Psychiatric Disorders and Functioning in Hepatitis B Virus Carriers

Ateşçi, Figen Çulha; Çetin, Banu; Oğuzhanoğlu, Nalan Kalkan; Karadag, Filiz; Turgut, Hüseyin

doi:10.1176/appi.psy.46.2.142

Cited by 40 publications

(50 citation statements)

References 10 publications

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“…The knowledge of HBV related cirrhosis and hepatocelluar carcinoma and insufficient knowledge of the modes of transmission may results in isolation[3]. Consistently with this conception, in this study, the proportion of high stress scores patients was much higher in inadequate educated participants than well-educated subjects (61.5% vs 28.5%), while the proportion of well education was much lower in high stress group than that of the low stress group (20% vs 80%, chi-square 7.912, p = .009).…”

Section: Resultsmentioning

confidence: 99%

“…HBV infection results in approximately 280 thousand deaths per year, caused by chronic hepatitis, cirrhosis, and hepatocellular carcinoma, which are associated with heavy psychological stress, enormous medical-care costs,and emotional and economic burden on those afflicted and/or their families[2]. HBV infection is a major life stressor, with up to 90% of those subjects reporting significant stress since the diagnosis of HBV infection[3]. Accumulating evidence has linked stress to the initiation, course and outcome of liver diseases[4].…”

Section: Introductionmentioning

confidence: 99%

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Psychological Stress Exerts Effects on Pathogenesis of Hepatitis B via Type-1/Type-2 Cytokines Shift toward Type-2 Cytokine Response

Gao²,

et al. 2014

PLoS ONE

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BackgroundPsychological and physical stress has been demonstrated to have an impact on health through modulation of immune function. Despite high prevalence of stress among patients with hepatitis B virus (HBV) infection, little is known about whether and how stress exerts an effect on the course of hepatitis B.MethodsEighty patients with chronic hepatitis B(CHB) completed the Perceived Stress Scale-10(PSS-10) and State-Trait Anxiety Inventory(STAI). Fresh whole blood was subject to flow cytometry for lymphocytes count. Plasma samples frozen at −80°C were thawed for cytokines, alanine aminotransferase (ALT), and virus load. These patients were grouped into high or low perceived stress, state anxiety and trait anxiety groups according to the scale score. Sociodemographic, disease-specific characteristics, lymphocytes count and cytokines were compared.ResultsFirstly, a negative association between ALT and stress (t = −4.308; p = .000), state anxiety (t = −3.085; p = .003) and trait anxiety (t = −4.925; p = .000) were found. As ALT is a surrogate marker of hepatocytes injury, and liver injury is a consequence of immune responses. Next, we tested the relationship between stress/anxiety and lymphocytes. No statistical significance were found with respect to counts of total T cells, CD4+ T cell, CD8+ T cell, NK cell, and B cell count between high and low stress group. Type-2 cytokine interleukin-10 (IL-10) level was significantly higher in high stress group relative to lower counterpart (t = 6.538; p = 0.000), and type-1 cytokine interferon-gamma (IFN-γ) level shown a decreased tendency in high stress group (t = −1.702; p = 0.093). Finally, INF-γ:IL-10 ratio displayed significant decrease in high perceived stress(t = −4.606; p = 0.000), state anxiety(t = −5.126; p = 0.000) and trait anxiety(t = −4.670; p = 0.000) groups relative to low counterparts.ConclusionOur data show stress is not related to the lymphocyte cells count in CHB patients, however, stress induces a shift in the type-1/type-2 cytokine balance towards a type-2 response, which implicated a role of psychological stress in the course of HBV related immune-pathogenesis.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Psychological Stress Exerts Effects on Pathogenesis of Hepatitis B via Type-1/Type-2 Cytokines Shift toward Type-2 Cytokine Response

Gao²,

et al. 2014

PLoS ONE

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“…Increasing data indicate that stress hormones and their corresponding receptors also influence the carcinogenesis and progression of HCC (3,(9)(10)(11)(12)(13)(14)(15)(16). However, there is presently no study investigating the influence of stress hormones in correlation with the ß2-AR on human HCC cells.…”

Section: Discussionmentioning

confidence: 99%

“…The mechanisms that regulate the growth and invasion of HCC cells are poorly understood. Recent studies demonstrated that psychological stress affected the severity of chronic viral hepatitis and cirrhosis (9)(10)(11). Moreover, the expression pattern of ·1-AR and ß2-AR in human HCC was aberrant from that in normal liver tissues (12).…”

Section: Introductionmentioning

confidence: 99%

The mitogenic effectors of isoproterenol in human hepatocellular carcinoma cells

Yuan

Li²,

Li³

et al. 2009

Oncol Rep

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Abstract.Increasing data indicate that stress hormones and their corresponding receptors play an important role in the carcinogenesis and progression of hepatocellular carcinoma (HCC). However, there is presently no study investigating the influence of stress hormones in correlation with ß2-AR on human HCC cells. We examined the expression of ·1-and ß-ARs in human HCC cell line HepG2 and MHCC97H cells in comparison with that in human normal hepatic cell line HL-7702 cells (L-02), and the influence of isoproterenol (ISO) on the growth of these HCC cells using blocking agents in correlation with ß2-AR and its downstream signaling pathways. We found that ·1-AR was down-regulated and ß2-AR was up-regulated in HepG2 and MHCC97H cells. ISO dosedependently promoted the growth of both HepG2 and MHCC97H cells. ISO-induced growth and survival of HCC cells were effectively attenuated by ICI 118551, U0126 and PD153035, but not by H-89 or LY294002. ISO transiently activated MAPK/ERK1/2 in tumor cells which could be blocked either by ICI 118551 or U0126, but not by H-89, LY294002, or PD153035. These findings indicate that ISO mimicking a mitogen promoted the growth of HepG2 and MHCC97H cells via ß2-AR-mediated activation of both MAPK/ERK1/2 dependent and independent signaling pathways, and ISO activated MAPK/ERK1/2 by an EGFRindependent mechanism.

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“…Além disso, há a preocupação com a contaminação de seus parentes. Neste cenário, ocorrem alta ansiedade e depressão, contribuindo para uma piora na qualidade de vida desses pacientes [23].…”

Section: Instrumentos De Avaliação Da Qvrsunclassified

Impacto do diagnóstico das hepatites B e C na qualidade de vida em doadores voluntários de sangue

Ferreira¹

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Psychiatric Disorders and Functioning in Hepatitis B Virus Carriers

Cited by 40 publications

References 10 publications

Psychological Stress Exerts Effects on Pathogenesis of Hepatitis B via Type-1/Type-2 Cytokines Shift toward Type-2 Cytokine Response

Psychological Stress Exerts Effects on Pathogenesis of Hepatitis B via Type-1/Type-2 Cytokines Shift toward Type-2 Cytokine Response

The mitogenic effectors of isoproterenol in human hepatocellular carcinoma cells

Impacto do diagnóstico das hepatites B e C na qualidade de vida em doadores voluntários de sangue

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