Psychiatric comorbidities among patients undergoing liver transplantation in South Korea: a nationwide population-based study

Heo, Jaesung; Noh, O Kyu; Oh, Younjae; Chun, Mison; Kim, Logyoung

doi:10.1007/s12072-018-9849-y

Cited by 15 publications

(16 citation statements)

References 23 publications

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“…South Korea has a public medical insurance system based on fee-for-service, known as the National Health Insurance (NHI) system, covering approximately 98% of the country's population [10,11]. It is mandatory for all South Koreans to register with the NHI.…”

Section: Data Sourcementioning

confidence: 99%

Effects of Comorbid Alcohol Use Disorder on the Clinical Outcomes of Schizophrenia: A Nationwide Population-based Study

Ahn

Choi

et al. 2021

Preprint

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BackgroundAlcohol use disorder (AUD) is a common psychiatric comorbidity in schizophrenia, associated with poor clinical outcomes and medication noncompliance. Most previous studies on the effect of alcohol use in patients with schizophrenia had limitations of small sample size and a cross-sectional design. Therefore, this study aimed to use a nationwide population database to investigate the impact of AUD on clinical outcomes of schizophrenia.MethodsData from the Health Insurance Review Agency database in South Korea from January 1, 2007 to December 31, 2016 was used. Among 64,442 patients with incident schizophrenia, 1,598 with comorbid AUD were selected based on the diagnostic code F10. We performed between- and within-group analyses to compare the rates of psychiatric admissions and emergency room (ER) visits and medication possession ratio (MPR) with control patients having schizophrenia matched for the onset age, sex, and observation period.ResultsThe rates of psychiatric admissions and ER visits decreased after the diagnosis of AUD in both groups; however, the decrease was significantly greater in patients with comorbid AUD compared to the control group. While the case group showed an increase in MPR after the diagnosis of AUD, MPR decreased in the control patients. The rates of psychiatric admissions, ER visits and MPR were worse in the schizophrenia group with comorbid AUD both before and after the diagnosis of AUD.ConclusionsClinical outcomes were worse in the comorbid AUD group than in the control group before and after the diagnosis of AUD. Considering that patients with schizophrenia with comorbid AUD had poorer clinical outcomes even before the diagnosis of AUD, schizophrenia with comorbid AUD could be a distinct subtype of schizophrenia.

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Section: Data Sourcementioning

confidence: 99%

Effects of Comorbid Alcohol Use Disorder on the Clinical Outcomes of Schizophrenia: A Nationwide Population-based Study

Ahn

Choi

et al. 2021

Preprint

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“…Unlike studies of other cancers, prostate cancer survivors are all men of relatively older age. Previous studies regarding mental disorders among prostate cancer survivors have used a cross‐sectional design and small sample size .…”

Section: Introductionmentioning

confidence: 99%

Psychological distress among prostate cancer survivors in South Korea: A nationwide population‐based, longitudinal study

Heo

Noh

Chun

et al. 2019

Asia-Pac J Clncl Oncology

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Aim This time‐dependent study aimed to analyze the prevalence of psychological distress in prostate cancer survivors by using claims data in South Korea. Methods In a nationwide cohort, 32 005 patients were identified who were diagnosed with prostate cancer between January 2010 and December 2014. We referred the diagnostic codes of mental disorders as psychological distress. We categorized the prevalence of psychological distress based on age and specific times before and after the cancer diagnosis. Results The median age at diagnosis of prostate cancer was 70 years. Among 32 005 patients, 3074 (9.6%) were diagnosed at least once with a mental disorder between 1 year before the cancer diagnosis and the last follow‐up. Among the first diagnoses of each patient, the common mental disorders were anxiety (39.1%) and depression (33.0%). In the total cohort, there were 54 666 claims for mental disorders and over 48.0% (26 256) were for depression. The frequency of psychological distress peaked just before cancer diagnosis. Anxiety was frequent before diagnosis of prostate cancer, whereas depression was frequent after diagnosis. Although stress reaction/adjustment disorders were relatively high in the younger group, depression was relatively high in the elderly group. Conclusion Psychological distress in prostate cancer survivors showed different patterns of prevalence between before and after cancer diagnosis, as well as between age groups. Timely diagnosis and intervention for mental health could promote quality of life for prostate cancer survivors.

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“…Several studies support the need to establish reliable screening strategies: These should cover for the presence of psychiatric, behavioral, and psychosocial risk factors that may impair the outcome of the transplantation, the survival of the patient as well as of the organ, the adherence to the medical prescriptions, and may determine the onset of medical-psychiatric comorbidities after surgery [3,4,5].…”

Section: Introductionmentioning

confidence: 99%

“…Psychosocial risk factors are known to be particularly frequent and/or complex among candidates to liver transplantation, both before and after surgery [5]. Some of these patients suffer from HCV-related liver failure and often present with comorbid psychiatric disorders, frequently depression [6].…”

Section: Introductionmentioning

confidence: 99%

“…Some of these patients suffer from HCV-related liver failure and often present with comorbid psychiatric disorders, frequently depression [6]. Heo et al [5] argued that the prevalence of anxiety disorders is higher before transplantation, rather than after; furthermore, such disorders are frequently associated with hepatitis and cirrhosis. Lopez-Navas et al [7] identified depressive symptoms in the 47% of a sample made up of 70 patients waiting for liver transplantation.…”

Section: Introductionmentioning

confidence: 99%

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Stability of Psychiatric Diagnoses in Candidates to Liver Transplantation Referred to a Consultation-Liaison Psychiatry Service

Mattei

Moscara

Balducci

et al. 2019

JCM

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Objective: To investigate the stability over time of the psychiatric diagnoses among candidates to liver transplantation referred to a consultation-liaison psychiatric service. Method: Descriptive study, carried out at the Consultation-Liaison Psychiatry Service (CLPS) placed at the Modena (Italy) General University Hospital. All patients waiting for liver transplantation and repeatedly referred to the CLPS were enrolled. The observation period was from 1 January 2008 to 31 December 2013. Pearson’s coefficients were calculated to measure diagnostic stability (index referral vs. last referral). Results: One hundred patients were assessed (males 67%; mean age 53 ± 7 years old). The mean number of referrals for patients was 3 ± 2. The stability rate of psychiatric diagnosis was 64%. The following diagnoses or conditions were all significantly stable (i.e., all featured by r > 0.5 and p < 0.05): Adjustment disorder, depressive disorder, comorbid anxiety/depressive disorder, substance use disorder (including alcohol), absence of any disorder, and presence of any disorder. Conclusions: The good level of diagnostic stability displayed in the sample may be a function of the clinical and organizational “style” of the CLPS, namely the focus on identifying the prevailing personality traits, defensive mechanisms, and relational patterns.

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Psychiatric comorbidities among patients undergoing liver transplantation in South Korea: a nationwide population-based study

Abstract: Mental disorders in patients receiving LT showed different patterns of prevalence depending on age at the time of surgery and the nature of underlying diseases. Personalized intervention based on patient characteristics could improve the quality of life.

Cited by 15 publications

References 23 publications

Effects of Comorbid Alcohol Use Disorder on the Clinical Outcomes of Schizophrenia: A Nationwide Population-based Study

Effects of Comorbid Alcohol Use Disorder on the Clinical Outcomes of Schizophrenia: A Nationwide Population-based Study

Psychological distress among prostate cancer survivors in South Korea: A nationwide population‐based, longitudinal study

Stability of Psychiatric Diagnoses in Candidates to Liver Transplantation Referred to a Consultation-Liaison Psychiatry Service

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