Psychiatric disorders in China: strengths and challenges of contemporary research and clinical services

Chang, Xiao; Gong, Qiyong; Li, Chunbo; Yue, Weihua; Yu, Xinguang; Yao, Shuqiao; Feng, Jianfeng

doi:10.1017/s0033291721002816

Cited by 7 publications

(4 citation statements)

References 111 publications

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“…1 B). To further validate this observation, we also estimated the immune cell proportions in other three independent bulk blood transcriptomic datasets (i.e., ANM1, ANM2 [ 47 ], and ZIB [ 75 ]) using three alternative computational tools (i.e., quanTIseq [ 59 ], CIBERSORT [ 60 ], and MCP-counter [ 61 ]). As expected, we found a significantly higher NLR in AD than in NC in most of the datasets when using different computational tools except for ANM2 dataset under CIBERSORT (Fig.…”

Section: Resultsmentioning

confidence: 99%

Cellular transcriptional alterations of peripheral blood in Alzheimer’s disease

Song

Yang²,

Guo³

et al. 2022

BMC Med

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Background Alzheimer’s disease (AD), a progressive neurodegenerative disease, is the most common cause of dementia worldwide. Accumulating data support the contributions of the peripheral immune system in AD pathogenesis. However, there is a lack of comprehensive understanding about the molecular characteristics of peripheral immune cells in AD. Methods To explore the alterations of cellular composition and the alterations of intrinsic expression of individual cell types in peripheral blood, we performed cellular deconvolution in a large-scale bulk blood expression cohort and identified cell-intrinsic differentially expressed genes in individual cell types with adjusting for cellular proportion. Results We detected a significant increase and decrease in the proportion of neutrophils and B lymphocytes in AD blood, respectively, which had a robust replicability across other three AD cohorts, as well as using alternative algorithms. The differentially expressed genes in AD neutrophils were enriched for some AD-associated pathways, such as ATP metabolic process and mitochondrion organization. We also found a significant enrichment of protein-protein interaction network modules of leukocyte cell-cell activation, mitochondrion organization, and cytokine-mediated signaling pathway in neutrophils for AD risk genes including CD33 and IL1B. Both changes in cellular composition and expression levels of specific genes were significantly associated with the clinical and pathological alterations. A similar pattern of perturbations on the cellular proportion and gene expression levels of neutrophils could be also observed in mild cognitive impairment (MCI). Moreover, we noticed an elevation of neutrophil abundance in the AD brains. Conclusions We revealed the landscape of molecular perturbations at the cellular level for AD. These alterations highlight the putative roles of neutrophils in AD pathobiology.

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Section: Resultsmentioning

confidence: 99%

Cellular transcriptional alterations of peripheral blood in Alzheimer’s disease

Song

Yang²,

Guo³

et al. 2022

BMC Med

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“…For example, in the Zhangjiang International Brain BioBank (Shanghai) alone, neuroimaging/neurocognitive/environmental/gut microbiota data and corresponding blood samples have been collected from 7500 healthy subjects and 4400 patients with various mental disorders. 35 Lastly, it should be noted that some other countries and organisations have also launched brain projects after 2010 (table 2), such as Korea (2016), 36 the UK (2010), 37 Canada (2017), 38 Israel (2011), 39 Australia (2016) 40 and the International Brain Laboratory (2016, inte rnat iona lbra inlab. com), constituting a worldwide array of brain science.…”

Section: The Array Of National Brain Projectsmentioning

confidence: 99%

“…In addition, physiological data from different body parts have been comprehensively gathered. For example, in the Zhangjiang International Brain BioBank (Shanghai) alone, neuroimaging/neurocognitive/environmental/gut microbiota data and corresponding blood samples have been collected from 7500 healthy subjects and 4400 patients with various mental disorders 35…”

Section: The Array Of National Brain Projectsmentioning

confidence: 99%

Decoding psychosis: from national genome project to national brain project

Sun

Shi

et al. 2022

Gen Psych

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The mind has puzzled humans for centuries, and its disorders, such as psychoses, have caused tremendous difficulties. However, relatively recent biotechnological breakthroughs, such as DNA technology and neuroimaging, have empowered scientists to explore the more fundamental aspects of psychosis. From searching for psychosis-causing genes to imaging the depths of the brain, scientists worldwide seek novel methods to understand the mind and the causes of its disorders. This article will briefly review the history of understanding and managing psychosis and the main findings of modern genetic research and then attempt to stimulate thought for decoding the biological mechanisms of psychosis in the present era of brain science.

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“…China accounts for 17% of the global disease burden attributable to mental, neurological, and substance use disorders, constituting 10% of its national disease burden (Baxter et al, 2016). As a country undergoing profound societal change, China faces growing challenges to reduce the disease burden caused by mental disorders (Chang et al, 2021). Over the past decades, the focus of the deinstitutionalization movement has shifted from mental hospitals to community mental health centers (Bhugra et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of enhancing contact model on reducing family caregiving burden and improving psychological wellbeing among caregivers of persons with schizophrenia in rural China

et al. 2022

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Background It is unclear whether the enhancing contact model (ECM) intervention is effective in reducing family caregiving burden and improving hope and quality of life (QOL) among family caregivers of persons with schizophrenia (FCPWS). Methods We conducted a cluster randomized controlled trial in FCPWS in eight rural townships in Xinjin, Chengdu, China. In total, 253 FCPWS were randomly allocated to the ECM, psychoeducational family intervention (PFI), or treatment as usual (TAU) group. FCPWS in three groups were assessed caregiving burden, QOL and state of hope at baseline (T0), post-intervention (T1), 3-month (T2), and 9-month (T3) follow-up, respectively. Results Compared with participants in the TAU group, participants in the ECM group had statistically significantly lower caregiving burden scores both at T1 and T2 (p = 0.0059 and 0.0257, respectively). Compared with participants in the TAU group, participants in the PFI group had statistically significantly higher QOL scores in T1 (p = 0.0406), while participants in the ECM group had statistically significantly higher QOL scores in T3 (p = 0.0240). Participants in both ECM and PFI groups had statistically significantly higher hope scores than those in the TAU group at T1 (p = 0.0160 and 0.0486, respectively). Conclusions This is the first study to explore the effectiveness of ECM on reducing family caregiving burden and improving hope and QOL in rural China. The results indicate the ECM intervention, a comprehensive and multifaceted intervention, is more effective than the PFI in various aspects of mental wellbeing among FCPWS. Future research needs to confirm ECM's effectiveness in various population.

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Psychiatric disorders in China: strengths and challenges of contemporary research and clinical services

Cited by 7 publications

References 111 publications

Cellular transcriptional alterations of peripheral blood in Alzheimer’s disease

Cellular transcriptional alterations of peripheral blood in Alzheimer’s disease

Decoding psychosis: from national genome project to national brain project

Effectiveness of enhancing contact model on reducing family caregiving burden and improving psychological wellbeing among caregivers of persons with schizophrenia in rural China

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