Psychiatric comorbidity in epilepsy: A study comparing patients with mesial temporal sclerosis and juvenile myoclonic epilepsy

Filho, Gerardo Maria de Araújo; Rosa, Vivianne Pellegrino; Lin, Kátia; Caboclo, Luís Otávio Sales Ferreira; Sakamoto, Américo Ceiki; Yacubian, Elza Márcia Targas

doi:10.1016/j.yebeh.2008.01.008

Cited by 89 publications

(37 citation statements)

References 34 publications

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“…[38] Now, there exists a possible link between JME and mesial temporal lobe epilepsy. [39] Findings from temporal and also, occipital regions in our study point toward some not-yet-defined structural aberrations in these regions. EEG-fMRI has been used in the past to study epileptic networks (for review see Gotman (2008)).…”

Section: Discussionmentioning

confidence: 58%

Juvenile myoclonic epilepsy: Clinical characteristics, standard and quantitative electroencephalography analyses

et al. 2013

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Objectives:Most studies comparing inter-ictal background quantitative electroencephalography (EEG) measures in generalized epilepsies with normal controls do not specifically determine patients with juvenile myoclonic epilepsy (JME) as a separate group. The study aims at comparing absolute spectral power and global field coherence in various frequency bands between patients diagnosed exclusively with JME and 10 healthy controls, and correlating significantly different quantitative EEG measures with various clinical characteristics and standard EEG abnormalities.Materials and Methods:Clinical and EEG data were collected from 10 patients with JME and 10 healthy controls. Spectral power and global field spectral coherence were calculated using Welch's averaged periodogram method. The data was analyzed using descriptive statistics, Fisher's exact test and t-test.Results:Statistically significant (or trend level) higher power (global α and θ, frontal α and θ, left temporal θ, right occipital α, δ and γ1, and central δ, θ, α, β, and γ2) and coherence (global α and γ1) was found in JME patients when compared to controls. Significant correlation of left frontal and central θ-power with presence of absence seizures (negative), central δ-, and θ-power with the presence of psychiatric comorbidity and central θ-power with frequency of myoclonic seizures was found.Conclusion:Findings on global–frontal and temporal–occipital power support mild diffuse epileptogenic state and θ-activity as an endophenotype concepts in JME patients, respectively; findings suggest future studies on JME to include psychiatric comorbidity while selecting the sample; some spectral measures (e.g., central θ-power) do relate to progression of JME while some do not.

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Section: Discussionmentioning

confidence: 58%

Juvenile myoclonic epilepsy: Clinical characteristics, standard and quantitative electroencephalography analyses

et al. 2013

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“…However, most of this research has been limited to the investigation of selective samples, such as refractory mesial temporal sclerosis (MTS) and juvenile myclonic epilepsy (JME) [9,10], temporal lobe epilepsy (TLE) [11], and refractory focal epilepsy [12][13][14]. Collectively, these more recent studies have reported rates of mood disorders ranging from 25% to 48% and anxiety disorders from 14% to 31%.…”

Section: Introductionmentioning

confidence: 99%

Rates of DSM-IV mood, anxiety disorders, and suicidality in Australian adult epilepsy outpatients: A comparison of well-controlled versus refractory epilepsy

Gandy¹,

Sharpe²,

Perry³

et al. 2013

Epilepsy & Behavior

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“…5 Yet, our patient did not show clinical epileptic symptoms. 5 Yet, our patient did not show clinical epileptic symptoms.…”

Section: Discussionmentioning

confidence: 49%

Combined symptomatology of psychosis, pica syndrome, and hippocampal sclerosis: A case report

Rohde

Claussen

Kuechenhoff

et al. 2012

Intl J Eating Disorders

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Pica is the developmentally and culturally inappropriate eating of nonnutritive substances for at least 1 month. Herein, we present the case of a male patient that suddenly showed behavioral changes including aggressiveness, withdrawal, and perceptional disturbances at the age of 12. About 7 years later, pica symptoms emerged additionally. Neither pharmacotherapy nor electroconvulsive therapy led to success. Magnetic resonance imaging showed bilateral sclerosis of the hippocampus. The therapy with carbamazepine, clozapine, diazepam, and zinc finally improved the symptoms including the pica symptoms.

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Psychiatric comorbidity in epilepsy: A study comparing patients with mesial temporal sclerosis and juvenile myoclonic epilepsy

Cited by 89 publications

References 34 publications

Juvenile myoclonic epilepsy: Clinical characteristics, standard and quantitative electroencephalography analyses

Juvenile myoclonic epilepsy: Clinical characteristics, standard and quantitative electroencephalography analyses

Rates of DSM-IV mood, anxiety disorders, and suicidality in Australian adult epilepsy outpatients: A comparison of well-controlled versus refractory epilepsy

Combined symptomatology of psychosis, pica syndrome, and hippocampal sclerosis: A case report

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