Psychiatric Disorders among Patients Undergoing Hemodialysis Therapy

Fukunishi, Isao; Kitaoka, Tateki; Shirai, Tetsuo; Kino, Kyoko; Kanematsu, Emiko; Sato, Yoshikazu

doi:10.1159/000058418

Cited by 112 publications

(80 citation statements)

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“…Individuals with CKD have an increased risk for stroke (20), an established risk factor for cognitive impairment and dementia in the general population (21). In previous studies, CKD and ESRD were more strongly associated with vascular dementia than Alzheimer's dementia (1,4), suggesting that an increased burden of cerebrovascular disease may explain the association between CKD and dementia. In this study, adjustment for incident stroke only modestly attenuated the elevated risk for cognitive impairment for participants with an eGFR Ͻ45 ml/min per 1.73 m 2 and did not change the effect estimates for those with an eGFR 45 to 60 ml/min per 1.73 m 2 , suggesting that factors other than the severity of cerebrovascular disease are involved in the pathogenesis of cognitive impairment in CKD.…”

Section: Discussionmentioning

confidence: 99%

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Chronic Kidney Disease and Cognitive Impairment in the Elderly

Kurella¹,

Chertow²,

Fried³

et al. 2005

Journal of the American Society of Nephrology

418

376

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T he prevalence of cognitive impairment and dementia in ESRD is more than double that of the general population (1-3). However, the reasons for this high rate remain uncertain. Specifically, it is not known whether cognitive impairment is mediated by the direct effects of uremia, per se, or is attributable to a high prevalence of predisposing risk factors among individuals with ESRD and side effects of the hemodialysis treatment. Recent studies suggest that chronic kidney disease (CKD) may also be a risk factor for cognitive impairment (4 -6). Many of the factors that have been proposed as mediators of cognitive impairment in ESRD, such as anemia and inflammation, may be present in individuals with earlier stages of CKD (7,8).CKD has been associated with an increased risk for dementia in elderly individuals (4) and with poorer performance on tests of global cognitive function, executive function, language, and memory (5,6). However, previous studies were conducted in mostly white populations and did not explore several hypothesized mediators of impairment, such as anemia and inflammation. Moreover, no studies have examined the association between CKD and performance on serial cognitive function tests, and only one study stratified analyses by the severity of CKD (6). The goals of this study were to determine the strength of the association between CKD and cognitive function in a biracial cohort of community-dwelling elderly and to explore potential mediators of cognitive impairment and whether these extinguish or otherwise modify the association between CKD and cognitive impairment. We hypothesized that CKD would be associated with cognitive impairment in cross-sectional and longitudinal analyses and that the association would be "dose (severity)-dependent" and independent of established risk factors for cognitive impairment, such as age, low educational attainment, diabetes, hypertension, and other cardiovascular disease risk factors.

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Section: Discussionmentioning

confidence: 99%

“…T he prevalence of cognitive impairment and dementia in ESRD is more than double that of the general population (1)(2)(3). However, the reasons for this high rate remain uncertain.…”

mentioning

confidence: 99%

Chronic Kidney Disease and Cognitive Impairment in the Elderly

Kurella¹,

Chertow²,

Fried³

et al. 2005

Journal of the American Society of Nephrology

418

376

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“…I noen få har man også inkludert pasienter i peritonealdialyse. Et fåtall av studiene har kontrollgrupper, og kun i to av studiene på dialysepasienter har man fulgt kognitiv funksjon over tid (5,6).…”

Section: Forekomst Av Kognitiv Sviktunclassified

“…De viktigste nyere studiene (gjort etter 1995, med antall pasienter ≥ 30 og med gjennomsnittsalder på pasientene ≥ 55 år) er vist i tabell 1 (5,(7)(8)(9)(10)(11).…”

Section: Forekomst Av Kognitiv Sviktunclassified

Kognitiv svikt ved terminal nyresykdom

Sæle

Sønnesyn²,

Svarstad³

et al. 2009

Tidsskriftet

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“…Indeed, several studies have reported end-stage renal disease as a predisposing factor for dementia [1,2]. This high burden is said to be poorly recognized by nephrologists who are the primary physicians caring for patients with CKD [3].…”

Section: Introductionmentioning

confidence: 99%

Predictors of Cognitive Dysfunction among Patients with Moderate to Severe Chronic Kidney Disease

Williams¹,

Oparah²,

Ameh³

2017

Recent Advances in Biology and Medicine

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Cognitive dysfunction including dementia is a common complication of chronic kidney disease (CKD) that has just been recently appreciated. It has negative outcomes in the management of patients with CKD. This study explored the possible biochemical and clinical features of patients with CKD that can predict the occurrence of cognitive impairment in patients with moderate to severe CKD. We evaluate patients with stages 3-5 CKD for the occurrence and predictors of cognitive impairment. Multiple areas of cognitive function were tested in this single-center study using Community Screening Interview for Dementia (CSID) and Trial-Making Test A (TMTA)/Trial-Making Test B (TMTB). Cognitive impairment was correlated with patients' routine biochemical, hematological, and selected clinical parameters. We observed a negative correlation between cognitive impairment and patient's serum calcium (r 5 0.240; p 5 0.033) and estimated Glomerular filtration rate (eGFR) (r 5 0.379; p 5 0.0006). Therefore, eGFR is an accurate predictor of cognitive dysfunction in patients with moderate to severe CKD. Early evaluation of cognitive function in CKD is indeed advised for optimal outcome in the management of patients with CKD.

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Psychiatric Disorders among Patients Undergoing Hemodialysis Therapy

Cited by 112 publications

References 1 publication

Chronic Kidney Disease and Cognitive Impairment in the Elderly

Chronic Kidney Disease and Cognitive Impairment in the Elderly

Kognitiv svikt ved terminal nyresykdom

Predictors of Cognitive Dysfunction among Patients with Moderate to Severe Chronic Kidney Disease

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