Psychiatric genetic counseling: A mapping exercise

Moldovan, Ramona; McGhee, Kevin A.; Coviello, Domenico; Hamang, Anniken; Inglis, Angela; Malmgren, Charlotta Ingvoldstad; Johansson‐Soller, Maria; Laurino, Mercy; Meiser, Bettina; Murphy, Lauren; Paneque, Milena; Papsuev, Oleg; Pawlak, Joanna; Rovira-Moreno, Eulàlia; Serra‐Juhé, Clara; Shkedi‐Rafid, Shiri; Laing, Nakita; Voelckel, Marie‐Antoinette; Watson, Mark; Austin, Jehannine

doi:10.1002/ajmg.b.32735

Cited by 21 publications

(43 citation statements)

References 79 publications

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“…In addition to concerns about the long-term impact of true genotypic information for psychiatric conditions and concerns about relaying true complex genetic risk information, there are also feasibility concerns about the process of returning genotypic information. Psychiatric genetic counseling is an established and growing field (Moldovan et al, 2019) that has demonstrated positive patient outcomes such as empowerment and increased self-efficacy (Austin, 2019;Inglis et al, 2015). Not only are there a limited number of specialized psychiatric genetic counselors (Moldovan et al, 2019), but there is also a shortage of genetic counselors which is projected to last for another 5-10 years (Hoskovec et al, 2018).…”

Section: Summary and Future Directionsmentioning

confidence: 99%

“…Psychiatric genetic counseling is an established and growing field (Moldovan et al, 2019) that has demonstrated positive patient outcomes such as empowerment and increased self-efficacy (Austin, 2019;Inglis et al, 2015). Not only are there a limited number of specialized psychiatric genetic counselors (Moldovan et al, 2019), but there is also a shortage of genetic counselors which is projected to last for another 5-10 years (Hoskovec et al, 2018). Even when genetic counselors are accessible, data suggest that many genetic counselors do not feel prepared to discuss psychiatric conditions with patients (Appelbaum & Benston, 2017;Low, Dixon, Higgs, Joines, & Hippman, 2018).…”

Section: Summary and Future Directionsmentioning

confidence: 99%

“…Even when genetic counselors are accessible, data suggest that many genetic counselors do not feel prepared to discuss psychiatric conditions with patients (Appelbaum & Benston, 2017;Low, Dixon, Higgs, Joines, & Hippman, 2018). It will be important to understand why genetic counselors feel unprepared to discuss psychiatric conditions, as well as to broaden the training of genetic counselors to include addressing psychiatric conditions and helping individuals understand complex genotypic information for psychiatric conditions (Low et al, 2018;Moldovan et al, 2019). With the complex nature of genetic risk for psychiatric conditions, efforts to identify, design, and implement effective educational methods for improving genetic knowledge relevant for understanding complex conditions is especially important.…”

Section: Summary and Future Directionsmentioning

confidence: 99%

See 2 more Smart Citations

Genetic feedback for psychiatric conditions: Where are we now and where are we going

Driver

Kuo

Dick

2020

American J of Med Genetics Pt B

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Genome‐wide association studies are rapidly advancing our understanding of the genetic architecture of complex disorders, including many psychiatric conditions such as major depression, schizophrenia, and substance use disorders. One common goal of genome‐wide association studies is to use findings for enhanced clinical prediction in the future, which can aid in identifying at‐risk individuals to enable more effective prevention screening and treatment strategies. In order to achieve this goal, we first need to gain a better understanding of the issues surrounding the return of complex genetic results. In this article, we summarize the current literature on: (a) genetic literacy in the general population, (b) the public's interest in receiving genetic test results for psychiatric conditions, (c) how individuals react to and interpret their genotypic information for specific psychiatric conditions, and (d) gaps in our knowledge that will be critical to address as we move toward returning genotypic information for psychiatric conditions in both research and clinical settings. By reviewing extant studies, we aim to increase awareness of the potential benefits and consequences of returning genotypic information for psychiatric conditions.

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Section: Summary and Future Directionsmentioning

confidence: 99%

Section: Summary and Future Directionsmentioning

confidence: 99%

Section: Summary and Future Directionsmentioning

confidence: 99%

See 1 more Smart Citation

Genetic feedback for psychiatric conditions: Where are we now and where are we going

Driver

Kuo

Dick

2020

American J of Med Genetics Pt B

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“…However, it is unclear whether these outcomes can be replicated elsewhere [40]. Research shows that many genetic counselors are uncomfortable discussing psychiatric genetics with patients [41, 42] and have negative attitudes toward individuals with such conditions [43], and that, though it is a growing discipline, psychiatric genetic counseling is – as yet – neither routinely nor widely offered [44]. Although efforts to rectify these issues are underway, the challenges are compounded in the USA, where the health-care settings are markedly different than those in the Canadian clinics, including the latter’s national health-care coverage and unique training of genetic counselors who provide this service [24].…”

Section: Discussionmentioning

confidence: 99%

Teenagers and Precision Psychiatry: A Window of Opportunity

Sabatello

Chen

Herrera

et al. 2021

Public Health Genomics

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Objective: Precision medicine raises hope for translating genetic-based knowledge about psychiatric risks into mental health benefits by motivating health-related, risk-reducing behaviors. Teenagers (ages 14–17) are an important age-group to engage in preventive efforts but, their views about psychiatric genetics are understudied. Method: An online survey with a nationally representative sample of teenagers (n = 417) was conducted. Participants were randomly assigned to receive 1 of 2 handouts, 1 emphasizing the genetic underpinnings of psychiatric conditions; the other agency-oriented and focusing on gene-environment interactions. Survey questions queried their views about behavioral changes in response to psychiatric genetic risk information and expressed willingness to undertake them. Participants’ decision-making characteristics (i.e., self-efficacy, empowerment, intolerance of uncertainty, and sensation-seeking) were assessed at baseline. Results: Teenagers strongly valued the information provided and its potential usefulness for their mental health. Information about psychiatric genetics alone impacted views about the causes of mental illness. Contrary to our hypothesis, the type of handout did not impact participants’ expressed willingness to make behavioral changes to reduce their risk of developing a psychiatric condition, but their sense of empowerment played a key role in their responses. Conclusion: Educating teenagers about gene-environment interactions may help facilitate the translational efforts of precision psychiatry. Research with teenagers across racial/ethnic groups, especially those with family histories, is needed to better understand the factors that impact teenagers’ empowerment in psychiatric genomic settings and to identify measures, including the best enablers of empowerment (e.g., educators, parents), which would allow them to reap the benefits of precision psychiatry.

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“…Three of these articles present international efforts to address ELSI issues related to psychiatric genetics research and translation. Moldovan and colleagues () examine the current state of psychiatric genetic counseling around the world and the importance of expanding training and access to these services. Importantly, they note that psychiatric genetic counseling is not only useful when a genetic test is conducted but also to help patients understand and manage the implications of genetic contributions to mental health.…”

mentioning

confidence: 99%