Psychiatric Evaluation of Death-Hastening Requests

Cohen, Lewis M.; Steinberg, Marvin E.; Hails, Kevin C.; Dobscha, Steven K.; Fischel, Steven V.

doi:10.1176/appi.psy.41.3.195

Cited by 29 publications

(10 citation statements)

References 73 publications

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“…For example, these studies did not distinguish clearly between a general wish to die, the WTHD and requests for euthanasia or PAS. Thus, one finds the indistinct use of terms such as ‘ wish to die ’ 28, ‘ want to die ’ 29 or ‘ desire to die ’ 30, 31, as well as ‘ wish to hasten death ’ 6, 22, ‘ desire for early death ’ 32 and other related expressions for requests for euthanasia or assisted suicide, such as ‘ death‐hastening request ’ 33, ‘ request to die ’ 34, ‘ request for euthanasia ’ 35 and ‘ request for physician‐assisted suicide ’ 36. Table 5 shows the number of studies identified that use each of these terms.…”

Section: Discussionmentioning

confidence: 99%

Mechanistic Aspects of hSOD1 Maturation from the Solution Structure of Cu^I‐Loaded hCCS Domain 1 and Analysis of Disulfide‐Free hSOD1 Mutants

Banci¹,

Cantini²,

Kozyreva³

et al. 2013

ChemBioChem

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Superoxide dismutase 1 (SOD1) maturation within the cell is mainly accomplished with the SOD1-specific chaperone, CCS, a dimeric protein with three distinct domains in each monomer. We recently showed that the first domain of human CCS (hCCSD1) is responsible for copper transfer to its protein partner, human SOD1 (hSOD1). The NMR solution structure of the copper(I)-loaded form of hCCSD1 reported here contributes further to characterization of the copper-transfer mechanism to hSOD1. NMR spectroscopy was also used to examine the hSOD1 mutants C57A, C146A, and C57A/C146A, which are unable to form the structurally conserved disulfide bond in SOD1, in order to investigate the role of these cysteines during hSOD1 copper acquisition. Together, the information on both hCCS and hSOD1, along with a sequence analysis of eukaryotic CCSD1, allows us to propose important mechanistic aspects regarding the copper-transfer process from hCCS to hSOD1.

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Section: Discussionmentioning

confidence: 99%

Mechanistic Aspects of hSOD1 Maturation from the Solution Structure of Cu^I‐Loaded hCCS Domain 1 and Analysis of Disulfide‐Free hSOD1 Mutants

Banci¹,

Cantini²,

Kozyreva³

et al. 2013

ChemBioChem

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“…Indeed, studies have not distinguished clearly between a general wish to die, the wish to hasten death and requests for euthanasia or physician-assisted suicide [8]. Thus, one finds the indistinct use of terms such as ‘wish to die’ [9], ‘want to die’ [10] or ‘desire to die’ [11], [12], as well as ‘wish to hasten death’ [13], [14], ‘desire for early death’ [15] and other related expressions or synonyms for requests for euthanasia or assisted suicide, such as ‘death-hastening request’ [16], ‘request to die’ [17], ‘request for euthanasia’ [18] and ‘request for physician-assisted suicide’ [19].…”

Section: Introductionmentioning

confidence: 99%

What Lies behind the Wish to Hasten Death? A Systematic Review and Meta-Ethnography from the Perspective of Patients

et al. 2012

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BackgroundThere is a need for an in-depth approach to the meaning of the wish to hasten death (WTHD). This study aims to understand the experience of patients with serious or incurable illness who express such a wish.Methods and FindingsSystematic review and meta-ethnography of qualitative studies from the patient's perspective. Studies were identified through six databases (ISI, PubMed, PsycINFO, CINAHL, CUIDEN and the Cochrane Register of Controlled Trials), together with citation searches and consultation with experts. Finally, seven studies reporting the experiences of 155 patients were included. The seven-stage Noblit and Hare approach was applied, using reciprocal translation and line-of-argument synthesis. Six main themes emerged giving meaning to the WTHD: WTHD in response to physical/psychological/spiritual suffering, loss of self, fear of dying, the desire to live but not in this way, WTHD as a way of ending suffering, and WTHD as a kind of control over one's life (‘having an ace up one's sleeve just in case’). An explanatory model was developed which showed the WTHD to be a reactive phenomenon: a response to multidimensional suffering, rather than only one aspect of the despair that may accompany this suffering. According to this model the factors that lead to the emergence of WTHD are total suffering, loss of self and fear, which together produce an overwhelming emotional distress that generates the WTHD as a way out, i.e. to cease living in this way and to put an end to suffering while maintaining some control over the situation.ConclusionsThe expression of the WTHD in these patients is a response to overwhelming emotional distress and has different meanings, which do not necessarily imply a genuine wish to hasten one's death. These meanings, which have a causal relationship to the phenomenon, should be taken into account when drawing up care plans.

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“…Even for trained psychodiagnosticians, identifying depression can be complicated because of somatic symptoms such as fatigue, anorexia, psychomotor slowing, and insomnia common to both cancer and depression [16]. Recently developed standardized brief assessments with structured response options may be a feasible alternative for very sick patients, as shown in studies of patients with other terminal illnesses [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Depression, distress and positive mood in late‐stage cancer: a longitudinal study

Rabkin

McElhiney²,

Moran³

et al. 2008

Psycho-Oncology

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In this exploratory study, terminally ill patients approaching death experienced positive as well as negative mood although a significant minority met criteria for major depression at the last visit before death. The findings suggest that major depression is not an inevitable part of the dying process in patients with terminal cancer. Further, the appropriateness of classifying sadness, loss of interest and thoughts that one would be better off dead in the last days of life as psychopathology should be reconsidered.

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Psychiatric Evaluation of Death-Hastening Requests

Cited by 29 publications

References 73 publications

Mechanistic Aspects of hSOD1 Maturation from the Solution Structure of Cu^I‐Loaded hCCS Domain 1 and Analysis of Disulfide‐Free hSOD1 Mutants

Mechanistic Aspects of hSOD1 Maturation from the Solution Structure of Cu^I‐Loaded hCCS Domain 1 and Analysis of Disulfide‐Free hSOD1 Mutants

What Lies behind the Wish to Hasten Death? A Systematic Review and Meta-Ethnography from the Perspective of Patients

Depression, distress and positive mood in late‐stage cancer: a longitudinal study

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Psychiatric Evaluation of Death-Hastening Requests

Cited by 29 publications

References 73 publications

Mechanistic Aspects of hSOD1 Maturation from the Solution Structure of CuI‐Loaded hCCS Domain 1 and Analysis of Disulfide‐Free hSOD1 Mutants

Mechanistic Aspects of hSOD1 Maturation from the Solution Structure of CuI‐Loaded hCCS Domain 1 and Analysis of Disulfide‐Free hSOD1 Mutants

What Lies behind the Wish to Hasten Death? A Systematic Review and Meta-Ethnography from the Perspective of Patients

Depression, distress and positive mood in late‐stage cancer: a longitudinal study

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Mechanistic Aspects of hSOD1 Maturation from the Solution Structure of Cu^I‐Loaded hCCS Domain 1 and Analysis of Disulfide‐Free hSOD1 Mutants

Mechanistic Aspects of hSOD1 Maturation from the Solution Structure of Cu^I‐Loaded hCCS Domain 1 and Analysis of Disulfide‐Free hSOD1 Mutants