Psychiatric Epidemiology of an Indian Village

Kinzie, J. David; Leung, Paul; Boehnlein, James K.; D, Matsunaga; Johnson, Robert A.; Manson, Spero M.; Shore, James H.; Heinz, John P.; Williams, Mary

doi:10.1097/00005053-199201000-00008

Cited by 64 publications

(56 citation statements)

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“…Information on the prevalence of alcoholism in Native Americans, as quantified by structured interview instruments, has generally been limited to select local communities. In these studies, alcohol dependence rates of approximately 65-80% for men and 37-55% for women have been reported [Kinzie et al, 1992;Robin et al, 1998;Kunitz et al, 1999;Gilder et al, 2003;Wall et al, 2003]. These rates, which are high compared to the general US population, are consistent with the high rates of alcohol related morbidity and mortality reported and confirm the urgent public health problem that alcohol dependence represents to many Native American communities.…”

Section: Introductionsupporting

confidence: 69%

Genomic screen for loci associated with alcohol dependence in Mission Indians

Ehlers

Gilder

Wall

et al. 2004

American J of Med Genetics Pt B

100

125

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Alcohol dependence is a leading cause of morbidity and mortality in Native Americans, yet biological factors underlying the disorder in this ethnic group remain elusive. This study's aims were to map susceptibility loci for DSM-III-R alcohol dependence and two narrower alcohol-related phenotypes in Mission Indian families. Each participant gave a blood sample and completed an interview using the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA) that was used to make alcohol dependence diagnoses and the narrower phenotypes of withdrawal, and drinking severity. Genotypes were determined for a panel 791 microsatellite polymorphisms. Analyses of multipoint variance component LOD scores for the dichotomous DSM-III-R phenotype revealed no peak LOD scores that exceeded 2.0 at any chromosome location. Two chromosomes, 4 and 12, had peak LOD scores that exceeded 2 for the alcohol use severity phenotype and three chromosomes 6, 15, 16 were found to have peaks with LOD scores that exceeded 2 for the withdrawal phenotype. Evidence for linkage to chromosomes 4 and 15, and 16 have been reported previously for alcohol related phenotypes whereas no evidence has as yet been reported for chromosomes 6 and 12. Combined linkage and association analysis suggest that alcohol dehydrogenase 1B gene polymorphisms are partially responsible for the linkage result on chromosome 4 in this population. These results corroborate the importance of several chromosomal regions highlighted in prior segregation studies in alcoholism and further identify new regions of the genome that may be unique to either the restricted phenotypes evaluated or this population of Mission Indians.

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Section: Introductionsupporting

confidence: 69%

Genomic screen for loci associated with alcohol dependence in Mission Indians

Ehlers

Gilder

Wall

et al. 2004

American J of Med Genetics Pt B

100

125

View full text Add to dashboard Cite

show abstract

“…Studies of psychiatric prevalence have tended to focus on one cultural group [9,10], a specific age group [11][12][13], a single gender [4] or a specific diagnosis such as alcohol abuse and dependence [14][15][16] or posttraumatic stress disorder [17]. Due to the lack of representative research, policies and funding decisions often have been based on service utilization studies rather than epidemiological information [18][19][20].…”

Section: Studies Of Mental Disorder Among American Indian Adultsmentioning

confidence: 99%

Mental disorders among parents/caretakers of American Indian early adolescents in the Northern Midwest*

Whitbeck

Hoyt

Johnson

et al. 2006

Soc Psychiat Epidemiol

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“…Extremely high rates of alcoholism have been observed in some American Indian populations, i.e., approximately 80% in men and 50% in women. Nevertheless, no evidence suggests that alcoholism in American Indians departs from the basic sex/ socioeconomic trends observed in other ethnic groups [Brown et al, 1993;Kinzie et al, 1992].Well-defined populations such as American Indian tribes are advantageous for identifying the causes underlying complex diseases [Lander and Schork, 1994]. Such populations are often more genetically and environmentally homogeneous than the general population; they are geographically restricted, and large families are common.…”

mentioning

confidence: 99%

Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an american indian population

et al. 1998

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To identify specific genes affecting vulnerability or resistance, we performed a whole-autosomal genome scan for genetic linkage to alcohol dependence in a Southwestern American Indian tribe. Genotypes at 517 autosomal microsatellite loci and clinical evaluations were available for 152 subjects belonging to extended pedigrees and forming 172 sib-pairs. Highly suggestive evidence for linkage emerged for two genomic regions using two- and multipoint sib-pair regression methods; both regions harbored neurogenetic candidate genes. The best evidence is seen with D11S1984 (nominal P = 0.00007, lod approximately equal to 3.1) on chromosome 11p, in close proximity to the DRD4 dopamine receptor and tyrosine hydroxylase (TH) genes. Good evidence is seen with D4S3242 (nominal P = 0.0002, lod approximately equal to 2.8) on chromosome 4p, near the beta1 GABA receptor gene. Interestingly, three loci in the alcohol dehydrogenase gene cluster on chromosome 4q showed evidence for linkage with two-point analyses, but not multipoint analysis.

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Psychiatric Epidemiology of an Indian Village

Cited by 64 publications

References 0 publications

Genomic screen for loci associated with alcohol dependence in Mission Indians

Genomic screen for loci associated with alcohol dependence in Mission Indians

Mental disorders among parents/caretakers of American Indian early adolescents in the Northern Midwest*

Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an american indian population

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