Psychiatric disorders in adult‐onset focal dystonia: A case‐control study

Fabbrini, Giovanni; Berardelli, Isabella; Moretti, Giuliano; Pasquini, Massimo; Bloise, Maria; Colosimo, Carlo; Biondi, Massimo; Berardelli, Alfredo

doi:10.1002/mds.22983

Cited by 169 publications

(169 citation statements)

References 25 publications

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“…The pattern of expression of these psychiatric maladies—present in nonmanifesting carriers and lacking correlation with motor severity—suggests that they are part of dystonia's endophenotype 70, 71, 72, 73. Recent case‐controlled research shows an increased prevalence of depression, anxiety, and obsessive‐compulsive traits in most of the adult‐onset idiopathic focal dystonias, confirming older observations 74, 75, 76, 77…”

Section: Modern Dystonia's Unresolved Historysupporting

confidence: 56%

A History of Dystonia: Ancient to Modern

Newby

Thorpe

Kempster

et al. 2017

Movement Disord Clin Pract

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Before 1911, when Hermann Oppenheim introduced the term dystonia, this movement disorder lacked a unifying descriptor. While words like epilepsy, apoplexy, and palsy have had their meanings since antiquity, references to dystonia are much harder to identify in historical documents. Torticollis is an exception, although there is difficulty distinguishing dystonic torticollis from congenital muscular torticollis. There are, nevertheless, possible representations of dystonia in literature and visual art from the pre‐modern world. Eighteenth century systematic nosologists such as Linnaeus, de Sauvages, and Cullen had attempted to classify some spasmodic conditions, including torticollis. But only after Charcot's contributions to clinical neuroscience were the various forms of generalized and focal dystonia clearly delineated. They were categorized as névroses: Charcot's term for conditions without an identifiable neuroanatomical cause. For a time thereafter, psychoanalytic models of dystonia based on Freud's ideas about unconscious conflicts transduced into physical symptoms were ascendant, although there was always a dissenting “organic” school. With the rise of subspecialization in movement disorders during the 1970s, the pendulum swung strongly back toward organic causation. David Marsden's clinical and electrophysiological research on the adult‐onset focal dystonias was particularly important in establishing a physical basis for these disorders. We are still in a period of “living history” of dystonia, with much yet to be understood about pathophysiology. Rigidly dualistic models have crumbled in the face of evidence of electrophysiological and psychopathological overlap between organic and functional dystonia. More flexible biopsychosocial frameworks may address the demand for new diagnostic and therapeutic rationales.

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Section: Modern Dystonia's Unresolved Historysupporting

confidence: 56%

A History of Dystonia: Ancient to Modern

Newby

Thorpe

Kempster

et al. 2017

Movement Disord Clin Pract

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“…High frequency of depression and anxiety observed in our BSP and CD patients resembles the results of some other studies (Fabbrini et al., 2010; Gundel et al., 2003; Lencer et al., 2009). Muller et al.…”

Section: Discussionmentioning

confidence: 99%

Nonmotor symptoms in primary adult‐onset cervical dystonia and blepharospasm

et al. 2016

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BackgroundThe nature and frequency of nonmotor symptoms in primary adult‐onset cervical dystonia (CD) and blepharospasm (BSP) patients in Chinese populations remain unknown.MethodsHamilton's Depression Scale (HAMD), Hamilton's Anxiety Scale (HAMA), Addenbrooke's Cognitive Examination Revised (ACE‐R), Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale were used to evaluate NMS in 120 patients with primary focal adult‐onset dystonia (60 with BSP and 60 with CD) and 60 age‐, sex‐, and education level‐ matched healthy controls (HCs). Motor symptoms of BSP and CD patients were evaluated by Jankovic rating scale and Toronto Western Spasmodic Torticollis Rating Scale‐severity scale separately.ResultsTwenty patients had depression, and 29 patients had anxiety. The mean HAMD and HAMA scores were significantly higher in patient groups. Thirty‐six patients had cognitive decline based on the cut‐off score of 75. The total score and scores of each domain of ACE‐R were significantly lower in patient groups than that in HCs. Quality of sleep was impaired in patient groups, and patients with CD had worse quality of sleep than patients with BSP. Thirty‐three BSP patients and 43 CD patients suffered from sleep disorder separately. The frequency of excessive daytime sleepiness did not differ between patients and HCs. No significant correlation was found between NMS and motor severity in the two forms of dystonia.ConclusionsCurrent study suggests that NMS are prevalent in Chinese CD and BSP patients, and the motor severity of dystonia did not contribute to the severity of nonmotor symptoms. Assessment of nonmotor symptoms should be considered in clinical management of focal dystonia

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“…Так, в одном из исследований из 89 пациентов с фокальной дистонией 57,3% страдали различ-ными психиатрическими заболеваниями, которые сформи-ровались в среднем за 18,4 ± 13,9 года до начала дистонии [17]. В исследовании, проведенном Heiman с соавт.…”

Section: эмоциональные расстройстваunclassified

Focal Dystonias: Non-Motor Symptoms and Comorbidities

Толмачёва¹

2017

Med. sov.

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Дистония является распространенным экстрапирамидным заболеванием. Для нее характерны как моторные, так и немоторные проявления, к которым относятся боль, сенсорные нарушения, избыточная двигательная активность. Обсуждается вклад тревож-ных и депрессивных расстройств, нарушений сна в течение фокальной дистонии. Нередко именно немоторные проявления являются начальными симптомами дистонии. В ряде случаев немоторные проявления можно выделить в самостоятельные заболевания, которые сопутствуют дистоническому гиперкинезу и способствуют ухудшению качества жизни таких больных. Лечение немоторных симптомов позволит повысить эффективность терапии дистонии, а также повлиять на течение заболевания.Ключевые слова: дистония, немоторные симптомы, коморбидность, лечение. V.A. TOLMACHYOVA, PhD in medicine, Sechenov First Moscow State Medical University FOCAL DYSTONIAS: NON-MOTOR SYMPTOMS AND COMORBIDITIESDystonia is a common extrapyramidal disease. It is characterized by both motor and non-motor manifestations, which include pain, sensory disorders and excessive physical activity. The contribution of disturbing and depressed disorders, sleep disorders during the focal dystonia has been discussed. It is often the non-motor manifestations that are the initial symptoms of dystonia. In some cases, unmotorized manifestations can be isolated diseases that accompany dystonic hyperkinesis and contribute to the deterioration of the quality of life of such patients. Treatment of nonmotor symptoms will improve the effectiveness of dystonia therapy as well as affect the course of the disease.

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Psychiatric disorders in adult‐onset focal dystonia: A case‐control study

Cited by 169 publications

References 25 publications

A History of Dystonia: Ancient to Modern

A History of Dystonia: Ancient to Modern

Nonmotor symptoms in primary adult‐onset cervical dystonia and blepharospasm

Focal Dystonias: Non-Motor Symptoms and Comorbidities

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