Psychiatric Effects of the Anticonvulsant Regimens

Rivinus, Timothy M.

doi:10.1097/00004714-198206000-00003

Cited by 27 publications

(20 citation statements)

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“…Many of the AEDs are used in psychiatry as mood stabilizers, but other effects of the medications are less well understood. The following is a review of the psychotropic effects of commonly used AEDs (Table 1) [80][81][82][83].…”

Section: Antiepileptic Medicationsmentioning

confidence: 99%

“…They are well known to cause sedation in many patients and a syndrome of hyperactivity, irritability, and aggression in young and elderly patients [81]. They have been linked to worsening depression and suicidal ideation in patients who have a family history of depression [82].…”

Section: Barbituratesmentioning

confidence: 99%

“…A large volume of literature suggests that it has a number of adverse effects, including sedation [81], psychosis [83], and encephalopathy [82]. It has been studied in bipolar disorder and found to be superior to placebo when used with haloperidol [84], although other studies suggest that it is comparable to placebo [85].…”

Section: Phenytoinmentioning

confidence: 99%

“…They are used widely as anxiolytics in psychiatry but may contribute to sedation and lead to dependence. Paradoxical reactions can occur in which patients become aggressive, irritable, and hyperactive [81]. The medications must be tapered slowly when discontinued, because rapid withdrawal at times can lead to exacerbation of seizures or even coma [81].…”

Section: Benzodiazepinesmentioning

confidence: 99%

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Psychiatric Aspects of Epilepsy

Marcangelo

Ovsiew

2007

Psychiatric Clinics of North America

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Section: Antiepileptic Medicationsmentioning

confidence: 99%

Section: Barbituratesmentioning

confidence: 99%

Section: Phenytoinmentioning

confidence: 99%

Section: Benzodiazepinesmentioning

confidence: 99%

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Psychiatric Aspects of Epilepsy

Marcangelo

Ovsiew

2007

Psychiatric Clinics of North America

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“…These include standard AEDs, such as ethosuximide, phenytoin, phenobarbital, and primidone [48], as well as the newer AEDs, like vigabatrin [45], lamotrigine, topiramate, and levetiracetam (Kanner, unpublished data). The clinical differentiation between alternative psychosis versus a toxic reaction can be difficult if a seizure-free state followed the introduction of the AED.…”

Section: Iatrogenic Psychotic Disordersmentioning

confidence: 99%

Neuropsychiatric complications of epilepsy

Kanner

Palac

2002

Curr Neurol Neurosci Rep

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Psychiatric complications of epilepsy are multiple and result from the complex interaction between endogenous, genetic, therapeutic, and environmental factors. The relationship between epilepsy and psychiatric disorders may be much closer than previously appreciated. Recent studies have suggested the existence of a bi-directional relationship between depression and epilepsy, whereby patients with epilepsy have a higher risk than the general population of suffering from depression, not only after, but also before the onset of epilepsy. Furthermore, similar neurotransmitter changes have been identified in depression and epilepsy, suggesting the possibility that these two disorders share common pathogenic mechanisms. Although the clinical manifestations of psychiatric disorders in epilepsy are often indistinguishable from those of nonepileptic patients, certain types of depression and psychotic disorders may present with clinical characteristics that are particular to epilepsy patients. These include the psychosis of epilepsy, postictal psychotic disorders, alternative psychosis (or forced normalization), and certain forms of interictal depressive disorders.

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Anticonvulsant Therapy After Neonatal Seizures—How Long Should it Be Continued?

Gál

1985

Pharmacotherapy

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The risk of epilepsy or afebrile seizures after convulsions in the neonatal period is compared with the benefits and risks of chronic use of anticonvulsants in infants. The best predictor of later seizures appears to be the presence of moderate to severe neurologic damage. In the absence of such deficits, the risk is below 10%, but increases to 50-70% when damage is severe. A comparison of reports indicates no difference in seizure recurrence rates when anticonvulsants are stopped early in the neonatal period or when treatment is longer, even in the high-risk group. After phenobarbital is discontinued and the plasma concentration falls below the therapeutic range, seizures usually recur within a few days or not for several months. Only 50% of these seizure types are expected to be controlled with phenobarbital. Long-term phenobarbital use is associated with impaired cognitive function in infants and toddlers, and retarded brain growth in rodent studies.

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Psychiatric Effects of the Anticonvulsant Regimens

Cited by 27 publications

References 0 publications

Psychiatric Aspects of Epilepsy

Psychiatric Aspects of Epilepsy

Neuropsychiatric complications of epilepsy

Anticonvulsant Therapy After Neonatal Seizures—How Long Should it Be Continued?

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