Psychiatric Diagnosis, Activation, and Radioactive Iodine Uptake

Chlorpromazine‐procyclidine and imipramine: Effects on thyroid function in psychiatric patients

“…The mean value for men was 48. 4 The effect of treatment with placebo, imipramine, and chlorpromazineprocyclidine is presented in Table II, along with analysis of covariance comparing the drug treatments with placebo. The only major changes were a decrease in renal clearance of iodide and an increase in 24 hour 131 1 uptake and a thyroid 3 following treatment with chlorpromazine-procyclidine.…”

“…4 It has previously been suggested by us that the variability in change in thyroid measures following drug treatment might represent a method of population differentiation. Our failure to find any correlation between change scores and population determinants, including diagnosis, calls for further efforts at detecting subpopulations by use of more refined methods and larger samples.…”