Psychiatric disorders in persistent and remitted Sydenham's chorea

Moreira, Janaína Matos; Kümmer, Arthur; Harsányi, Estefânia; Cardoso, Francisco; Teixeira, Antônio Lúcio

doi:10.1016/j.parkreldis.2013.10.029

Cited by 31 publications

(23 citation statements)

References 12 publications

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“…reported that anxiety is more common in females with Sydenham's chorea than in males ( p =0.003). This finding is supported by Moreira et al., who also found that females with Sydenham's chorea exhibited more anxiety symptoms than males ( p =0.03). In addition, all of the case studies included in this review – which typically depict unusual or extreme presentations of Sydenham's chorea, such as those with associated psychosis – were of females.…”

Section: Resultssupporting

confidence: 64%

“…Moreira et al . looked at a number of psychiatric conditions, including ADHD, OCD, and anxiety disorders.…”

Section: Resultsmentioning

confidence: 99%

“…One case–control study, using DSM‐IV criteria, found that depression was statistically significantly more common among individuals with Sydenham's chorea ( n =20) than in comparison participants . Moreira et al . found that the most frequent psychiatric disorders in individuals with Sydenham's chorea were depression and anxiety disorders, such as social phobia.…”

Section: Resultsmentioning

confidence: 99%

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Neuropsychiatric manifestations of Sydenham's chorea: a systematic review

Punukollu

Mushet

Linney³

et al. 2015

Develop Med Child Neuro

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OCDObsessive-compulsive disorder PANDAS Paediatric autoimmune neuropsychiatric disorders associated with streptococcal infections AIM Sydenham's chorea is a post-streptococcal, autoimmune, neuropsychiatric movement disorder. Sydenham's chorea is a major criterion for diagnosis of acute rheumatic fever with the implication of potential long-term sequelae including cardiac complications. It is well established that there is psychiatric comorbidity in Sydenham's chorea, but there are variations in the literature regarding the nature and prevalence of psychiatric diagnoses associated with Sydenham's chorea. The aim of this review was to systematically evaluate the evidence for psychiatric symptoms presenting with Sydenham's chorea. Knowledge of comorbid psychiatric symptomatology will support early diagnosis and treatment, leading to improved long-term outcomes for children with Sydenham's chorea.METHOD The study used a systematic search strategy, using MEDLINE, MEDLINE in Process, EMBASE, and The Cochrane Library. Abstracts were screened to identify relevant papers which were then assessed further. Eligible papers were summarized.

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Section: Resultssupporting

confidence: 64%

“…Moreira et al . looked at a number of psychiatric conditions, including ADHD, OCD, and anxiety disorders.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Neuropsychiatric manifestations of Sydenham's chorea: a systematic review

Punukollu

Mushet

Linney³

et al. 2015

Develop Med Child Neuro

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“…A more recent systematic review confirms that all studies of behavioural changes in patients with SC have found an association with OCD 12. In a careful investigation of psychiatric comorbidities in 50 patients with SC, we found that the most frequent psychiatric disorders observed in patients with SC were: major depression (14%); generalised anxiety disorder (16%), social phobia (24%) and OCD (24%) 13. Migraine is more commonly diagnosed in patients with SC than in matched controls 14.…”

Section: Sydenham's Choreasupporting

confidence: 73%

Autoimmune choreas

Cardoso

2016

J Neurol Neurosurg Psychiatry

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Chorea, a movement disorder characterised by a continuous flow of unpredictable muscle contractions, has a myriad of genetic and non-genetic causes. Although autoimmune processes are rare aetiology of chorea, they are relevant both for researchers and clinicians. The aim of this article is to provide a review of the epidemiology, clinical and laboratory features, pathogenesis and management of the most common autoimmune causes of chorea. Emphasis is given particularly to Sydenham's chorea, systemic lupus erythematosus, primary antiphospolipid antibody syndrome, paraneoplastic chorea and anti--methyl-d-aspartate receptor encephalitis.

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“…43 Sydenham chorea (SC) is a poststreptococcal autoimmune neuropsychiatric syndrome, and although most patients improve, many can be left with some residual chorea or psychiatric predisposition. 44,45 Although not a standard of care, it is our practice to use one course of intravenous corticosteroid and immunoglobulin in SC, and there is some support for this in the literature. 46,47 Although symptomatic medications can reduce the symptoms of immune-mediated movement disorders, we believe disease-modifying immunotherapy should be the mainstay of treatment ( Table 2).…”

Section: Immune-mediated Disordersmentioning

confidence: 99%

Current therapies and therapeutic decision making for childhood‐onset movement disorders

2019

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Movement disorders differ in children to adults. First, neurodevelopmental movement disorders such as tics and stereotypies are more prevalent than parkinsonism, and second, there is a genomic revolution which is now explaining many early‐onset dystonic syndromes. We outline an approach to children with movement disorders starting with defining the movement phenomenology, determining the level of functional impairment due to abnormal movements, and screening for comorbid psychiatric conditions and cognitive impairments which often contribute more to disability than the movements themselves. The rapid improvement in our understanding of the etiology of movement disorders has resulted in an increasing focus on precision medicine, targeting treatable conditions and defining modifiable disease processes. We profile some of the key disease‐modifying therapies in metabolic, neurotransmitter, inflammatory, and autoimmune conditions and the increasing focus on gene or cellular therapies. When no disease‐modifying therapies are possible, symptomatic therapies are often all that is available. These classically target dopaminergic, cholinergic, alpha‐adrenergic, or GABAergic neurochemistry. Increasing interest in neuromodulation has highlighted that some clinical syndromes respond better to DBS, and further highlights the importance of “disease‐specific” therapies with a future focus on individualized therapies according to the genomic findings or disease pathways that are disrupted. We summarize some pragmatic applications of symptomatic therapies, neuromodulation techniques, and some rehabilitative interventions and provide a contemporary overview of treatment in childhood‐onset movement disorders. © 2019 International Parkinson and Movement Disorder Society

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Psychiatric disorders in persistent and remitted Sydenham's chorea

Cited by 31 publications

References 12 publications

Neuropsychiatric manifestations of Sydenham's chorea: a systematic review

Neuropsychiatric manifestations of Sydenham's chorea: a systematic review

Autoimmune choreas

Current therapies and therapeutic decision making for childhood‐onset movement disorders

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