Psychiatric Diagnoses of Treatment-Seeking Cocaine Abusers

Rounsaville, Bruce J.; Anton, Susan F.; Carroll, Kathleen M.; Budde, Douglas; Prusoff, Brigitte A.; Gawin, Frank H.

doi:10.1001/archpsyc.1991.01810250045005

Cited by 578 publications

(291 citation statements)

References 43 publications

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“…The rate of reported childhood ADHD among our patient group (22%) falls within the reported range 12 to 34% (cf. Rounsaville et al, 1991). Thus, it is likely that our sample of cocaine-dependent participants was derived from a group that is representative of the larger population of those in treatment for cocaine dependence (c.f.…”

Section: Discussionmentioning

confidence: 99%

Attentional deficits in cocaine-dependent patients: Converging behavioral and electrophysiological evidence

Gooding

Burroughs

Boutros

2008

Psychiatry Research

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Although there are several reports of patients with cocaine dependence displaying cognitive deficits, the nature of their information processing deficits is not well characterized. In the present study, the attentional performance of cocaine-dependent patients (n = 14) was examined and compared with that of healthy control individuals (n = 15). Attention was assessed using an auditory oddball eventrelated task as well as the Continuous Performance Test (CPT; Identical Pairs version). The cocainedependent group displayed P300 amplitude reduction compared to controls. The group difference in P300 response latency did not reach significance. On the CPT, the cocaine-dependent patients displayed significantly poorer discriminability and greater errors of commission than the controls. There was a positive correlation between performance on the oddball event-related task and performance on the CPT. This investigation provides converging behavioral and electrophysiological evidence of attentional deficits in cocaine-dependent patients.

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Section: Discussionmentioning

confidence: 99%

Attentional deficits in cocaine-dependent patients: Converging behavioral and electrophysiological evidence

Gooding

Burroughs

Boutros

2008

Psychiatry Research

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“…About half of -referred and community samples of adults with BPD have a lifetime history of SUD (Himmelhoch, 1979, Merikangas, et al, 2007, Reich, et al, 1974, Strakowski, et al, 1998, Winokur, et al, 1995. Likewise, an excess of BPD has also been reported in SUD samples (Gawin and Kleber, 1986, Regier, et al, 1990, Rounsaville, et al, 1982, 1991, Weiss, et al, 1988. Data from studies of BPD adults also suggest that the risk for SUD is particularly high in those adults who had the onset of their BPD prior to age 18 years (Dunner and Feinman, 1995, Fleck, et al, 2006, Goldstein and Levitt, 2006, Lin, et al, 2006, Perlis, et al, 2004.…”

Section: Introductionmentioning

confidence: 90%

Further evidence of an association between adolescent bipolar disorder with smoking and substance use disorders: A controlled study

Wilens

Biederman

Adamson

et al. 2008

Drug and Alcohol Dependence

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“…Family, twin, and adoption studies indicate that genes play a significant etiologic role in the development of substance use disorders (SUDs) (Cloninger, 1987, Luthar and Rounsaville, 1993, Merikangas, et al, 1985, Mirin, et al, 1986, Pickens, et al, 1991, Rounsaville, et al, 1991, Tsuang, et al, 1998. Although these studies have led to the widely accepted conclusion that much of the familial transmission of SUDs is due to genes, the specific genes involved have been difficult to detect.…”

Section: Introductionmentioning

confidence: 99%

Familial transmission of derived phenotypes for molecular genetic studies of substance use disorders

Faraone

Adamson

Wilens

et al. 2008

Drug and Alcohol Dependence

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Although family, twin, and adoption studies indicate that genes play a significant etiologic role in the development of substance use disorders (SUDs), detecting specific genes has been difficult due to uncertainties about how to define SUDs, genetic heterogeneity and variable phenotypic expression of SUD genotypes. We used data from families recruited into six contemporaneous studies of children and adults to derive candidate SUD phenotypes using principle factors factor analysis with varimax rotation. We previously found evidence of two SUD phenotypes in offspring: a psychopathology dimension and a cognitive impairment dimension. We found evidence for one SUD-related phenotype in adults that we term Psychopathology and Cognitive Impairment. Parental factor scores significantly predicted both offspring phenotypes, as well as parental SUD (OR=1.41,p<0.001) and offspring SUD (mother's phenotype: OR=1.34,p=0.04; father's phenotype: OR=1.33,p=0.01). Offspring phenotype predicted offspring SUD (psychopathology phenotype: OR=2.96,p<0.001; cognitive impairment: OR=1.33,p=0.04); in offspring, baseline psychopathology predicted SUD at follow-up assessments (OR=1.55,p=0.01). Results suggest that these candidate SUD phenotypes may be useful for genetic studies of SUD.Correspondence: Dr. Stephen V. Faraone, Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, 750 East Adams St., Syracuse, NY 13210; faraones@upstate.edu, 315-464-3113, (315) 464-3255 (fax). Contributors Stephen V. Faraone participated in study design and execution, planned the analyses, and wrote portions of the manuscript Joel J. Adamson performed data analyses and wrote portions of the manuscript Timothy E. Wilens participated in study design and execution and provided clinical comments on the manuscript Michael C. Monuteaux assisted with the statistical analysis. Participated in study design and execution and provided clinical comments on the manuscript Joseph Biederman participated in study design and execution and provided clinical comments on the manuscript Conflict of Interest Dr. Stephen Faraone receives/d research support from, is/has been a speaker for, or is/has been on the advisory board for the following companies: Eli Lilly & Company, McNeil Consumer & Specialty Pharmaceuticals, Shire US Inc., Noven Pharmaceuticals, Cephalon, National Institute of Mental Health (NIMH), National Institute of Child Health and Human Development (NICHHD), and National Institute of Neurological Disorders and Stroke (NINDS). Dr. Timothy Wilens receives/d research support from, is/has been a speaker for, or is/has been on the advisory board for the following Pharmaceutical Companies: Abbott Laboratories, OrthoMcNeil, Eli Lilly and Company, Novartis Pharmaceuticals, Shire Laboratories Inc. and National Institute on Drug Abuse (NIDA). Dr. Joseph Biederman receives/d research support from, is/has been a speaker for, or is/has been on the advisory board for the following Pharmaceutical Companies: Shire, Eli Lilly, Pfizer, McNeil, Ab...

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Psychiatric Diagnoses of Treatment-Seeking Cocaine Abusers

Cited by 578 publications

References 43 publications

Attentional deficits in cocaine-dependent patients: Converging behavioral and electrophysiological evidence

Attentional deficits in cocaine-dependent patients: Converging behavioral and electrophysiological evidence

Further evidence of an association between adolescent bipolar disorder with smoking and substance use disorders: A controlled study

Familial transmission of derived phenotypes for molecular genetic studies of substance use disorders

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