Psychiatric disorders, body mass index and C-reactive protein in dialysis patients

Preljevic, Valjbona; Østhus, Tone Brit Hortemo; Sandvik, Leiv; Bringager, Christine Bull; Opjordsmoen, Stein; Nordhus, Inger Hilde; Os, Ingrid; Dammen, Toril

doi:10.1016/j.genhosppsych.2011.06.010

Cited by 28 publications

(24 citation statements)

References 108 publications

(175 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…30 A relationship between BMI, serum albumin, and DS has been previously described. 31,32 However, the present study does not corroborate those findings. Our results only suggest a protective effect of lean body mass against all-cause mortality.…”

contrasting

confidence: 99%

Depression, quality of life, and body composition in patients with end-stage renal disease: a cohort study

Barros

Costa

Mottin

et al. 2016

Rev. Bras. Psiquiatr.

View full text Add to dashboard Cite

Objective: To prospectively evaluate depressive symptoms, nutritional status, and quality of life (QoL) and search for possible associations in patients with end-stage renal disease undergoing hemodialysis. Methods: A cohort study of 104 adult patients with end-stage renal disease undergoing hemodialysis was conducted. Anthropometric, clinical, and biochemical variables were evaluated after a midweek hemodialysis session. The participants' body composition was assessed by direct segmental multifrequency bioimpedance analysis. The WHOQOL-Bref questionnaire was used to evaluate QoL. Participants were separated into two groups -depressive symptoms and no depressive symptoms -at inclusion and evaluated annually for 2 years thereafter using the Beck Depression Inventory. Survival analysis used the Kaplan-Meier method and Cox regression analysis for the goodness of fit of associated factors. All-cause mortality was the outcome of interest. Results: Participants' mean age was 55.3615.6 years, 60% were male, and the median time on hemodialysis was 17.5 (8.0-36.8) months. Thirty-two patients had depressive symptoms and a significantly lower QoL compared with the 72 patients in the no depressive symptoms group. The fitted outcome model showed that lean body mass had a protective effect against all-cause mortality (hazard ratio [HR] = 0.89; 95%CI 0.80-0.99; p = 0.038). Conclusion: Depressive symptoms were highly prevalent in the cohort, and correlated with the physical and psychological components of the QoL life questionnaire, as well as with C-reactive protein and phosphorus levels. Lean body mass was protective for the assessed outcome.

show abstract

contrasting

confidence: 99%

Depression, quality of life, and body composition in patients with end-stage renal disease: a cohort study

Barros

Costa

Mottin

et al. 2016

Rev. Bras. Psiquiatr.

View full text Add to dashboard Cite

show abstract

“…In a study by Preljevic et al, dialysis patients with a CRP level !6 mmol/L were found to have four times higher odds of having depressive and/or anxiety disorder. 33 Also, Dogan et al reported a significant correlation between Hamilton Anxiety Scale (HAMA) scores and CRP. 34 Although these findings are in concordance with our results, further studies are needed to clarify the potential relation between inflammation and anxiety specifically for PD patients.…”

Section: Discussionmentioning

confidence: 99%

Serum apelin is associated with affective disorders in peritoneal dialysis patients

et al. 2016

View full text Add to dashboard Cite

Objective: Depression and anxiety are prevalent affective disorders in peritoneal dialysis (PD) patients. Recent research has proposed a potential role of apelinergic system in pathogenesis of depression. The present study aimed to evaluate the frequency of depression and anxiety and their potential relation with serum apelin levels among PD patients. Methods: A total of 40 PD patients were enrolled into the study. Depressive symptoms and anxiety were assessed with the Beck's Depression Inventory and the Beck's Anxiety Inventory. Serum apelin-12 levels were measured by immunoenzymatic assays using commercially available ELISA kit for standard human apelin. Results: Of the patients, 16 (40%) had depression, 20 (50%) had anxiety. The patients with depression and anxiety had a significantly longer time on dialysis (p < 0.001 for both), significantly higher serum apelin (p < 0.001 for both) and C-reactive protein levels (p < 0.001 for both) than those without depression and anxiety. In multivariate analysis, serum apelin was the only parameter associated independently with depression and anxiety scores. Conclusions: A substantial number of PD patients had depression and anxiety. Increased levels of serum apelin may constitute a significant independent predictor of development of depression and anxiety in PD patients. ARTICLE HISTORY

show abstract

“…Three general routes are suggested in this regard; the effect of depression on inflammation; the effect inflammation on depression; and also the bidirectional relationship. [1] The studies on patients with coronary artery disease,[26] dialysis patients[2728] and patients with fibromyalgia,[29] have indicated a relationship between anxiety/depression severity and serum levels of CRP. In patients with symptoms of obstructive sleep apnea, serum level of CRP has been significantly associated with anxiety and depression severity, and patients with combined mood disorder had the highest CRP levels.…”

Section: Discussionmentioning

confidence: 99%

Is there any association of personality traits with vascular endothelial function or systemic inflammation?

et al. 2014

View full text Add to dashboard Cite

Background:Evidences showed association of some personality traits with increased risk of cardiovascular diseases, but mediated mechanisms are not entirely described. In this study, we investigated the association of different personality traits with systemic inflammation and endothelial function as probable mediators.Methods:This cross-sectional study was conducted in 2011 on 40-60 years old employees of an industrial company located in Isfahan city (central Iran). Participants were selected through simple random sampling. Personality types were evaluated using the neuroticism-extroversion-openness personality inventory and systemic inflammatory status was determined with high sensitive C-reactive protein (hs-CRP) level. To evaluate endothelial function flow mediated dilation (FMD) were measured. The obtained data were analyzed with univariate correlation and multiple linear regression tests.Results:A total of 254 cases with mean age of 51.4 ± 6.1 years were evaluated. There was no significant relationship between hs-CRP level and FMD with the personality traits in univariate analysis. In multivariate analysis, no association was found between the scores of personality traits and FMD with controlling the factors such as age, body mass index dyslipidemia, hypertension and diabetes. Only there was an inverse association between conscientiousness score and hs-CRP (β = −0.241, P = 0.013).Conclusions:In our population who were the employees of an industrial company, no relationship was found between specific personality trait and endothelial dysfunction. However, we found that the personality trait of responsibility (conscientiousness) is negatively associated with inflammation. Further multi-center studies and also cohort studies are recommended in this regard.

show abstract

Psychiatric disorders, body mass index and C-reactive protein in dialysis patients

Cited by 28 publications

References 108 publications

Depression, quality of life, and body composition in patients with end-stage renal disease: a cohort study

Depression, quality of life, and body composition in patients with end-stage renal disease: a cohort study

Serum apelin is associated with affective disorders in peritoneal dialysis patients

Is there any association of personality traits with vascular endothelial function or systemic inflammation?

Contact Info

Product

Resources

About