Psychiatric Disorders in Female Psychosexual Disorders—A Nationwide, Cohort Study in Taiwan

Abstract

Background: We aimed to investigate whether females with psychosexual disorders (PSD) were associated with the risk of affective and other psychiatric disorders. Methods: A total of 2,240 enrolled individuals, with 560 PSD patients and 1,680 non-PSD subjects (1:3) matched for age and index year, from the Longitudinal Health Insurance Database, retrieved from the National Health Insurance Research Database, between 2000-2015 in Taiwan. The multivariate Cox regression model was used to compare the risk of developing psychiatric disorders during the 15 years of follow-up. Results: There were 98 in the PSD cohort (3444.66 per 100,000 person-year) and 119 in the non-PSD cohort (736.07 per 100,000 person-year) that developed psychiatric disorders. The multivariate Cox regression model revealed that, after the adjustment of age, monthly income, urbanization level, geographic region, and comorbidities, the adjusted hazard ratio (HR) was 9.848 (95% CI= 7.298 — 13.291, p < 0.001). Sexual dysfunctions (adjusted HR = 6.448), paraphilia (adjusted HR = 33.366), and gender identity disorders (adjusted HR = 12.286) were associated with the overall psychiatric disorders. Conclusions: Female patients with PSD were associated with the risk of psychiatric disorders. This finding could be a refiner for clinicians about the mental health problems in the PSD patients.