (HAM-D6)

et al. 2013

View full text Add to dashboard Cite

BackgroundThe Hamilton Depression Rating Scale (HAM-D) is commonly used as a screening instrument, as a continuous measure of change in depressive symptoms over time, and as a means to compare the relative efficacy of treatments. Among several abridged versions, the 6-item HAM-D6 is used most widely in large degree because of its good psychometric properties. The current study compares both self-report and clinician-rated versions of the Hebrew version of this scale.MethodsA total of 153 Israelis 75 years of age on average participated in this study. The HAM-D6 was examined using confirmatory factor analytic (CFA) models separately for both patient and clinician responses.ResultsReponses to the HAM-D6 suggest that this instrument measures a unidimensional construct with each of the scales’ six items contributing significantly to the measurement. Comparisons between self-report and clinician versions indicate that responses do not significantly differ for 4 of the 6 items. Moreover, 100% sensitivity (and 91% specificity) was found between patient HAM-D6 responses and clinician diagnoses of depression.ConclusionThese results indicate that the Hebrew HAM-D6 can be used to measure and screen for depressive symptoms among elderly patients.

show abstract

Section: Discussionsupporting

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Psychometric properties of responses by clinicians and older adults to a 6-item Hebrew version of the Hamilton Depression Rating Scale (HAM-D6)

et al. 2013

View full text Add to dashboard Cite

show abstract

“…At the end point, the participants in the group had obtained a level of 69. However, the difference at the end point between the active group and the control group was approximately 3 on the WHO-5, which is statistically significant but not clinically significant, since the threshold for a clinically relevant change is considered to be 10 points on the WHO-5 [27]. …”

Section: Resultsmentioning

confidence: 99%

The WHO-5 Well-Being Index: A Systematic Review of the Literature

Topp

Østergaard

Søndergaard

et al. 2015

Psychother Psychosom

3,050

2,571

View full text Add to dashboard Cite

Background: The 5-item World Health Organization Well-Being Index (WHO-5) is among the most widely used questionnaires assessing subjective psychological well-being. Since its first publication in 1998, the WHO-5 has been translated into more than 30 languages and has been used in research studies all over the world. We now provide a systematic review of the literature on the WHO-5. Methods: We conducted a systematic search for literature on the WHO-5 in PubMed and PsycINFO in accordance with the PRISMA guidelines. In our review of the identified articles, we focused particularly on the following aspects: (1) the clinimetric validity of the WHO-5; (2) the responsiveness/sensitivity of the WHO-5 in controlled clinical trials; (3) the potential of the WHO-5 as a screening tool for depression, and (4) the applicability of the WHO-5 across study fields. Results: A total of 213 articles met the predefined criteria for inclusion in the review. The review demonstrated that the WHO-5 has high clinimetric validity, can be used as an outcome measure balancing the wanted and unwanted effects of treatments, is a sensitive and specific screening tool for depression and its applicability across study fields is very high. Conclusions: The WHO-5 is a short questionnaire consisting of 5 simple and non-invasive questions, which tap into the subjective well-being of the respondents. The scale has adequate validity both as a screening tool for depression and as an outcome measure in clinical trials and has been applied successfully across a wide range of study fields.

show abstract

“…A sample size calculation was carried out to detect a 10-point higher score on the WHO-5 at 29–34 weeks of gestation in the intervention group compared with the control group. A 10-point difference in the WHO-5 score between the intervention and control groups is considered clinically significant [28, 29], and an SD of 16 was used. This SD is based on a previous assessment of the WHO-5 score in a population of 3970 pregnant women with and without mental disorders measured at 10–12 weeks of gestation in the total population of pregnant women at Rigshospitalet, Copenhagen University Hospital.…”

Section: Methodsmentioning

confidence: 99%

Effect of supervised exercise in groups on psychological well-being among pregnant women at risk of depression (the EWE Study): study protocol for a randomized controlled trial

Broberg

Backhausen

Damm

et al. 2017

Trials

View full text Add to dashboard Cite

BackgroundPregnant women with depression and/or anxiety prior to pregnancy are at higher risk of preterm birth, breastfeeding problems, postpartum depression, and disruption of the mother-infant attachment. It is well documented that exercise improves psychological well-being in nonpregnant subjects with symptoms of depression. However, in only a few small studies have researchers examined the effect of exercise on symptoms of depression among pregnant women. We hypothesize that physiotherapist-supervised group exercise for pregnant women at risk of antenatal depression increases their psychological well-being. This paper describes the study protocol of a randomized controlled trial (RCT) on a supervised group exercise intervention for pregnant women with a current or previous history of depression and/or anxiety.Methods/designThe RCT is being carried out at the Department of Obstetrics, Rigshospitalet, Copenhagen University Hospital, in the period 2016–2019. The inclusion criteria are pregnant women ≥18 years of age with depression and/or anxiety requiring treatment by a psychiatrist or a psychologist within the last 10 years and/or intake of antidepressants in the 3 months prior to conception and/or during pregnancy. The women must have appropriate Danish language skills, be pregnant with a single fetus, give written informed consent, and be at 17–22 gestational weeks when the intervention begins. The primary outcome is psychological well-being (the five-item World Health Organization Well-being Index). Secondary outcomes are symptoms of depression (Edinburgh Postnatal Depression Scale), functional ability (General Health Questionnaire), clinical symptoms of anxiety (State-Trait Anxiety Inventory), sleep quality and sleep disturbances (Pittsburgh Sleep Quality Index), and pregnancy and delivery outcomes. The intervention is supervised group exercise twice weekly for 12 weeks. The control group will receive standard antenatal care. On the basis of sample size calculation, a total of 300 women will be randomly assigned to either the intervention or the control group in a ratio of 1:1.DiscussionThe trial is expected to contribute to the body of knowledge used in planning antenatal care for pregnant women at risk of depression.Trial registrationClinicalTrials.gov, NCT02833519. Registered on 19 May 2016.Electronic supplementary materialThe online version of this article (doi:10.1186/s13063-017-1938-z) contains supplementary material, which is available to authorized users.

show abstract

Psychiatric outcome studies (POS): Does treatment help the patients? A Popperian approach to research in clinical psychiatry

Cited by 39 publications

References 181 publications

Psychometric properties of responses by clinicians and older adults to a 6-item Hebrew version of the Hamilton Depression Rating Scale (HAM-D6)

Psychometric properties of responses by clinicians and older adults to a 6-item Hebrew version of the Hamilton Depression Rating Scale (HAM-D6)

The WHO-5 Well-Being Index: A Systematic Review of the Literature

Effect of supervised exercise in groups on psychological well-being among pregnant women at risk of depression (the EWE Study): study protocol for a randomized controlled trial

Contact Info

Product

Resources

About