Psychiatric comorbidity and social aspects in pregnant women with epilepsy — The Norwegian Mother and Child Cohort Study

Reiter, Simone Frizell; Veiby, Gyri; Daltveit, AK; Engelsen, Bernt A.; Gilhus, Nils Erik

doi:10.1016/j.yebeh.2013.08.016

Cited by 33 publications

(32 citation statements)

References 168 publications

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“…High seizure frequency and previous anxiety and/or depression were the strongest risk factors (23). Women with epilepsy had a higher life-time prevalence of eating disorders, and more often had binge eating disorder during pregnancy than women without epilepsy (21,22).…”

Section: Maternal Risk Factors For Adverse Offspring Outcomementioning

confidence: 98%

“…Using screening tools, 19.4% of the AED treated and 14.0% of the untreated women with epilepsy screened positive for early pregnancy depression and/or anxiety, compared to 10.8% in the reference population (p<0.01 and p=0.05 respectively). For the AED treated women the risk was still significant after adjustment for age, education, income, unemployment, and single parenting (21). The point prevalence of depression and 1) Subjects)with)dose)and/or)plasma)concentration)available.…”

Section: Maternal Risk Factors For Adverse Offspring Outcomementioning

confidence: 98%

“…We have investigated differences in the occurrence of low level of education (12 years or less), low income (199,999 NOK or less/yr, equal to 24 000 Euro), unemployment due to disability, single parenting, depression and/or anxiety from early pregnancy to 3 years after delivery, as well as eating disorders before and after pregnancy in in the MoBa cohort (21)(22)(23). Currently, we are investigating the impact of body weight increase during pregnancy on pregnancy complications in women with epilepsy, including overweight and obesity.…”

Section: Psychosocial Characteristics and Psychiatric Diseasementioning

confidence: 99%

See 2 more Smart Citations

Using the Norwegian Mother and Child Cohort Study to determine risk factors for delayed development and neuropsychiatric

Bjørk¹,

Veiby²,

Spigset³

et al. 2014

Nor J Epidemiol

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Introduction: Antiepileptic drug (AED) teratogenicity is suspected to be the main cause of impaired development in children of women with epilepsy. However, many factors may confound the reported risks. The purpose of this review is to characterize the epilepsy cohort in the Norwegian Mother and Child Cohort Study (MoBa) and show how it can be used to detangle various risk factors for adverse outcome in children of mothers with epilepsy. Methods: MoBa is a large, long-term prospective, family-based cohort study. The database is linked to the Medical Birth Registry of Norway. The epilepsy cohort consists of mothers and their children representing more than 700 pregnancies. Blood samples were obtained from the mother during pregnancy and from the umbilical cord after delivery, and AED concentrations were measured. Validated screening tools determined the frequency of maternal confounding risk factors and adverse offspring outcomes. Risk estimates were reported as adjusted odds ratios with confidence intervals using the remaining MoBa cohort as a reference (n=107,597). Outcome in offspring of women with epilepsy without AED treatment in pregnancy and of fathers with epilepsy were used to separate the effect of epilepsy from the effect of in utero exposure to AEDs. Results: Socioeconomic and psychiatric risk factors for adverse offspring outcomes were more frequent in mothers with epilepsy. The frequency of adverse offspring outcome was increased at 6, 18 and 36 months for verbal, motor and social development. Children of women with epilepsy without AED treatment and of fathers with epilepsy were generally similar to children of women without epilepsy. Conclusion: Children of mothers with epilepsy are at risk of adverse outcomes. AED exposure emerges as the most important risk factor.

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Section: Maternal Risk Factors For Adverse Offspring Outcomementioning

confidence: 98%

Section: Maternal Risk Factors For Adverse Offspring Outcomementioning

confidence: 98%

Section: Psychosocial Characteristics and Psychiatric Diseasementioning

confidence: 99%

See 1 more Smart Citation

Using the Norwegian Mother and Child Cohort Study to determine risk factors for delayed development and neuropsychiatric

Bjørk¹,

Veiby²,

Spigset³

et al. 2014

Nor J Epidemiol

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“…Depression has a particularly high prevalence rate in patients with epilepsy, and WWE are at increased risk of developing depression (Beghi et al, 2004). Moreover, symptoms of depression have been reported by WWE before and after pregnancy (Reiter et al, 2013). Postpartum depression rates are higher in WWE as compared to the general population and the choice of AED has not been found to modify the risk of developing postpartum depression (Galanti et al, 2009).…”

Section: Mental Healthmentioning

confidence: 99%

Women with epilepsy: clinically relevant issues

Bangar¹,

Shastri²,

El‐Sayeh³

et al. 2016

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SummaryWomen with epilepsy (WWE) face specific challenges throughout their lifespan due to the effects of seizures and antiepileptic drugs on hormonal function, potentially affecting both sexual and reproductive health. This review article addresses the most common issues of practical relevance to clinicians treating WWE: epidemiology and clinical presentations (including catamenial epilepsy), contraception, reproductive and sexual dysfunction, pregnancy, lactation, menopause-related issues (including bone health), and mental health aspects. Awareness of these gender-specific issues and implementation/adaptation of effective interventions for WWE results in significantly improved health-related quality of life in this patient population.

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“…In two Norwegian population-based studies of social aspects in pregnant WWE, women taking AEDs had a high frequency of low education, low income, and unemployment due to disability. Four percent were single mothers [23]. More than 20% reported previous sexual and/or physical abuse, and 1 in 4 stated that the pregnancy was unplanned [24].…”

Section: Background Factorsmentioning

confidence: 99%

Depression and anxiety during pregnancy and the postpartum period in women with epilepsy: A review of frequency, risks and recommendations for treatment

Bjørk

Veiby

Engelsen

et al. 2015

Seizure

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Peripartum depression is frequent in WWE and seldom medically treated. Health personnel should screen WWE for psychiatric disease and risk factors during pre-pregnancy planning, pregnancy and postpartum follow up. Treatment decisions should rely on efficacy and safety data in peripartum patients without epilepsy and non-pregnant people with epilepsy. Consequences of in utero exposure to AED therapy in combination with antidepressants are not known, and non-pharmacological treatment should be tried first.

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Psychiatric comorbidity and social aspects in pregnant women with epilepsy — The Norwegian Mother and Child Cohort Study

Cited by 33 publications

References 168 publications

Using the Norwegian Mother and Child Cohort Study to determine risk factors for delayed development and neuropsychiatric

Using the Norwegian Mother and Child Cohort Study to determine risk factors for delayed development and neuropsychiatric

Women with epilepsy: clinically relevant issues

Depression and anxiety during pregnancy and the postpartum period in women with epilepsy: A review of frequency, risks and recommendations for treatment

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