“…According to the Global Burden of Disease Study from 2019, anxiety and depressive diseases remain among the top ten leading causes of burden worldwide ( Collaborators 2022 ). In 2020, when the coronavirus-19 disease (COVID-19) pandemic emerged, a globally increased prevalence of anxiety and depression and the related burden was consistently identified ( Paez, Nicolalde et al 2022 ). The phytopharmacotherapeutic agent Silexan represents a proprietary active substance manufactured for oral administration from Lavandula angustifolia that repeatedly showed favorable safety profile and anxiolytic efficacy in subthreshold and generalized anxiety disorder (GAD), and in mixed anxiety and depressive disorder (MADD).…”