Psychiatric Disorders and Inflammation

Dantzer, Robert

doi:10.1002/9783527692156.ch29

Cited by 4 publications

(3 citation statements)

References 97 publications

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“…Increasingly insightful evidences are mounting in the PNI of bipolar affective disorder, schizophrenia, alcohol use disorder and posttraumatic stress disorder, and to some extent on personality disorders, eating disorders and adjustment disorders, all of which confer substantially elevated risks for SSB ( Too et al., 2019 ). The evidence of immune dysregulation in the pathophysiology across the heterogeneous spectrum of psychiatric disorders ( Dantzer, 2017 ) may also indicate that suicide endophenotype related to immune dysregulation is plausible ( Isung et al., 2014 ). Recently, a large genome-wide association data suggested genetic overlap between C-reactive protein (CRP) and depression, and that upregulated IL-6 signaling could be a potential causal factor for suicidality ( Kappelmann et al., 2020 ).…”

Section: Neuroimmune Dysregulation In Suicide Suicidal Behavior and Associated Conditionsmentioning

confidence: 99%

Psychoneuroimmunology: The new frontier in suicide research

Neupane

2021

Brain, Behavior, & Immunity - Health

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Elucidating complex, multifactorial phenomena like suicide and suicidal behaviors (SSB) require multidisciplinary fields such as Psychoneuroimmunology (PNI). Indeed, our appreciation of the bidirectional communication channels between the brain and the rest of the body with its immune arsenal as the key player has positioned PNI as a promising field of research. We now know that major psychiatric, behavioral, and somatic disorders related to SSB accompany neuroimmune dysregulation. These disorders range from depression, emotional dysregulation, atopy, and epilepsy to certain viral and parasitic infections. By utilizing epidemiological, genetic, microbial, and molecular approaches, the PNI research community has excogitated novel biomarker candidates and pathways in support of SSB risk stratification at individual level. This remarkable progress in just two previous decades shall, if successful, help implement personalized prevention and treatment strategies, using PNI-assisted tools. The aims of this narrative review and opinion piece are to summarize important discoveries concerning the role of neuroimmune activation in SSB and to highlight important future directions for the field. Major caveats of the findings concerning methodological approaches, clinical reality of frequent comorbid psychopathology, and novel molecular targets are presented. Finally, this review calls on the PNI research community for increased attention towards factors that promote resilience to suicide, while accepting “consciousness” under its wing. Thus, PNI represents the new frontier in suicide research. Future breakthroughs in this discipline shall bring us closer to understanding the biological substrates of qualia i.e., subjective, and experiential meanings of life and death.

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Section: Neuroimmune Dysregulation In Suicide Suicidal Behavior and Associated Conditionsmentioning

confidence: 99%

Psychoneuroimmunology: The new frontier in suicide research

Neupane

2021

Brain, Behavior, & Immunity - Health

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“…Inflammation is involved in the pathophysiology of several major psychiatric disorders that are also linked to suicidal behavior, such as mood disorders, schizophrenia and substance use disorders ( Dantzer, 2017 ;Köhler et al, 2017 ;Yuan et al, 2019 ). This observation raises the question of whether these indices of inflammation are also linked to the risk of suicidal behavior (SB) in these disorders.…”

Section: Introductionmentioning

confidence: 99%

Immune-Related Biomarkers and Suicidal Behaviors: A Meta-Analysis

et al. 2022

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“…While short-term alterations in motivated behavior, as in the context of sickness, are often seen as adaptive, chronic alterations in motivational states are generally considered maladaptive, as would be the case with the motivational deficits that are associated with major depressive disorder (MDD). Inflammation can induce depression [7,8]. This depression is mainly apparent in the form of decreased activity, anergia or fatigue, and decreased response to rewards [9,10].…”

Section: Introductionmentioning

confidence: 99%

Inflammation-induced motivational changes: perspective gained by evaluating positive and negative valence systems

Vichaya

Dantzer

2018

Current Opinion in Behavioral Sciences

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Inflammation can profoundly impact motivated behavior, as is the case with inflammation-induced depression. By evaluating objectively measurable basic neurobehavioral processes involved in motivation, recent research indicates that inflammation generally reduces approach motivation and enhances avoidance motivation. Increased effort valuation largely mediates the effects of inflammation on approach motivation. Changes in reward valuation are not uniformly observed in approach motivation. However, inflammation increases the averseness of negative stimuli. Within the context of both approach and avoidance motivation, inflammation appears to enhance the contrast between concurrently presented stimuli. While changes in both approach and avoidance motivation appear to be mediated by midbrain dopaminergic neurotransmission to the ventral striatum, it is unclear if the enhanced contrast is mediated by the same system.

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Psychiatric Disorders and Inflammation

Cited by 4 publications

References 97 publications

Psychoneuroimmunology: The new frontier in suicide research

Psychoneuroimmunology: The new frontier in suicide research

Immune-Related Biomarkers and Suicidal Behaviors: A Meta-Analysis

Inflammation-induced motivational changes: perspective gained by evaluating positive and negative valence systems

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