Psychiatric comorbidities in women with Celiac Disease

Abstract

Despite largely adhering to a gluten-free diet, a substantial subset of women with Celiac Disease report clinically relevant symptoms of depression and disordered eating; such symptoms are associated with increased psychosocial distress in other domains. These results suggest potential to improve the patient well-being through attention to psychosocial care, in addition to existing dietary recommendations for individuals with Celiac Disease.

The relationship between gluten free diet adherence and depressive symptoms in adults with coeliac disease: A systematic review with meta-analysis

“…When reported, the mean scores for GFD adherence indicated that, on average, participants were highly adherent (Arigo et al, 2012;Edwards-George et al, 2009;Mahadev et al, 2015;Sainsbury et al, 2013aSainsbury et al, , 2013b. The proportion of each sample falling into the inadequate adherence range (21.4-43.4%) suggested lower rates of strict adherence though Mahadev et al, 2015;Nachman et al, 2009;Nachman et al, 2010;Sainsbury et al, 2013aSainsbury et al, , 2013b).…”

“…Following title and abstract screening, 84 papers were retained for full-text screening, which resulted in 8 studies (reported in 9 papers) being included in the meta-analysis (Arigo, Anskis, & Smyth, 2012;Edwards-George et al, 2009;Kerswell & Strodl, 2015;Mahadev, Gardner, Lewis, Lebwohl, & Green, 2015;Nachman et al, 2009;Nachman et al, 2010;Sainsbury, Mullan, & Sharpe, 2013a, 2013bWeiss et al, 2013). All 8 studies measured depressive symptoms; no studies that measured clinically diagnosable depression and met other criteria were identified.…”

“…Studies were published between 2009 and 2015, and included between 53 and 390 CD patients (total N=1644; median=188). Four studies were conducted in the USA (Arigo et al, 2012;Edwards-George et al, 2009;Mahadev et al, 2015;Weiss et al, 2013), three in Australia (Kerswell & Strodl, 2015;Sainsbury et al, 2013aSainsbury et al, , 2013b, and one in Argentina (one study published in two papers; Nachman et al, 2009;Nachman et al, 2010). Females were over-represented in all samples (median=83.4% female; range=76.6-100%).…”

“…Seven studies used a cross-sectional design (Arigo et al, 2012;Edwards-George et al, 2009;Kerswell & Strodl, 2015;Mahadev et al, 2015;Sainsbury et al, 2013aSainsbury et al, , 2013bWeiss et al, 2013).…”

“…Five studies measured GFD adherence using the CDAT (Kerswell & Strodl, 2015;Mahadev et al, 2015;Sainsbury et al, 2013aSainsbury et al, , 2013bWeiss et al, 2013), two used a dietitian-rated assessment Nachman et al, 2009;Nachman et al, 2010), and one used the adapted Morisky adherence scale (Arigo et al, 2012). When reported, the mean scores for GFD adherence indicated that, on average, participants were highly adherent (Arigo et al, 2012;Edwards-George et al, 2009;Mahadev et al, 2015;Sainsbury et al, 2013aSainsbury et al, , 2013b.…”