Psychiatric comorbidities and photophobia in patients with migraine

Seidel, Stefan; Beisteiner, Roland; Manecke, Maike; Aslan, Tuna Stefan; Wöber, Christian

doi:10.1186/s10194-017-0718-1

Cited by 22 publications

(13 citation statements)

References 22 publications

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“…Moreover, there was a strong correlation between time in light and time in center ( Supplementary Figure 2A ), suggesting that light aversion is correlated to anxiety. This result is consistent with clinical studies that anxiety symptoms were positively correlated to light aversion in migraine patients with the possibility that anxiety contributes to light aversion ( 67 ).…”

Section: Discussionsupporting

confidence: 92%

CGRP Administration Into the Cerebellum Evokes Light Aversion, Tactile Hypersensitivity, and Nociceptive Squint in Mice

et al. 2022

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The neuropeptide calcitonin gene-related peptide (CGRP) is a major player in migraine pathophysiology. Previous preclinical studies demonstrated that intracerebroventricular administration of CGRP caused migraine-like behaviors in mice, but the sites of action in the brain remain unidentified. The cerebellum has the most CGRP binding sites in the central nervous system and is increasingly recognized as both a sensory and motor integration center. The objective of this study was to test whether the cerebellum, particularly the medial cerebellar nuclei (MN), might be a site of CGRP action. In this study, CGRP was directly injected into the right MN of C57BL/6J mice via a cannula. A battery of tests was done to assess preclinical behaviors that are surrogates of migraine-like symptoms. CGRP caused light aversion measured as decreased time in the light zone even with dim light. The mice also spent more time resting in the dark zone, but not the light, along with decreased rearing and transitions between zones. These behaviors were similar for both sexes. Moreover, significant responses to CGRP were seen in the open field assay, von Frey test, and automated squint assay, indicating anxiety, tactile hypersensitivity, and spontaneous pain, respectively. Interestingly, CGRP injection caused significant anxiety and spontaneous pain responses only in female mice, and a more robust tactile hypersensitivity in female mice. No detectable effect of CGRP on gait was observed in either sex. These results suggest that CGRP injection in the MN causes light aversion accompanied by increased anxiety, tactile hypersensitivity, and spontaneous pain. A caveat is that we cannot exclude contributions from other cerebellar regions in addition to the MN due to diffusion of the injected peptide. These results reveal the cerebellum as a new site of CGRP actions that may contribute to migraine-like hypersensitivity.

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Section: Discussionsupporting

confidence: 92%

CGRP Administration Into the Cerebellum Evokes Light Aversion, Tactile Hypersensitivity, and Nociceptive Squint in Mice

et al. 2022

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“…Thus, we conclude that the light aversion induced in males is not solely driven by anxiety, while in females the light aversion may be influenced by an overall increased anxiety level. Anxiety symptoms have been reported to be positively correlated to light aversion in migraine patients with the possibility that anxiety contributes to light aversion (103). In male mice, there appears to be a biphasic response where an anxiety-like response may have occurred during the final 10 min of the assay.…”

Section: The Mn and Light Aversionmentioning

confidence: 99%

CGRP Administration into the Cerebellum Evokes Migraine-like Behaviors Predominately in Female Mice

Duong

Rea

Waite

et al. 2022

Preprint

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The neuropeptide calcitonin gene-related peptide (CGRP) is a major player in migraine pathophysiology. Previous preclinical studies demonstrated that intracerebroventricular administration of CGRP caused migraine-like behaviors in mice, but the sites of action in the brain remain unidentified. The cerebellum has the most CGRP binding sites in the central nervous system and is increasingly recognized as both a sensory and motor integration center. The objective of this study was to test whether the cerebellum, particularly the medial cerebellar nuclei (MN), might be a site of CGRP action. In this study, CGRP was directly injected into the right MN of C57BL/6J mice via a cannula. A battery of behavioral tests was done to assess migraine-like behaviors. CGRP caused light aversion measured as decreased time in the light zone even with dim light. The mice also spent more time resting in the dark zone, but not the light, along with decreased rearing and transitions between zones. These behaviors were similar for both sexes. In contrast, significant responses to CGRP were seen only with female mice in the open field assay, von Frey test, and automated squint assay, indicating anxiety, tactile hypersensitivity, and spontaneous pain, respectively. In male mice, the responses had the same trend as females but did not reach statistical significance. No detectable effect of CGRP on gait was observed in either sex. These results suggest that CGRP in the MN causes light aversion in males, while in females, light aversion is accompanied by increased anxiety, tactile hypersensitivity, and spontaneous pain. A caveat is that we cannot exclude contributions from other cerebellar regions in addition to the MN due to diffusion of the injected peptide. These results reveal the cerebellum as a new site of CGRP actions that may contribute to migraine pathophysiology and possibly its prevalence in females.

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“…Ictal photophobia has also been positively correlated with age, and interictal photophobia with age and depression, anxiety and stress in patients with episodic migraine assessed by the Depression, Anxiety and Stress Scale. 27 Several questionnaires have been developed with the aim of detecting or assessing the intensity of photophobia. The 8-item Korean Photophobia Questionnaire (KUMC-8), focuses on symptoms during the attack, including photophobia behavioural responses, photic allodynia and photo-oculodynia, and also includes a question regarding interictal photophobia.…”

Section: Photophobia Burden and Assessmentmentioning

confidence: 99%

Dim the Lights: A Narrative Review of Photophobia in Migraine

Villar-Martínez¹,

Goadsby²

2022

Neurology

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A preference for darkness is one of the main associated features in people with migraine, the cause remaining a mystery until some decades ago. In this article, we describe the epidemiology of photophobia in migraine and explain the pathophysiological mechanisms following an anatomical structure. In addition, we review the current management of migraine and photophobia. Ongoing characterization of patients with photophobia and its different manifestations continues to increase our understanding of the intricate pathophysiology of migraine and vice versa. Detailed phenotyping of the patient with photophobia is encouraged.

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Psychiatric comorbidities and photophobia in patients with migraine

Cited by 22 publications

References 22 publications

CGRP Administration Into the Cerebellum Evokes Light Aversion, Tactile Hypersensitivity, and Nociceptive Squint in Mice

CGRP Administration Into the Cerebellum Evokes Light Aversion, Tactile Hypersensitivity, and Nociceptive Squint in Mice

CGRP Administration into the Cerebellum Evokes Migraine-like Behaviors Predominately in Female Mice

Dim the Lights: A Narrative Review of Photophobia in Migraine

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