Psychiatric disorders and symptoms severity in preschool children with atopic eczema

Çatal, Ferhat; Topal, Erdem; Soylu, Nusret; Özcan, Özlem; Celiksoy, Mehmet Halil; Babayiğit, Arzu; Karakoc, Habib; Erge, Duygu; Sancak, Recep

doi:10.1016/j.aller.2015.04.006

Cited by 29 publications

(42 citation statements)

References 24 publications

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“…Two of these studies found a link between food allergies and neuropsychiatric conditions such as depression, anxiety, and ADHD [34,38], while others looked at immune dysregulation [33], asthma medications [37], and atopic eczema [35]. Our study supports the hypothesis that, in children diagnosed with ADHD, there is a subset of children who also suffer from atopic disease.…”

Section: Discussionsupporting

confidence: 80%

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Attention Deficit Disorder and Allergic Rhinitis - Are They Related?

Melamed¹

2016

Int J Aller Medcations

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The association between ADHD and allergy remains controversial. Our previous findings suggest that nerve growth factor may link the nervous and immune systems. The primary objective of this study was to determine if a combination of cetirizine + methylphenidate is effective in children with comorbid ADHD and allergic rhinitis. We also examined the role of nerve growth factor in these comorbidities. Our randomized, double-blind, placebo-controlled, crossover study enrolled 38 children diagnosed with comorbid ADHD and allergy using cetirizine ( = 12), sustained-release methylphenidate ( = 12), or cetirizine + methylphenidate ( = 14). Endpoints compared baseline to posttreatment evaluations for allergic rhinitis and ADHD scores. Serum nerve growth factor levels were measured using ELISA. For allergy endpoints, combination therapy produced results superior to individual therapy. For ADHD, similar scores were achieved for individual therapy; however, combination therapy resulted in improved scores. Nerve growth factor levels were downregulated following this trend. We conclude that ADHD and allergic rhinitis may have common mechanism and represent a comorbid condition that links the nervous system to the immune system. Further studies are needed.

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Section: Discussionsupporting

confidence: 80%

“…A number of studies have suggested a link between allergies and ADHD [34][35][36][37][38]. Two of these studies found a link between food allergies and neuropsychiatric conditions such as depression, anxiety, and ADHD [34,38], while others looked at immune dysregulation [33], asthma medications [37], and atopic eczema [35].…”

Section: Discussionmentioning

confidence: 99%

Attention Deficit Disorder and Allergic Rhinitis - Are They Related?

Melamed¹

2016

Int J Aller Medcations

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“…Although the results have been inconsistent, most studies have pointed to a positive association between AD and ADHD. [1,9,18,25,26,31] In an early study published in 1993, McGee et al [18] reported no significant association between ADHD behavior and a history of allergic disorders and that a diagnosis of ADHD was also not related to a positive skin test or serum IgE levels. In addition, Shyru et al [20] showed that bronchial asthma and allergic rhinitis, but not AD, were the risk factors for ADHD.…”

Section: Discussionmentioning

confidence: 99%

“…[1] It is well known that patients with AD have a higher risk of developing other allergic diseases. [7,22–24] The presence of a correlation between ADHD/ASD and AD is a strong possibility, [25] but not all investigators agree with this conclusion (Table 1). [1,9,15,18–21,25–33] Reviewing the latest reports, most of the studies find in favor of a positive association between AD and ADHD/ASD in children, but investigations targeting longitudinal associations are still not being carried out in sufficient numbers.…”

Section: Introductionmentioning

confidence: 99%

Longitudinal association between early atopic dermatitis and subsequent attention-deficit or autistic disorder

et al. 2016

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Atopic dermatitis (AD) is one of the common allergic diseases in children. The presence of allergic diseases was found to have association with the risk of developing attention-deficit hyperactivity disorder (ADHD) or autistic spectrum disorder (ASD) in children, but it is still inconclusive. This study was to investigate the longitudinal relationship between AD developed during toddlerhood and subsequent development of ADHD or ASD in later childhood. Toddlers born between 1998 and 2008 and diagnosed with AD at the age younger than 3 years and older than 1 month were retrieved from Taiwan's National Health Insurance Research Database. Age- and gender-matched toddlers with no lifetime AD were enrolled as the control group. All enrolled toddlers were followed until 2011 to identify the development of ADHD or ASD. Multivariate Cox regression analysis was performed to analyze the hazard ratios (HRs). The risks associated with allergic comorbidities were analyzed. A total of 18,473 toddlers were enrolled into the AD group. The presence of AD significantly increased the risk of developing ADHD (HR = 2.92, 95% confidence interval [CI] = 2.48–3.45) or ASD (HR = 8.90, 95% CI = 4.98–15.92) when aged 3 years or older. Children from the AD group with 3 comorbidities together, namely, allergic rhinitis, allergic conjunctivitis, and asthma, had the greatest risk of developing ADHD and ASD (ADHD: HR = 4.67, 95% CI = 3.81–5.43; ASD: HR = 16.65, 95% CI = 8.63–30.60). In conclusion, toddlers who suffer from AD at the age younger than 3 years are at a higher risk of developing ADHD and ASD during later childhood. Pediatricians taking care of toddlers with AD should have knowledge of this increased risk of developing ADHD and ASD later in life, especially when children have certain comorbidities such as allergic rhinitis, allergic conjunctivitis, and asthma.

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“…AD not only causes various physical issues but also leads to psychological problems; patients experience frequent skin damage and sleep disorder due to extreme pruritus [6] and show depression, anxiety, attention deficit, tiredness, irritable mood, and aggressive behavior [7]. Parents of children with AD must strictly manage AD in daily life, such as consistent skin moisturization, food preparation, and environmental management, as well as general childcare for each stage of the child's growth; therefore, in addition to the pain experienced by the child, the degree of parenting stress is relatively higher than with other diseases [8].…”

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confidence: 99%

Actor and Partner Effects of Parenting Stress and Co-parenting of Parents of Children with Atopic Dermatitis on Marital Conflict: Multiple-group Analysis Based on Mother’s Employment Status

Han

LEE

2019

Preprint

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Objective This study aims to determine the effect of parenting stress and co-parenting on marital conflict and the actor and partner effects of parental variables and to identify the control effect based on the mother's employment status. Method In this study, among all children who participated in the panel study and health questionnaire survey, 161 fathers and 161 mothers raising seven-year-old children recently treated for atopic dermatitis for 12 months were selected as the final study participants. Results The father's parenting stress had an actor and a partner effect on the coparenting, and the mother's parenting stress had an actor and a partner effect on the co-parenting.The father's parenting stress only had an actor effect on the marital conflict(β=.32, p<.001). The father's co-parenting had an actor(β=-.29, p<.001) and a partner effect(β=-.22, p<.001) on the marital conflict, and the mother's co-parenting had an actor(β=-.39, p<.001) and a partner(β=-.19, p<.001) effect on the marital conflict. There were statistically significant differences between two groups in terms of the path coefficient of the father's parenting stress affecting father's marital conflict, path coefficient of the father's co-parenting affecting father's marital conflict, and path coefficient of the mother's co-parenting affecting father's marital conflict Conclusions This study is meaningful in providing basic data for the development of an atopic dermatitis family management program by investigating the actor and partner effects of parenting stress and co-parenting on marital conflict as well as the control effect based on the mother's employment status. BackgroundAtopic dermatitis (AD) is the most prevalent sustained chronic inflammation and pruritic skin disease, affecting many infants and children in industrialized countries [1]. In Korea, according to the Ministry of Health and Welfare's Korea Health Statistics, the prevalence of AD is steadily increasing at 2.4% in 2007, 3.3% in 2010, and 3.8% in 2015[2]. According to a survey on the prevalence of allergic diseases in Korea among 933,000 patients, AD was most prevalent in patients under 12 years with 48.6% followed by 12.7% in those between 13 and 19 years and 11.8% in those in their 20s, showing that patients are more commonly children and adolescents (<12 years) than other age groups [3]. In particular, the symptoms of AD peak between four and six years[4] and often develop into allergic HJW developed a hypothesis, searched the literature, reviewed the relevant articles, analyzed the data, interpreted the findings, and wrote a manuscript. LH developed the hypothesis, reviewed the relevant article, and wrote the manuscript. All authors have read and approved the manuscript.

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Psychiatric disorders and symptoms severity in preschool children with atopic eczema

Abstract: Psychiatric illnesses are frequent in preschool children with atopic eczema.

Cited by 29 publications

References 24 publications

Attention Deficit Disorder and Allergic Rhinitis - Are They Related?

Attention Deficit Disorder and Allergic Rhinitis - Are They Related?

Longitudinal association between early atopic dermatitis and subsequent attention-deficit or autistic disorder

Actor and Partner Effects of Parenting Stress and Co-parenting of Parents of Children with Atopic Dermatitis on Marital Conflict: Multiple-group Analysis Based on Mother’s Employment Status

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